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公开(公告)号：EP2833889B1
公开(公告)日：2017-11-01
申请号：EP13773141.0
申请日：2013-04-04
发明人： SINGH, Rajinder , DUNCTON, Matthew , ZHANG, Jing , ALVAREZ, Salvador , TSO, Kin , HOLLAND, Sacha , YEN, Rose , KOLLURI, Rao , HECKRODT, Thilo , CHEN, Yan , MASUDA, Esteban , LI, Hui , PAYAN, Donald G. , KELLEY, Ryan
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61P29/00
CPC分类号： C07D471/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5386 , A61K31/553 , C07D519/00 , C12N9/12 , C12Q1/485 , C12Y207/11013
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：EP2079736B1
公开(公告)日：2017-10-18
申请号：EP07866124.6
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SYLVAIN, Catherine , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu
IPC分类号： C07D471/04 , C07D495/04 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D491/04
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/4355 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
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3.发明授权SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) 有权KLEINMOLEKÜL-HEMMER DER SPLEEN-TYROSINKINASE
公开(公告)号：EP2443123B1
公开(公告)日：2017-04-05
申请号：EP10790003.7
申请日：2010-06-14
发明人： ZHANG, Jing , SINGH, Rajinder , GOFF, Dane , KINOSHITA, Taisei
IPC分类号： C07D487/04 , C07D405/04 , A61K31/4162 , A61P37/02
CPC分类号： C07D487/04 , C07D405/04
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公开(公告)号：EP2833889A1
公开(公告)日：2015-02-11
申请号：EP13773141.0
申请日：2013-04-04
发明人： SINGH, Rajinder , DUNCTON, Matthew , ZHANG, Jing , ALVAREZ, Salvador , TSO, Kin , HOLLAND, Sacha , YEN, Rose , KOLLURI, Rao , HECKRODT, Thilo , CHEN, Yan , MASUDA, Esteban , LI, Hui , PAYAN, Donald G. , KELLEY, Ryan
IPC分类号： A61K31/535 , A61K31/445 , A61K31/505 , A01N43/40
CPC分类号： C07D471/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5386 , A61K31/553 , C07D519/00 , C12N9/12 , C12Q1/485 , C12Y207/11013
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及用作蛋白激酶C（PKC）抑制剂的化合物，因此可用于治疗通过PKC活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法以及用于这些方法的中间体。
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5.发明公开BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权AS AXL抑制剂SUITABLE桥接双环杂芳基取代的三唑
公开(公告)号：EP2328888A1
公开(公告)日：2011-06-08
申请号：EP09790063.3
申请日：2009-07-02
发明人： SINGH, Rajinder , HOLLAND, Sacha , LITVAK, Joane , GOFF, Dane , ZHANG, Jing , HECKRODT, Thilo, J.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D471/18 , A61K31/4196 , A61P35/00
CPC分类号： C07D403/04 , A61K31/502 , C07D221/22 , C07D237/26 , C07D237/34 , C07D401/14 , C07D403/14 , C07D471/18
摘要： Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase AxI. Methods of using the compounds in treating diseases or conditions associated with AxI activity are also disclosed.
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6.发明公开BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权BY双环芳基或 双环杂取代的三唑本身AS AXL INIHIBITOREN适合...
公开(公告)号：EP2114954A1
公开(公告)日：2009-11-11
申请号：EP07866121.2
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , HECKRODT, Thilo , DING, Pingyu , YU, Jiaxin , LITVAK, Joane
IPC分类号： C07D495/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： A61K31/519 , A61K31/395 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/14 , C07D495/04
摘要： Bicyclic aryl substituted triazoles or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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公开(公告)号：EP2079736A1
公开(公告)日：2009-07-22
申请号：EP07866124.6
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SYLVAIN, Catherine , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu
IPC分类号： C07D471/04 , C07D495/04 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D491/04
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/4355 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了含有这些化合物的取代的三唑和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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公开(公告)号：EP2595982B1
公开(公告)日：2018-06-13
申请号：EP11741505.9
申请日：2011-07-21
发明人： HOLLAND, Sacha , KOLLURI, Rao , ALVAREZ, Salvador , DUNCTON, Matthew , SINGH, Rajinder , ZHANG, Jing , MASUDA, Esteban
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , C12N9/12 , C12Y207/11013
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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9.发明授权DERIVATIVES OF N2-(3-PYRIDYL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES 有权用于治疗炎性，自身免疫疾病或增殖性病症Ñ2-（3-吡啶基或苯基）-N4-（哌啶-4-基）-2,4- PYRIMIDINEDIAMIN的合适的衍生物的治疗
公开(公告)号：EP2389373B1
公开(公告)日：2017-05-17
申请号：EP10701773.3
申请日：2010-01-21
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai , VALDEZ, Carlos , ZHANG, Jing , STAUFFER, Emily , DUNCTON, Matthew , ALVAREZ, Salvador
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , A61K31/506 , A61P37/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
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10.发明授权TETRAZOLONES AS PROTEIN KINASE C INHIBITORS AND USES THEREOF 有权TETRAZOLONE ALS PROTEINKINASE-C-HEMMER UND IHRE VERWENDUNG
公开(公告)号：EP2507227B1
公开(公告)日：2014-10-08
申请号：EP10796518.8
申请日：2010-12-01
发明人： SINGH, Rajinder , TSO, Kin , ZHANG, Jing , DUNCTON, Matthew , ALVAREZ, Salvador , KOLLURI, Rao , RAMPHAL, John , HOLLAND, Sacha
IPC分类号： C07D401/14 , C07D405/14 , A61K31/41 , A61P29/00
CPC分类号： C07D405/14 , A61K31/41 , A61K31/506 , C07D401/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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