摘要:
This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided.
摘要:
The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof.
摘要:
Method and apparatus for storing heat in industrial systems where large sources of stored energy are called upon to meet a work load, storing the heat content of a hot working fluid by using the hot working fluid as a heat transfer fluid in vapor form and depositing its heat content on a heat storage medium and then removing the cooled and condensed liquid phase of that heat transfer fluid, and when hot working fluid again is needed, the liquid heat transfer fluid is returned to the heated storage medium and is reheated as it passes through the hot storage medium and then is returned to the working system to be used as a hot working fluid.
摘要:
An optimal path routing method is provided for transmitting data from a source node to a destination node. The optimal path setting method includes transmitting a shortcut request (SCRQ) message from the source node to a topology server; determining shortcut information at the topology server based on the SCRQ message; and transmitting a shortcut notification (SCNF) message containing the shortcut information from the topology server to the destination node.
摘要:
A laser medium includes a single crystal of chromium-doped LiSc1-xInxGe1-ySiyO4, where O≤x≤l and O≤y≤l . Preferably, x and y are not both 0. A laser, such as a tunable near infrared laser, can contain the laser medium.
摘要:
In one embodiment, the invention relates to a method for rendering a non-metallic substrate stably antimicrobial. The method comprises: (a) contacting the substrate with an antimicrobial surfactant; (b) contacting the substrate with a polymeric binder; and (c) subjecting the substrate, surfactant, and binder to conditions at which the substrate becomes stably antimicrobial. In another embodiment, the invention relates to a substrate into which an antimicrobial surfactant and a binder have penetrated.
摘要:
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for developing transcranial electrical stimulation protocols are disclosed. In one aspect, a method includes the actions of accepting an image model of target tissue, obtaining a forward model having a first electrode configuration and first electrical stimulation parameters based on electrical stimulation of the target tissue, accepting electrode configuration changes or electrical stimulation parameter changes resulting in a second electrode configuration or second electrical stimulation parameters, determining an optimized tissue model using a least square methodology and based on the second electrode configuration or second electrical stimulation parameter changes, comparing the optimized tissue model with a desired outcome, and providing a confirmation of the optimized model with the desired outcome.
摘要:
The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
摘要:
A routing method in the wireless network and a communication device using the same is provided. The routing method in the tree-based wireless network includes acquiring an optimal route using a table which is recorded based on received information on neighbor nodes and received information on lower nodes of the neighbor nodes, and transmitting a packet through the optimal route. Accordingly, tree-based mesh routing which performs route discovery block by block is used in order to increase the efficiency of route discovery, and a packet is transmitted through an optimal route so that communication costs can be reduced.
摘要:
Provided herein are novel syntheses of the phosphate-based inositol derivatives 1-O-[(+)-menthoxycarbonyl]-6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol (D4P), D-myo-inositol 1,4,5-triphosphate (D-IP3), 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate (3-HP) and L-myo-inositol 1,4,5-triphosphate (L-IP3). These syntheses employ fewer column chromatography steps for the isolation of intermediates than do prior art syntheses, and hence, are more convenient, economical and efficient than are the previously known synthetic methods.