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公开(公告)号：EP3010901A1
公开(公告)日：2016-04-27
申请号：EP14730544.5
申请日：2014-06-17
发明人： MENGEL, Anne , HITCHCOCK, Marion , RICHTER, Anja , BÄRFACKER, Lars , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D413/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物处理其生产和用作药物。
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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23.发明公开3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的3-氨基甲酰基苯基-4-甲酰胺和异鼠李素衍生物
公开(公告)号：EP3259263A1
公开(公告)日：2017-12-27
申请号：EP16704456.9
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William j. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D401/14 , C07D213/73 , C07D213/75 , C07D401/12 , A61K31/435 , A61P35/00 , C07C15/04
CPC分类号： A61K31/435 , C07C237/44 , C07D213/73 , C07D213/75 , C07D401/12 , C07D401/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.
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公开(公告)号：EP2885286B1
公开(公告)日：2017-03-22
申请号：EP13748072.9
申请日：2013-08-13
发明人： SIEGEL, Stephan , BÄURLE, Stefan , CLEVE, Arwed , HAENDLER, Bernard , FERNANDEZ-MONTALVAN, Amaury Ernesto , MÖNNING, Ursula , KRAUSE, Sabine , LEJEUNE, Pascale , SCHMEES, Norbert , BUSEMANN, Matthias , HOLTON, Simon , KUHNKE, Joachim
IPC分类号： C07D401/14 , C07D413/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/14 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/10 , C07D243/02 , A61K31/55 , A61P35/00 , A61P31/12
CPC分类号： C07D417/10 , A61K31/551 , A61K31/5513 , C07D243/02 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14
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公开(公告)号：EP3010902A1
公开(公告)日：2016-04-27
申请号：EP14730907.4
申请日：2014-06-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , BRIEM, Hans , LÜCKING, Ulrich , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , BAIRLEIN, Michaela , MÖNNING, Ursula , BRÜNING, Michael
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K45/06 , C07D401/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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26.发明公开1,3,4-THIADIAZOL-2-YL-BENZAMIDE DERIVATIVES AS INHIBITORSOF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的1,3,4-噻二唑-2-基苯甲酰胺衍生物
公开(公告)号：EP3259268A1
公开(公告)日：2017-12-27
申请号：EP16704644.0
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D417/12 , C07D417/14 , A61K31/454 , A61K31/496 , A61P35/00 , A61P37/02
CPC分类号： C07D285/135 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3194381A1
公开(公告)日：2017-07-26
申请号：EP15763929.5
申请日：2015-09-17
发明人： MENGEL, Anne , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNANDEZ-MONTALVAN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/14
摘要： Compounds of formula (I) and their use as pharmaceuticals.
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公开(公告)号：EP3194380A1
公开(公告)日：2017-07-26
申请号：EP15763928.7
申请日：2015-09-17
发明人： MENGEL, Anne , LERCHEN, Hans-Georg , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula , HOLTON, Simon
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D403/14 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceuticals.
摘要翻译： 式（I）化合物及其作为药物的用途。
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29.发明授权3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权3-乙酰氨基-1-（苯基 - 芳基 - 氨基羰基）苯基 - 邻苯二甲酰亚胺基）苯甲醛衍生物ZUR BEHANDLUNG VON HYPERPROLIFERATIVEN ERKRANKUNGEN
公开(公告)号：EP2976327B1
公开(公告)日：2017-06-21
申请号：EP14712631.2
申请日：2014-03-17
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/75 , C07D498/08 , C07D277/46 , C07D277/56 , C07D333/38 , C07D213/82 , C07D263/34 , C07D207/34 , C07D285/135 , C07D271/06 , C07D231/14 , C07D271/07 , C07D401/12 , C07D417/12 , C07D487/08 , C07D271/113 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/433 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5386 , A61K31/551 , A61K31/553 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/15 , C07C233/54 , C07C255/56 , C07C317/44 , C07D207/34 , C07D213/73 , C07D213/75 , C07D213/76 , C07D213/82 , C07D231/14 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D285/135 , C07D295/15 , C07D295/155 , C07D333/38 , C07D401/12 , C07D417/12 , C07D487/08 , C07D498/08
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公开(公告)号：EP2976335A1
公开(公告)日：2016-01-27
申请号：EP14711968.9
申请日：2014-03-20
发明人： HITCHCOCK, Marion , MENGEL, Anne , HILGER, Christoph-Stephan , BÄRFACKER, Lars , BRIEM, Hans , SIEMEISTER, Gerhard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUßE, Cornelia , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D417/14 , C07D498/04 , A61P9/10
CPC分类号： C07D401/14 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物处理其生产和用作药物。
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