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公开(公告)号：EP2770823A2
公开(公告)日：2014-09-03
申请号：EP12843651.6
申请日：2012-10-26
申请人： Trianni Inc.
发明人： KILLEEN, Nigel
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2227/105 , A01K2267/03
摘要： This invention relates to transgenic vertebrates, and more specifically to transgenic vertebrates for the development of human therapeutics.
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公开(公告)号：EP3384030A1
公开(公告)日：2018-10-10
申请号：EP16871431.9
申请日：2016-11-30
申请人： Trianni, Inc.
发明人： WABL, Matthias , DUONG, Bao , KILLEEN, Nigel
CPC分类号： C12P21/00 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/00 , C07K2317/52 , C07K2317/60
摘要： The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.
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公开(公告)号：EP3340786A1
公开(公告)日：2018-07-04
申请号：EP16840040.6
申请日：2016-08-24
申请人： Trianni, Inc.
发明人： WABL, Matthias , KILLEEN, Nigel
IPC分类号： A01K67/027 , A61K39/395 , C07K16/00 , C12N15/13
CPC分类号： C07K16/468 , A01K67/0275 , A01K2217/07 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K2317/20 , C07K2317/31
摘要： The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.
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公开(公告)号：EP2597945A2
公开(公告)日：2013-06-05
申请号：EP11815063.0
申请日：2011-07-26
申请人： Trianni, Inc.
发明人： WABL, Matthias , KILLEEN, Nigel
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K67/027 , A01K2217/07 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C12N15/00 , C12N15/8509 , C12N2800/30 , C12P21/00
摘要： The present invention comprises non-human vertebrate cells and non-human mammals having a genome comprising an introduced partially human immunoglobulin region, said introduced region comprising human VH coding sequences and non-coding VH sequences based on the endogenous genome of the non-human mammal.
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公开(公告)号：EP4414484A2
公开(公告)日：2024-08-14
申请号：EP24170934.4
申请日：2017-02-03
申请人： Trianni, Inc.
IPC分类号： C40B40/10
CPC分类号： A01K67/0278 , C07K16/42 , A01K2217/07220130101 , C07K16/00 , C12N5/0635 , C12N5/12 , C07K2317/62220130101 , A01K2267/0120130101 , A01K2227/10520130101 , C12N2510/0220130101 , C12N5/16 , C07K14/31 , C07K2319/0020130101 , C07K2319/0220130101 , C07K2319/0320130101
摘要： The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
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公开(公告)号：EP2597945B1
公开(公告)日：2020-07-22
申请号：EP11815063.0
申请日：2011-07-26
申请人： Trianni, Inc.
发明人： WABL, Matthias , KILLEEN, Nigel
IPC分类号： A01K67/027 , C07K16/00 , C12N15/85
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公开(公告)号：EP3411476A1
公开(公告)日：2018-12-12
申请号：EP17748280.9
申请日：2017-02-03
申请人： Trianni, Inc.
IPC分类号： C12N5/10 , A61K35/17 , A61K47/62 , A61K47/65 , A61K39/395 , C12Q1/68 , C40B40/06 , C40B40/08 , C40B40/10
CPC分类号： C07K14/315 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K14/70503 , C07K14/70514 , C07K14/70539 , C07K14/70596 , C07K16/00 , C07K16/42 , C07K2317/14 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0635 , C12N5/12 , C12N2510/02
摘要： The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.
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