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    GM1 GANGLIOSIDE TO ANNEXIN V MICROPARTICLE POLYPEPTIDE RATIO FOR BIOLOGICAL MONITORING
    26.
    发明公开
    GM1 GANGLIOSIDE TO ANNEXIN V MICROPARTICLE POLYPEPTIDE RATIO FOR BIOLOGICAL MONITORING 有权
    的关系神经节苷脂MIKROPARTIKELPOLYPEPTID和Annexin V MIKROPARTIKELPOLYPEPTID FOR生物监测

    公开(公告)号：EP2785734A4

    公开(公告)日：2015-11-11

    申请号：EP12853105

    申请日：2012-11-30

    申请人： AGENCY SCIENCE TECH & RES ,  SINGAPORE HEALTH SERV PTE LTD

    发明人： LIM SAI KIANG ,  TAN KOK HIAN

    IPC分类号： C07K14/47 ,  C12Q1/25 ,  G01N33/566

    CPC分类号： G01N33/689 ,  G01N33/5091 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2405/10 ,  G01N2800/32 ,  G01N2800/368 ,  G01N2800/52 ,  G01N2800/7028

    摘要： We describe a method of monitoring the state of a cell, tissue, organ or organism. The method comprises establishing, for a sample of microparticles from the cell, tissue, organ or organism, a ratio. The ratio is of a selected polypeptide in microparticles which comprise GM1 gangliosides, preferably which bind to Cholera Toxin B (CTB) (“GM1 ganglioside microparticle polypeptide”) to the selected polypeptide in microparticles which comprise exposed phosphotidylserine, preferably which bind to Annexin V (“Annexin V microparticle polypeptide”). The GM1 ganglioside microparticle polypeptide to Annexin V microparticle polypeptide ratio so established may be indicative of the state of the cell, tissue, organ or organism.

    摘要翻译： 我们描述一种监测细胞，组织，器官或生物体状态的方法。 该方法包括对来自细胞，组织，器官或生物体的微粒样品的比例建立一个比例。 该比例是包含GM1神经节苷脂的微粒中所选择的多肽，其优选结合霍乱毒素B（CTB）（“GM1神经节苷脂微粒多肽”）对包含暴露的磷脂酰丝氨酸的微粒中所选择的多肽，优选结合膜联蛋白V（ “膜联蛋白V微粒多肽”）。 GM1神经节苷脂微粒多肽对Annexin V微粒多肽的比例如此建立可以指示细胞，组织，器官或生物体的状态。

    BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS
    27.
    发明公开
    BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS 有权
    FLUORESZENZSONDEN MIT BODIPY-STRUKTURFÜRVERSCHIEDENE BIOLOGISCHE ANWENDUNGEN

    公开(公告)号：EP2794620A4

    公开(公告)日：2015-09-02

    申请号：EP12859000

    申请日：2012-12-20

    申请人： UNIV SINGAPORE ,  AGENCY SCIENCE TECH & RES

    发明人： CHANG YOUNG-TAE ,  LEE SUNG CHAN ,  KANG NAM-YOUNG ,  YUN SEONG WOOK ,  LEONG CHERYL KIT MUN ,  HA HYUNG HO

    IPC分类号： C07F5/02 ,  G01N33/533

    CPC分类号： G01N33/5306 ,  A61K49/0021 ,  A61K49/006 ,  C07F5/02 ,  C07F5/022 ,  G01N33/56966 ,  G01N33/582 ,  G01N2458/00

    摘要： The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.

    摘要翻译： 本发明涉及由结构式（I）表示的对神经干细胞特异性的荧光化合物：（I）或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了用于检测β细胞，胰岛和小神经胶质细胞的方法，包括使用结构式（I）的化合物或其药学上可接受的盐。 结构式（I）的化合物还可以将健康胰岛细胞与糖尿病胰岛细胞分化。