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公开(公告)号：EP1127071A1
公开(公告)日：2001-08-29
申请号：EP99955835.6
申请日：1999-11-03
申请人： Novo Nordisk A/S
CPC分类号： C07K5/0207 , A61K38/00
摘要： This invention relates to novel compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
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公开(公告)号：EP1047709A1
公开(公告)日：2000-11-02
申请号：EP99900877.4
申请日：1999-01-15
申请人： NOVO NORDISK A/S
发明人： ANKERSEN, Michael
CPC分类号： C07K5/0207 , C07K5/06026 , C07K5/06078 , C07K5/0806
摘要： Compounds of general formula (I), and their use for treating medical disorders resulting from a deficiency in growth hormone.
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公开(公告)号：EP0869974A1
公开(公告)日：1998-10-14
申请号：EP96941591.0
申请日：1996-12-16
申请人： NOVO NORDISK A/S
发明人： HANSEN, Thomas, Kruse , PESCHKE, Bernd , LAU, Jesper , LUNDT, Behrend, Friedrich , ANKERSEN, Michael , WATSON, Brett , MADSEN, Kjeld
IPC分类号： C07D333 , A61K31 , A61K38 , A61P3 , A61P5 , A61P15 , A61P19 , B41J19 , C07C237 , C07C311 , C07C335 , C07D213 , C07D227 , C07D271 , C07D409 , C07D413 , C07K5 , C07K7 , C07K14
CPC分类号： C07D271/06 , A61K38/00 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Compounds of peptide mimetic nature having general formula (I), wherein a and b are independently 1 or 2, R?1 and R2¿ are independently H or C¿1-6?alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups, are growth hormone secretagogous with improved bioavailability.
摘要翻译： 具有通式（I）的肽模拟性质的化合物，其中a和b独立地为1或2，R 1和R 2独立地为H或C 1-6烷基，G和J独立地为芳族化合物 ，D和E独立地是几个不同的组，是生长激素促分泌素，具有改善的生物利用度。
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公开(公告)号：EP0869974B1
公开(公告)日：2009-03-04
申请号：EP96941591.8
申请日：1996-12-16
申请人： NOVO NORDISK A/S
发明人： HANSEN, Thomas, Kruse , PESCHKE, Bernd , LAU, Jesper , LUNDT, Behrend, Friedrich , ANKERSEN, Michael , WATSON, Brett , MADSEN, Kjeld
CPC分类号： C07D271/06 , A61K38/00 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Compounds of peptide mimetic nature having general formula (I), wherein a and b are independently 1 or 2, R?1 and R2¿ are independently H or C¿1-6?alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups, are growth hormone secretagogous with improved bioavailability.
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公开(公告)号：EP1531815A1
公开(公告)日：2005-05-25
申请号：EP03761446.8
申请日：2003-06-27
申请人： NOVO NORDISK A/S
发明人： POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LOPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSOE, Per , MURRAY, Anthony , JEPPESEN, Lone , LAU, Jesper
IPC分类号： A61K31/433 , A61P3/10 , A61P3/06 , A61P3/04 , C07D277/48 , C07D277/52 , C07D213/75 , C07D417/12 , C07D277/56 , C07D417/06 , C07D417/14 , C07D285/16 , C07D487/04 , C07D277/54
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives of the general formula (I), which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.(Formul 1).
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公开(公告)号：EP1230236B1
公开(公告)日：2004-10-20
申请号：EP00974349.3
申请日：2000-11-10
申请人： NOVO NORDISK A/S
发明人： ANKERSEN, Michael
IPC分类号： C07D401/06 , A61K31/445 , A61P5/00
CPC分类号： C07D401/06 , A61K31/454
摘要： The present invention relates to a novel diastereomeric compound, pharmaceutically acceptable salts thereof, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone, (Fig. 1).
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公开(公告)号：EP0923539B1
公开(公告)日：2002-06-05
申请号：EP97930368.2
申请日：1997-07-17
申请人： NOVO NORDISK A/S
IPC分类号： C07C237/16 , C07C237/20 , C07C281/06 , C07C311/08 , C07C311/21 , C07D207/08 , C07D217/06 , C07D241/08 , C07D333/20 , A61K31/16 , A61K31/33
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
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公开(公告)号：EP1077941A1
公开(公告)日：2001-02-28
申请号：EP99919125.7
申请日：1999-05-10
申请人： Novo Nordisk A/S
IPC分类号： C07D211/62 , C07D401/06 , A61K31/445
CPC分类号： C07D401/06 , C07D211/62
摘要： The present invention relates to novel compounds, in particular 4,4-disubstituted and 3,3-disubstituted piperidine compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
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公开(公告)号：EP0937065A1
公开(公告)日：1999-08-25
申请号：EP97910268.0
申请日：1997-10-29
申请人： NOVO NORDISK A/S
发明人： ANKERSEN, Michael , DÖRWALD, Florenzio, Zaragoza , STIDSEN, Carsten, Enggaard , CRIDER, Albert, Michael
IPC分类号： A61K31 , A61P1 , A61P3 , A61P9 , A61P11 , A61P25 , A61P27 , A61P43 , C07D213 , C07D295 , C07D401
CPC分类号： C07D213/74 , C07D401/12 , C07D401/14 , Y10S514/866
摘要： The present invention relates to a compound of general formula (I) for treating medical disorders related to binding to human somatostatin receptor subtypes.
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公开(公告)号：EP0923539A1
公开(公告)日：1999-06-23
申请号：EP97930368.0
申请日：1997-07-17
申请人： NOVO NORDISK A/S
IPC分类号： A61K31 , A61P5 , C07C237 , C07C243 , C07C281 , C07C311 , C07D207 , C07D211 , C07D217 , C07D241 , C07D333
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要： The present invention relates to novel compounds of general formula (I), pharmaceutical compositions containing them, a method of stimulating the release of growth hormone from the pituitary, a method for increasing the rate and extent of growth of animals to increase their milk and wool production, or for the treatment of ailments, and to use of the compounds for the preparation of medicaments.
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