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公开(公告)号：EP2167966A1
公开(公告)日：2010-03-31
申请号：EP08789293.1
申请日：2008-07-14
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745
摘要： The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).
摘要翻译： 本发明提供了用于确定样本流体（27）中目标部分（22）的存在和/或量的传感器装置（20）和方法，所述目标部分（22）用磁性或可磁化物体 ）。 传感器装置（20）包括适于在流体操纵期间施加用于将标记的靶部分（22,23）保持到传感器表面（24）的保持场的磁场产生装置。 由此，在这些流体操作期间，标记的靶部分（22,23）和传感器表面（24）和/或磁性粒子（23）和靶部分（22）之间的结合基本上不受干扰。 这导致可靠和精确的传感器装置（20）。
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公开(公告)号：EP1797388A1
公开(公告)日：2007-06-20
申请号：EP05784825.1
申请日：2005-07-21
发明人： NICOLE, Celine , LASANCE, Clemens, J., M. , PRINS, Menno, W., J. , BARET, Jean-Christophe , DECRE, Michel, M., J.
摘要： The present invention relates to a cooling system for an electronic substrate comprising a heat transfer fluid (4, 10). The heat transfer fluid (4, 10) is arranged to flow along a path (5, 11, 12) by capillary force.
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公开(公告)号：EP1685418A2
公开(公告)日：2006-08-02
申请号：EP04744650.5
申请日：2004-07-27
IPC分类号： G01R33/12
CPC分类号： G01R33/1269 , G01N15/0656 , G01N27/745 , G01N33/54326 , G01N35/0098 , G01N2035/00158 , G01R33/12
摘要： A device and method is disclosed for the detection or determination of the presence of magnetic particles (15), such as for example, but not limited to, magnetic tianoparticles. In particular it relates to an integrated or on-chip magnetic sensor element (11) for the detection of magnetic particles. The device and method of the present invention o er high signal-to-noise ratio and low power consumption and do not require an external magnetic field. They may be used for magnetic detection of binding of biological molecules on a micro-array or biochip.
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公开(公告)号：EP1518315A1
公开(公告)日：2005-03-30
申请号：EP03727907.2
申请日：2003-06-04
发明人： PRINS, Menno, W., J.
CPC分类号： G09B21/004 , G09B21/02 , H02N11/002 , H02N11/006
摘要： The invention refers to a tactile device provided with a number of fluid elements (1) containing an electrically conducting fluid (3, 4). The fluid level in each element is movable by actuator means (V, 6) applying a electric power to said fluid elements. Each fluid element is at one end provided with a tactile element (7) that is in contact with the fluid for perception of the fluid level by a user. The fluid elements comprise capillary tubes (2) in which the fluid level is movable as a result of electro-capillary pressure.
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公开(公告)号：EP1438865A1
公开(公告)日：2004-07-21
申请号：EP02765271.8
申请日：2002-09-18
发明人： FEENSTRA, Bokke, J. , PRINS, Menno, W., J. , VAN DE WALLE, Gerjan, F., A. , VAN TONGEREN, Henricus, F., J., J.
CPC分类号： G02B26/005 , G02B27/2214 , H04N13/305 , H04N13/359
摘要： Switching between 2D and 3D visualization is achieved by an optical-index matching fluid ( 9 ) which can be brought between a lenticular sheet ( 6, 7 ) and a top plate ( 10 ). The fluid may contain two immiscible fluids while switching is based on (re)distribution of the fluids due to electrostatic forces.
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公开(公告)号：EP1402314A1
公开(公告)日：2004-03-31
申请号：EP02735721.9
申请日：2002-06-04
CPC分类号： G02B26/005 , G02B26/0816 , G02F1/167 , G02F1/195 , G09F9/372
摘要： Display cells (10) contain two immiscible fluids (3, 4) having different refractive index or absorption coefficient, the cells being placed below a transparent substrate (10) having a prismatic structure enabling total internal reflection (TIR). Switching is based on frustrated TIR by (re)distribution of the fluids within the cell due to electrostatic forces on (external) electrodes (5, 6) and a potential applied to one of the fluids (4) which is electrically conducting.
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公开(公告)号：EP1042754B1
公开(公告)日：2003-06-11
申请号：EP99938389.6
申请日：1999-07-27
发明人： PRINS, Menno, W., J.
IPC分类号： G21K1/10
CPC分类号： G21K1/10
摘要： The invention relates to an X-ray examination apparatus which includes an X-ray filter for locally attenuating the X-ray beam. The X-ray filter includes a plurality of filter elements. The X-ray absorption of a filter element is adjusted by way of the quantity of X-ray absorbing liquid present in the filter element. The filling of the filter element is adjusted by means of an electric voltage. In addition to the X-ray absorbing liquid, the filter element contains a second liquid which is present at an interface between the X-ray absorbing liquid and the filter element, said second liquid being chemically inert relative to the X-ray absorbing liquid and having an electrical conductivity which deviates from that of the first liquid.
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8.发明公开X-RAY APPARATUS PROVIDED WITH A FILTER WITH A DYNAMICALLY ADJUSTABLE ABSORPTION 审中-公开与动态可调吸收能力的过滤器的X射线装置
公开(公告)号：EP1277214A1
公开(公告)日：2003-01-22
申请号：EP01927866.2
申请日：2001-04-04
发明人： PRINS, Menno, W., J.
IPC分类号： G21K1/10
CPC分类号： G21K1/10
摘要： An X-ray apparatus is equipped with an X-ray filter having adjustable absorption properties in order to reduce the dynamic range of an X-ray image. The filter includes a matrix of filter elements (13, 13', 13') in which a level of an X-ray absorption liquid can be varied. The amount of the X-ray absorption liquid within an individual filter element determines the value of the X-ray absorption within this filter element. It is necessary that the resultant amount of the X-ray absorption liquid within each filter element is reproducible. Such an X-ray filter (12) is mounted near the X-ray source and is rotated together with the gantry when an X-ray image is required with some angulation with respect to an object. When the X-ray filter is angled (ß) with respect to the vertical direction (g), the hydrostatic pressure within filter elements varies with respect to the calibrated state and the resultant amount of the X-ray absorption liquid is not reproducible. In order to compensate the variation of the hydrostatic pressure within the filter, the latter is provided with a hydrostatic pressure control system (131, 160).
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公开(公告)号：EP1068622A1
公开(公告)日：2001-01-17
申请号：EP00904954.5
申请日：2000-01-24
IPC分类号： G21K1/10
CPC分类号： G21K1/10
摘要： An X-ray filter comprises an array of filter elements (5) and a control circuit, the control circuit comprising an array of switching devices (33) provided on a common substrate (52), a switching device (33) being provided for each filter element for switching a control signal to the respective filter element. An output terminal of each switching device is provided with an external connection portion (54) located at the respective switching device. An array of external connection portions (54) is thus provided over the array of switching devices (33). The connection portions are then bonded to a connection block of the array of filter elements. This avoids the need to use edge connections of the substrate (52), and provides a secure mechanical and electrical connection between the control circuit and the filter array.
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公开(公告)号：EP2334433A1
公开(公告)日：2011-06-22
申请号：EP09787341.8
申请日：2009-10-01
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/086
摘要： A microfluidic device is provided, the microfluidic device comprising: a plurality of chambers (3, 4, 5, 6) adapted for performing chemical, biochemical, or physical processes and a flow path (9) connecting the plurality of chambers (3, 4, 5, 6) adapted for accommodating at least one magnetic particle (7) subsequently moving through the plurality of chambers The plurality of chambers (3, 4, 5, 6) are separated by at least one valve-like structure (10) adapted to enable passing-through of the at least one magnetic particle (7) from one of the plurality of chambers to another one of the plurality of chambers. At least one delaying structure (11, 111) adapted to delay movement of the at least one magnetic particle (7) along the flow path is provided.
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