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公开(公告)号：EP2970275B1
公开(公告)日：2018-05-09
申请号：EP14729498.7
申请日：2014-03-13
发明人： SINGH, Rajinder , DUNCTON, Matthew , ZHANG, Jing , ALVAREZ, Salvador , TSO, Kin , HOLLAND, Sacha , YEN, Rose , KOLLURI, Rao , HECKRODT, Thilo , CHEN, Yan , MASUDA, Esteban , LI, Hui , PAYAN, Donald G.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/506 , C07D471/04 , C07D498/04 , Y02A50/411
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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22.发明授权N3-HETEROARYL SUBSTITUTED TRIAZOLES AND N5-HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权N3-杂芳基取代的三唑和N5-杂芳基取代的三唑作为AXL抑制剂
公开(公告)号：EP2074115B1
公开(公告)日：2018-03-07
申请号：EP07866122.0
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D495/04 , C07D519/00 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D401/14 , C07D403/14
CPC分类号： C07D495/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： N 3 -Heteroaryl substituted triazoles and N 5 -heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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公开(公告)号：EP2970275A1
公开(公告)日：2016-01-20
申请号：EP14729498.7
申请日：2014-03-13
发明人： SINGH, Rajinder , DUNCTON, Matthew , ZHANG, Jing , ALVAREZ, Salvador , TSO, Kin , HOLLAND, Sacha , YEN, Rose , KOLLURI, Rao , HECKRODT, Thilo , CHEN, Yan , MASUDA, Esteban , LI, Hui , PAYAN, Donald G.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/506 , C07D471/04 , C07D498/04 , Y02A50/411
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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24.发明授权BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权BY桥双环芳基或 桥双环杂取代的三唑本身AS AXL抑制剂适合...
公开(公告)号：EP2114955B1
公开(公告)日：2013-02-13
申请号：EP07866125.3
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , DING, Pingyu , YU, Jiaxin , LITVAK, Joane
IPC分类号： C07D495/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D491/04 , C07D471/18 , C07D401/12 , C07D403/12 , C07D409/14
CPC分类号： C07D495/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/14 , C07D453/06 , C07D471/18
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25.发明公开POLYCYCLIC ARYL SUBSTITUTED TRIAZOLES AND POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权BY取代的三唑和多环杂芳基取代三唑本身AS AXL抑制剂SUITABLE环芳基
公开(公告)号：EP2205592A1
公开(公告)日：2010-07-14
申请号：EP07870108.3
申请日：2007-12-29
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D403/04 , C07D403/14 , C07D471/18 , C07D491/14 , A61K31/4196 , A61P19/00 , A61P35/00
CPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4375 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/08 , C07D471/18 , C07D491/14
摘要： Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
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26.发明公开
公开(公告)号：EP2078010A2
公开(公告)日：2009-07-15
申请号：EP07870107.5
申请日：2007-12-29
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D403/04 , C07D403/14 , C07D471/18 , C07D491/14 , A61K31/4196 , A61P19/00 , A61P35/00 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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公开(公告)号：EP1922310A2
公开(公告)日：2008-05-21
申请号：EP06814315.5
申请日：2006-09-07
发明人： SINGH, Rajinder , SYLVAIN, Catherine , HOLLAND, Sacha , ZHANG, Jing , PARTRIDGE, John J. , CLOUGH, Jeffrey , ARGADE, Ankush
IPC分类号： C07D249/14 , A61K31/4196 , A61P35/00
CPC分类号： C07D403/12 , C07D249/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Triazole derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase AxI. Methods of using tfrs* derivatives in treating diseases or conditions associated with AxI catalytic activity are also disclosed.
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