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32 条记录 (耗时 0.055 秒)

    ADAM8 AS TUMOR MARKER AND THERAPEUTIC TARGET FOR NON-SMALL CELL LUNG CANCER
    23.
    发明公开
    ADAM8 AS TUMOR MARKER AND THERAPEUTIC TARGET FOR NON-SMALL CELL LUNG CANCER 审中-公开
    ADAM8肿瘤标记，非小细胞肺癌的治疗靶标

    公开(公告)号：EP1730533A1

    公开(公告)日：2006-12-13

    申请号：EP04723042.0

    申请日：2004-03-24

    申请人： Oncotherapy Science, Inc.

    发明人： NAKAMURA, Yusuke ,  DAIGO, Yataro ,  NAKATSURU, Shuichi

    IPC分类号： G01N33/574 ,  C12N15/11 ,  C12N9/64

    CPC分类号： G01N33/57423 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： In searching for molecules involved in pulmonary carcinogenesis and genes that may serve as diagnostic markers or targets for new molecular therapies, the ADAM8 gene was discovered to be abundantly overexpressed in the great majority of NSCLC samples examined. Subsequent analysis proved that the serum levels of the ADAM8 protein detected by ELISA in lung-cancer patients were significantly higher than those in normal individuals. Furthermore, treatment of NSCLC cells with vector-based small interfering RNAs (siRNAs) against the ADAM8 gene suppressed its expression and resulted in growth suppression of the NSCLC cells. These results indicate that ADAM8 may be useful as a diagnostic marker and as a target for development of new molecular therapies for lung cancer.

    ECT2 AS A THERAPEUTIC TARGET FOR ESOPHAGEAL CANCER
    26.
    发明授权
    ECT2 AS A THERAPEUTIC TARGET FOR ESOPHAGEAL CANCER 有权
    ECT2 AS治疗靶点治疗食管癌

    公开(公告)号：EP1907582B1

    公开(公告)日：2012-01-04

    申请号：EP06782211.4

    申请日：2006-07-26

    申请人： Oncotherapy Science, Inc.

    发明人： NAKAMURA, Yusuke ,  DAIGO, Yataro ,  NAKATSURU, Shuichi

    IPC分类号： C12N15/113 ,  A61K48/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y10T436/25

    摘要： In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray representing 32,256 genes was constructed to analyze the expression profiles of 19 esophageal squamous-cell carcinomas (ESCCS) purified by laser-capture microdissection. A detailed genome-wide database for sets of genes that are significantly up- or down-regulated in esophageal cancer is disclosed herein. These genes find use in the development of therapeutic drugs or immunotherapy as well as tumor markers. Additionally, genes associated with lymph-node metastasis and post-surgery recurrence are disclosed herein. Among the candidate molecular target genes, a Homo sapiens epithelial cell transforming sequence 2 oncogene (ECT2) and a cell division cycle 45, S. cerevisiae, homolog-like (CDC45L) are further characterized. Treatment of ESCC cells with small interfering RNAs (siRNAs) of ECT2 or CDC45L suppressed growth of the cancer cells. Thus, the data herein provide valuable information for identifying diagnostic systems and therapeutic target molecules for esophageal cancer. Furthermore, the present inventors have identified DKK1 as a potential biomarker for diagnosis of cancer such as lung and esophageal cancers as well as prediction of the poor prognosis of the patients with these diseases. DKK1 was specifically over-expressed in most lung and esophageal cancer tissues the present inventors examined, and was elevated in the sera of a large proportion of patients with these tumors. DKK1, combined with other tumor markers, could significantly improve the sensitivity of cancer diagnosis. Moreover, this molecule is also a likely candidate for development of therapeutic approaches such as antibody therapy.

    METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCER
    30.
    发明授权
    METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCER 有权
    非小细胞肺癌的诊断方法

    公开(公告)号：EP1737979B1

    公开(公告)日：2011-01-19

    申请号：EP05721540.2

    申请日：2005-03-18

    申请人： Oncotherapy Science, Inc.

    发明人： NAKAMURA, Yusuke ,  DAIGO, Yataro ,  NAKATSURU, Shuichi

    IPC分类号： C12Q1/68

    CPC分类号： A61K31/731 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： Disclosed are methods for detecting non-small cell lung cancer (NSCLC) using differentially expressed genes KIF11, GHSR1b, NTSR1, and FOXM1. Also disclosed are methods of identifying compounds for treating and preventing NSCLC, based on the interaction between KOC1 and KIF11, or NMU and GHSR1b or NTSR1.

    摘要翻译： 公开了使用差异表达基因KIF11，GHSR1b，NTSR1和FOXM1检测非小细胞肺癌（NSCLC）的方法。 还公开了基于KOC1和KIF11或NMU和GHSR1b或NTSR1之间的相互作用鉴定用于治疗和预防NSCLC的化合物的方法。