公开(公告)号：EP1531815B1

公开(公告)日：2014-09-24

申请号：EP03761446.8

申请日：2003-06-27

申请人： NOVO NORDISK A/S ,  TransTech Pharma, LLC

发明人： POLISETTI, Dharma, Rao ,  KODRA, János, Tibor ,  LAU, Jesper ,  BLOCH, Paw ,  VALCARCE-LOPEZ,Maria,Carmen, ,  BLUME, Niels ,  GUZEL, Mustafa ,  SANTHOSH, Kalpathy, Chidambareswaran ,  MJALLI, Adnan, M., M. ,  ANDREWS, Robert, Carl ,  SUBRAMANIAN, Govindan ,  ANKERSEN, Michael ,  VEDSOE, Per ,  MURRAY, Anthony ,  JEPPESEN, Lone ,  LAU, Jesper

IPC分类号： A61K31/433 ,  A61P3/10 ,  A61P3/06 ,  A61P3/04 ,  C07D277/48 ,  C07D277/52 ,  C07D213/75 ,  C07D417/12 ,  C07D277/56 ,  C07D417/06 ,  C07D417/14 ,  C07D285/16 ,  C07D487/04 ,  C07D277/54

CPC分类号： C07D277/38 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61K45/06 ,  C07D213/75 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

公开(公告)号：EP1458382A1

公开(公告)日：2004-09-22

申请号：EP02787463.5

申请日：2002-12-19

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper ,  KODRA, János, Tibor ,  GUZEL, Mustafa ,  SANTOSH, Kalpathy, Chidambareswaran ,  MJALLI, Adnan, M., M. ,  ANDREWS, Robert, Carl ,  POLISETTI, Dharma, Rao

IPC分类号： A61K31/426 ,  A61K31/4402 ,  A61K31/505 ,  A61P3/04 ,  A61P3/10 ,  C07D277/46 ,  C07D417/12 ,  C07D213/75 ,  C07D409/12 ,  C07D239/42 ,  C07D405/12

CPC分类号： C07D277/46 ,  A61K31/16 ,  A61K31/18 ,  A61K45/06 ,  C07D213/75

摘要： This invention relates to compounds of the general formula (I) which are activators of glucokinase (GK), and which may be useful for the management, treatment, control, or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, for example diseases such as IGT, Syndrome X, type 2 diabetes, type 1 diabetes, dyslipidemia, hyperlipidemia, hypertension, and obesity.

公开(公告)号：EP1531815A1

公开(公告)日：2005-05-25

申请号：EP03761446.8

申请日：2003-06-27

申请人： NOVO NORDISK A/S

发明人： POLISETTI, Dharma, Rao ,  KODRA, János, Tibor ,  LAU, Jesper ,  BLOCH, Paw ,  VALCARCE-LOPEZ,Maria,Carmen, ,  BLUME, Niels ,  GUZEL, Mustafa ,  SANTHOSH, Kalpathy, Chidambareswaran ,  MJALLI, Adnan, M., M. ,  ANDREWS, Robert, Carl ,  SUBRAMANIAN, Govindan ,  ANKERSEN, Michael ,  VEDSOE, Per ,  MURRAY, Anthony ,  JEPPESEN, Lone ,  LAU, Jesper

IPC分类号： A61K31/433 ,  A61P3/10 ,  A61P3/06 ,  A61P3/04 ,  C07D277/48 ,  C07D277/52 ,  C07D213/75 ,  C07D417/12 ,  C07D277/56 ,  C07D417/06 ,  C07D417/14 ,  C07D285/16 ,  C07D487/04 ,  C07D277/54

CPC分类号： C07D277/38 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61K45/06 ,  C07D213/75 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

摘要： This invention relates to aryl carbonyl derivatives of the general formula (I), which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.(Formul 1).