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107 条记录 (耗时 0.021 秒)

    A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME
    24.
    发明公开
    A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 有权
    诊断和治疗方法及合适的方法

    公开(公告)号：EP1866647A1

    公开(公告)日：2007-12-19

    申请号：EP06721313.2

    申请日：2006-03-31

    申请人： MEDVET SCIENCE PTY. LTD.

    发明人： BROWN, Michael, Paul

    IPC分类号： G01N33/574 ,  G01N33/53 ,  G01N33/577 ,  A61K51/10 ,  A61K39/395 ,  A61P35/00 ,  C12Q1/68

    CPC分类号： G01N33/573 ,  C07K16/40 ,  G01N33/5011 ,  G01N33/57488 ,  G01N2800/52

    摘要： The present invention relates generally to a method of screening for the level of neoplastic cell death in a subject. More particularly, the present invention provides a method of screening for the level of neoplastic cell death by detecting the level of expression of telomerase protein and/or gene by dead cells in said subject or in a biological sample derived from said subject. The method of the present invention is useful in a range of applications including, but not limited to, assessing a neoplastic condition, monitoring the progression of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regime and predicting the likelihood of a subject either progressing to a more advanced disease state or entering a remissive state. The present invention also provides diagnostic agents useful for detecting telomerase protein and/or nucleic acid molecules.

    METHOD OF MODULATING CELLULAR ACTIVITY INVOLVING SPHINGOSINE KINASE AND AGENTS FOR SAME, AND SPHINGOSINE KINASE VARIANTS
    27.
    发明公开
    METHOD OF MODULATING CELLULAR ACTIVITY INVOLVING SPHINGOSINE KINASE AND AGENTS FOR SAME, AND SPHINGOSINE KINASE VARIANTS 审中-公开
    方法的细胞活性与鞘氨醇及代理人，以及它们的鞘氨醇变异调制

    公开(公告)号：EP1765384A1

    公开(公告)日：2007-03-28

    申请号：EP05750186.8

    申请日：2005-06-15

    申请人： MEDVET SCIENCE PTY. LTD.

    发明人： PITSON, Stuart, M. ,  VADAS, Mathew, Alexander ,  XIA, Pu ,  MORETTI, Paul, A. ,  LECLERCQ, Tamara ,  SUTHERLAND, Catherine

    IPC分类号： A61K38/43 ,  A61K38/18 ,  A61K38/19 ,  A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  C12N9/12

    CPC分类号： C12N9/1205 ,  A61K38/1709

    摘要： The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating cellular activity by modulating intracellular translocation of sphingosine kinase to the cell membrane. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular translocation and agents for use therein. The present invention still further extends to sphingosine kinase variants and to functional derivatives, homologues and analogues thereof, exhibiting ablated or reduced capacity to undergo translocation. The method and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating sphingosine kinase intracellular translocation.

    MICROBIAL STREAKING DEVICE
    28.
    发明公开
    MICROBIAL STREAKING DEVICE 有权
    VORRICHTUNG ZUM AUSSTREICHEN VON MIKROBEN

    公开(公告)号：EP1720971A4

    公开(公告)日：2007-01-24

    申请号：EP05700111

    申请日：2005-01-21

    申请人： MEDVET SCIENCE PTY LTD

    发明人： GLASSON JOHN ,  SMITH LACHLAN

    IPC分类号： C12M1/26 ,  C12M1/32

    CPC分类号： C12M33/02

    摘要： A streaker device for streaking a microbial inoculum for single colonies on the surface of a solid growth medium. The streaking device has a row of spaced apart contact surfaces for contact with the surface of the solid growth medium. The spaced apart contact surfaces are resiliently flexibly supported by a common support member so as to accommodate variations in depth of growth medium. The spaced apart contact surfaces may be provided on lowermost part of axially curved portions of plastics straps, that are angled backwardly. It is found that formation of a single band can give separation into single colonies. Also provided is an automatic streaking apparatus.

    摘要翻译： 用于在固体生长培养基表面上单菌落划线的微生物接种物的划痕器。 拖尾装置具有用于与固体生长培养基的表面接触的一排间隔开的接触表面。 间隔开的接触表面由共同的支撑构件弹性地柔性地支撑，以适应生长介质深度的变化。 间隔开的接触表面可以设置在向后成角度的塑料带的轴向弯曲部分的最下部分上。 发现单一带的形成可以分离成单个菌落。 还提供了自动划线装置。

    A METHOD OF MODULATING EPITHELIAL CELL ACTIVITY BY MODULATING THE FUNCTIONAL LEVELS OF SPHINGOSINE KINASE
    29.
    发明公开
    A METHOD OF MODULATING EPITHELIAL CELL ACTIVITY BY MODULATING THE FUNCTIONAL LEVELS OF SPHINGOSINE KINASE 审中-公开
    调制EPITHELZELLAKTIVITÄT方法由穿梭鞘氨醇功能水平的变化

    公开(公告)号：EP1558736A4

    公开(公告)日：2006-05-10

    申请号：EP03750156

    申请日：2003-10-14

    申请人： MEDVET SCIENCE PTY LTD

    发明人： GAMBLE JENNIFER RUTH ,  VADAS MATHEW ,  PITSON STUART ,  XIA PU ,  LIMAYE VIDYA

    IPC分类号： A61K38/45 ,  C12N9/12 ,  C12N15/12 ,  A61K48/00 ,  C12N5/16 ,  C12N15/63

    CPC分类号： C12N9/1205 ,  A61K38/45 ,  C12N2799/022

    摘要： The present invention relates generally to a method of modulating endothelial cell functional characteristics and to agents useful for same. More particularly, the present invention relates to a method of modulating vascular endothelial cell pro-inflammatory and angiogenic phenotypes by modulating the functional levels of intracellular sphingosine kinase. The method of the present invention is useful, inter alia, in relation to the treatment and/or prophylaxis of conditions which are characterised by inadequate endothelial cell functioning and may include conditions such as vascular engraftment, organ transplantation or wound healing or conditions which are characterised by an aberrant endothelial cell inflammatory or angiogenic phenotype. Further, the method of the present invention facilitates the development of agents, such as functionally manipulated endothelial cell populations, for a range of therapeutic and/or prophylactic uses.

    A METHOD OF DIAGNOSIS AND TREATMENT
    30.
    发明公开
    A METHOD OF DIAGNOSIS AND TREATMENT 有权
    方法进行诊断和治疗

    公开(公告)号：EP1599226A1

    公开(公告)日：2005-11-30

    申请号：EP04713491.1

    申请日：2004-02-23

    申请人： MEDVET SCIENCE PTY. LTD.

    发明人： BROWN, Michael, Paul

    IPC分类号： A61K39/385 ,  A61K39/44 ,  A61K49/00 ,  A61P35/00

    CPC分类号： G01N33/57488 ,  A61K47/6843 ,  A61K51/1018 ,  C07K16/18 ,  G01N33/5017 ,  G01N33/6875 ,  G01N2510/00

    摘要： The present invention relates generally to a method for detecting an aberrant cell, and more particularly an apoptotic cell, in a subject or in a biological sample from said subject, and agents useful for same. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting an apoptotic cell by detecting the presence of extranuclear nuclear molecules, in particular La, or a relative increase in extranuclear nuclear molecule levels. The present invention further provides a method for diagnosing or monitoring conditions characterised by aberrant, unwanted or otherwise inappropriate cellular apoptosis in a subject or in a biological sample from said subject by screening for up-regulation of extranuclear nuclear molecule levels in a cell or group of cells. The present invention provides diagnostic agents useful for detecting these molecules. Such diagnostic agents include immunointeractive molecules, such as antibodies.