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公开(公告)号：EP1723128A1
公开(公告)日：2006-11-22
申请号：EP05700554.8
申请日：2005-01-06
申请人： NOVO NORDISK A/S
发明人： MURRAY, Anthony , LAU, Jesper , JEPPESEN, Lone , VEDSO , Per , ANKERSEN, Michael , LUNDBECK, Jane, Marie , KRISTIANSEN, Marit , VALCARCE-LOPEZ, Maria Carmen , POLISETTI, Dharma, Rao , SUBRAMANIAN, Govindan , ANDREWS, Robert, Carl , CHRISTEN, Daniel, P. , COOPER, Jeremy, T. , SANTHOSH, Kalpathy, Chidambareswaran
IPC分类号： C07D277/48 , C07D277/56 , C07D285/12 , C07D277/82 , C07D241/20 , C07D285/08 , C07D277/60 , C07D213/75 , C07D233/88 , C07D271/08 , C07D261/14 , C07D417/12 , C07D417/04 , C07D417/06 , C07D417/14
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R1 and R2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial .
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公开(公告)号：EP1531815A1
公开(公告)日：2005-05-25
申请号：EP03761446.8
申请日：2003-06-27
申请人： NOVO NORDISK A/S
发明人： POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LOPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSOE, Per , MURRAY, Anthony , JEPPESEN, Lone , LAU, Jesper
IPC分类号： A61K31/433 , A61P3/10 , A61P3/06 , A61P3/04 , C07D277/48 , C07D277/52 , C07D213/75 , C07D417/12 , C07D277/56 , C07D417/06 , C07D417/14 , C07D285/16 , C07D487/04 , C07D277/54
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives of the general formula (I), which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.(Formul 1).
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公开(公告)号：EP1458382A1
公开(公告)日：2004-09-22
申请号：EP02787463.5
申请日：2002-12-19
申请人： NOVO NORDISK A/S
发明人： LAU, Jesper , KODRA, János, Tibor , GUZEL, Mustafa , SANTOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , POLISETTI, Dharma, Rao
IPC分类号： A61K31/426 , A61K31/4402 , A61K31/505 , A61P3/04 , A61P3/10 , C07D277/46 , C07D417/12 , C07D213/75 , C07D409/12 , C07D239/42 , C07D405/12
CPC分类号： C07D277/46 , A61K31/16 , A61K31/18 , A61K45/06 , C07D213/75
摘要： This invention relates to compounds of the general formula (I) which are activators of glucokinase (GK), and which may be useful for the management, treatment, control, or adjunct treatment of diseases or conditions, where increasing glucokinase activity is beneficial, for example diseases such as IGT, Syndrome X, type 2 diabetes, type 1 diabetes, dyslipidemia, hyperlipidemia, hypertension, and obesity.
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公开(公告)号：EP1531815B1
公开(公告)日：2014-09-24
申请号：EP03761446.8
申请日：2003-06-27
发明人： POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LOPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSOE, Per , MURRAY, Anthony , JEPPESEN, Lone , LAU, Jesper
IPC分类号： A61K31/433 , A61P3/10 , A61P3/06 , A61P3/04 , C07D277/48 , C07D277/52 , C07D213/75 , C07D417/12 , C07D277/56 , C07D417/06 , C07D417/14 , C07D285/16 , C07D487/04 , C07D277/54
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
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公开(公告)号：EP1723128B1
公开(公告)日：2012-11-07
申请号：EP05700554.8
申请日：2005-01-06
发明人： MURRAY, Anthony , LAU, Jesper , JEPPESEN, Lone , VEDSO , Per , ANKERSEN, Michael , LUNDBECK, Jane, Marie , KRISTIANSEN, Marit , VALCARCE-LOPEZ, Maria Carmen , POLISETTI, Dharma, Rao , SUBRAMANIAN, Govindan , ANDREWS, Robert, Carl , CHRISTEN, Daniel, P. , COOPER, Jeremy, T. , SANTHOSH, Kalpathy, Chidambareswaran
IPC分类号： C07D277/48 , C07D417/12 , A61K31/14 , A61K31/426 , A61P3/10
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
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