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公开(公告)号：EP2079736A1
公开(公告)日：2009-07-22
申请号：EP07866124.6
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SYLVAIN, Catherine , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu
IPC分类号： C07D471/04 , C07D495/04 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D491/04
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/4355 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译： 公开了含有这些化合物的取代的三唑和药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
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公开(公告)号：EP1620412A2
公开(公告)日：2006-02-01
申请号：EP04751046.6
申请日：2004-04-30
发明人： SINGH, Rajinder , GOFF, Dane , PARTRIDGE, John, J.
IPC分类号： C07D263/32 , C07D271/06 , C07D275/02 , C07D277/10 , A61K31/00
CPC分类号： C07D231/12 , A61K31/00 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D275/02 , C07D277/28 , C07D285/12
摘要： The present invention relates to substituted diphenyl heterocycle compounds according to formula (I), (II), (III) and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections. Formula (I), (II), (III).
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3.发明公开PYRIDYL SUBSTITUTED HETEROCYCLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION 审中-公开吡啶基取代的杂环用于治疗或预防丙型肝炎病毒感染
公开(公告)号：EP1530569A2
公开(公告)日：2005-05-18
申请号：EP03793349.6
申请日：2003-08-22
发明人： SINGH, Rajinder , GOFF, Dane , PARTRIDGE, John
IPC分类号： C07D413/14 , C07D401/14 , C07D417/14 , C07D413/04 , C07D417/04 , C07D401/04 , A61K31/4439 , A61P31/12
CPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to pyridyl substituted heterocycles according to structural formula (I) or (II), or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof, wherein: the B ring is an aromatic or nonaromatic ring that includes from one to four heteroatoms, wherein X, Y, Z are each, independently of one another selected from C, CH, N, NR16, NR18, S or O, provided that X and Y are not bothe O; U and T are each, independently of one another, selected from C, CH or N; Z is N or CH-; A is N or -CR2-; B is N or -CR3-; D is N or -CR4-; E is N or -CR5 -; G is N or -CR6-; and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles and hydro isomers thereof and/or pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
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4.发明授权N3-HETEROARYL SUBSTITUTED TRIAZOLES AND N5-HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权N3-杂芳基取代的三唑和N5-杂芳基取代的三唑作为AXL抑制剂
公开(公告)号：EP2074115B1
公开(公告)日：2018-03-07
申请号：EP07866122.0
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D495/04 , C07D519/00 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D401/14 , C07D403/14
CPC分类号： C07D495/04 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： N 3 -Heteroaryl substituted triazoles and N 5 -heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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5.发明授权BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权BY桥双环芳基或 桥双环杂取代的三唑本身AS AXL抑制剂适合...
公开(公告)号：EP2114955B1
公开(公告)日：2013-02-13
申请号：EP07866125.3
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , DING, Pingyu , YU, Jiaxin , LITVAK, Joane
IPC分类号： C07D495/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D491/04 , C07D471/18 , C07D401/12 , C07D403/12 , C07D409/14
CPC分类号： C07D495/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/14 , C07D453/06 , C07D471/18
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6.发明公开POLYCYCLIC ARYL SUBSTITUTED TRIAZOLES AND POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权BY取代的三唑和多环杂芳基取代三唑本身AS AXL抑制剂SUITABLE环芳基
公开(公告)号：EP2205592A1
公开(公告)日：2010-07-14
申请号：EP07870108.3
申请日：2007-12-29
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D403/04 , C07D403/14 , C07D471/18 , C07D491/14 , A61K31/4196 , A61P19/00 , A61P35/00
CPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4375 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/08 , C07D471/18 , C07D491/14
摘要： Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
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7.发明公开
公开(公告)号：EP2078010A2
公开(公告)日：2009-07-15
申请号：EP07870107.5
申请日：2007-12-29
发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu , LITVAK, Joane
IPC分类号： C07D403/04 , C07D403/14 , C07D471/18 , C07D491/14 , A61K31/4196 , A61P19/00 , A61P35/00 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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8.发明公开
公开(公告)号：EP1597255A1
公开(公告)日：2005-11-23
申请号：EP03783609.5
申请日：2003-11-13
发明人： SINGH, Rajinder , RAMESH, Usha, V. , GOFF, Dane , LAIDIG, Guy , ISSAKANI, Sarkiz, D. , HUANG, Jianing , PAYAN, Donald, G. , CLOUGH, Jeffrey
IPC分类号： C07D417/06 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/06 , A61K31/40 , A61K31/41 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D417/14
摘要： This invention describes rhodanine derivatives and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating cell proliferative diseases such as cancers.
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公开(公告)号：EP2079736B1
公开(公告)日：2017-10-18
申请号：EP07866124.6
申请日：2007-12-28
发明人： GOFF, Dane , ZHANG, Jing , SYLVAIN, Catherine , SINGH, Rajinder , HOLLAND, Sacha , YU, Jiaxin , HECKRODT, Thilo , DING, Pingyu
IPC分类号： C07D471/04 , C07D495/04 , C07D487/04 , A61K31/4196 , A61P19/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D491/04
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/4355 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/635 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
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10.发明授权SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) 有权KLEINMOLEKÜL-HEMMER DER SPLEEN-TYROSINKINASE
公开(公告)号：EP2443123B1
公开(公告)日：2017-04-05
申请号：EP10790003.7
申请日：2010-06-14
发明人： ZHANG, Jing , SINGH, Rajinder , GOFF, Dane , KINOSHITA, Taisei
IPC分类号： C07D487/04 , C07D405/04 , A61K31/4162 , A61P37/02
CPC分类号： C07D487/04 , C07D405/04
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