公开(公告)号：EP2056858B1

公开(公告)日：2014-06-25

申请号：EP07784767.1

申请日：2007-08-10

Applicant: CSL Limited

Inventor： CRUMP, David, Eric ,  NASH, Andrew, Donald

IPC: A61K38/18 ,  A61K48/00 ,  A61K39/395 ,  A61P11/00 ,  A01K67/027 ,  A61K38/17 ,  C07K14/535 ,  C07K16/24 ,  A61K39/00

CPC classification number: C12N15/1138 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/0368 ,  A61K38/1793 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/535 ,  C07K16/22 ,  C07K16/243 ,  C07K16/2863 ,  C07K2317/73 ,  C12N15/1136

公开(公告)号：EP2677863A1

公开(公告)日：2014-01-01

申请号：EP12707063.9

申请日：2012-02-23

Applicant: Université Catholique de Louvain

Inventor： DUFRANE, Denis ,  VERITER, Sophie ,  GIANELLO, Pierre

IPC: A01N1/02 ,  A61K35/39 ,  A61K48/00 ,  C07K14/605 ,  C12N5/071

CPC classification number: A61K35/39 ,  A01K67/027 ,  A01K67/0275 ,  A01K2207/20 ,  A01K2217/052 ,  A01K2227/108 ,  A01K2267/025 ,  C07K14/605 ,  C12N5/0676 ,  C12N15/8509

Abstract: The present invention relates to a modified pig islet capable of producing higher levels of glucagon than a native pig islet or capable of producing a glucagon analog, and methods for obtaining thereof. The invention also relates to a method for treating Diabetes Mellitus, and/or for regulating blood glucose levels in a subject in need thereof, comprising the administration of the modified pig islets of the invention.

公开(公告)号：EP2460403A4

公开(公告)日：2013-11-20

申请号：EP09847838

申请日：2009-07-31

Applicant: STELIC INST OF REGENERATIVE MEDICINE STELIC INST & CO

Inventor： YONEYAMA HIROYUKI ,  FUJII MASATO

IPC: A01K67/027

CPC classification number: A01K67/027 ,  A01K2207/20 ,  A01K2207/25 ,  A01K2227/10 ,  A01K2267/0331

Abstract: Fatty liver was induced by administering agents for inducing organ inflammation to experimental animals to evoke insulin resistance and by rearing them with high-fat diets. As a result, steatohepatitis was successfully induced in the animals. The animals show pathological findings similar to those of humans. By using these model animals, substances for treating or preventing diseases can be efficiently screened and the efficacy of medicinal substances can be effectively evaluated.

公开(公告)号：EP2597945A2

公开(公告)日：2013-06-05

申请号：EP11815063.0

申请日：2011-07-26

Applicant: Trianni, Inc.

Inventor： WABL, Matthias ,  KILLEEN, Nigel

IPC: A01K67/027

CPC classification number: A01K67/0278 ,  A01K67/027 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  C12N15/00 ,  C12N15/8509 ,  C12N2800/30 ,  C12P21/00

Abstract: The present invention comprises non-human vertebrate cells and non-human mammals having a genome comprising an introduced partially human immunoglobulin region, said introduced region comprising human VH coding sequences and non-coding VH sequences based on the endogenous genome of the non-human mammal.

公开(公告)号：EP2569431A1

公开(公告)日：2013-03-20

申请号：EP11720710.0

申请日：2011-05-13

Applicant: Sarepta Therapeutics, Inc.

Inventor： SCHNELL, Frederick, J. ,  IVERSEN, Patrick, L. ,  MOURICH, Dan, V.

IPC: C12N15/113 ,  A61P29/00 ,  A61K31/713

CPC classification number: A61K31/713 ,  A01K67/027 ,  A01K2267/03 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/33 ,  G01N33/5041 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/005 ,  G01N2333/54 ,  G01N2500/00 ,  Y02A50/414

Abstract: Provided are antisense oligonucleotides and other agents that target and modulate IL-17 and/or IL-23 signaling activity in a cell, compositions that comprise the same, and methods of use thereof. Also provided are animal models for identifying agents that modulate 17 and/or IL-23 signaling activity.

公开(公告)号：EP2549859A1

公开(公告)日：2013-01-30

申请号：EP11709745.1

申请日：2011-03-24

Applicant: Institut National De La Sante Et De La Recherche Medicale

Inventor： CHEMIN, Isabelle ,  TREPO, Christian

IPC: A01K67/027 ,  C07K14/18 ,  C12N7/00

CPC classification number: A01K67/027 ,  A01K2227/106 ,  A01K2267/0337 ,  C07K14/005 ,  C12N7/00 ,  C12N2730/10121

Abstract: The invention relates to a non-human primate animal model for HBV infection, said animal model being of the Cercopithecidae family.

公开(公告)号：EP2448967A4

公开(公告)日：2012-12-05

申请号：EP10794608

申请日：2010-06-28

Applicant: LESKOV ILYA B ,  DRAKE ADAM C ,  KHOURY MAROUN ,  CHEN JIANZHU ,  PALLASCH CHRISTIAN ,  HEMANN MICHAEL

Inventor： LESKOV ILYA B ,  DRAKE ADAM C ,  KHOURY MAROUN ,  CHEN JIANZHU ,  PALLASCH CHRISTIAN ,  HEMANN MICHAEL

IPC: A01K67/027 ,  A61K39/395 ,  C07K16/00

CPC classification number: A61K39/3955 ,  A01K67/027 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0381 ,  A61K2039/505 ,  C07K16/2893 ,  C07K2317/24 ,  A61K2300/00

公开(公告)号：EP2327299B1

公开(公告)日：2012-05-16

申请号：EP09833276.0

申请日：2009-10-07

Applicant: Astellas Pharma Inc.

Inventor： NAGAKURA, Yukinori ,  OE, Tomoya

IPC: A01K67/027

CPC classification number: G01N33/5088 ,  A01K67/027 ,  A01K2227/105 ,  A01K2267/035 ,  G01N2800/2842

Abstract: A disease model animal characterized by being produced by applying a treatment for decreasing the amine level in a body to a mammal to induce chronic pain in the mammal; and a method for screening for a therapeutic agent for chronic pain, which is characterized by administering a substance to be examined to the disease model animal.

公开(公告)号：EP2403937A2

公开(公告)日：2012-01-11

申请号：EP10749294.4

申请日：2010-03-03

Applicant: The Regents of the University of Michigan

Inventor： ZACKS, David Noam

IPC: C12N5/02 ,  C07K14/54 ,  A61K38/20 ,  A61P27/02

CPC classification number: A61K38/204 ,  A01K67/027 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/035 ,  A61K9/0048 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1761 ,  A61K38/179 ,  A61K48/00 ,  C07K14/4703 ,  C07K14/5412 ,  C12N2799/025

Abstract: The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis.

公开(公告)号：EP2326174A4

公开(公告)日：2011-11-30

申请号：EP09807297

申请日：2009-08-13

Applicant: HARVARD COLLEGE

Inventor： CEPKO CONSTANCE L ,  CHEN BO

IPC: A01N43/04 ,  A61K31/70

CPC classification number: C07K14/4702 ,  A01K67/027 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K48/00 ,  A61K2039/53 ,  C12N9/16 ,  C12N15/63 ,  C12N15/67 ,  C12N15/85 ,  C12N2799/025