公开(公告)号：EP2173297A2

公开(公告)日：2010-04-14

申请号：EP08796288.2

申请日：2008-07-18

申请人： MARINE POLYMER TECHNOLOGIES, INC. ,  The Brigham and Women's Hospital, INC.

发明人： ORGILL, Dennis, P. ,  PIETRAMAGGIORI, Giorgio ,  FINKIELSZTEIN, Sergio ,  VOURNAKIS, John, N.

IPC分类号： A61F13/02 ,  A61M1/00 ,  A61M27/00

CPC分类号： A61M1/0088 ,  A61F13/00012 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/0206 ,  A61F13/0216 ,  A61F13/022 ,  A61F13/0223 ,  A61F13/0226 ,  A61F2013/00174 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/00927

摘要： This invention relates in general to a method and device for facilitating hemostasis and wound healing. In particular, the invention relates to the device comprising a polymeric material disposed on a scaffold that facilitates hemostasis and wound healing. Specifically, the invention contemplates the use of such scaffolds in conjunction with a negative pressure device.

公开(公告)号：EP0683679A1

公开(公告)日：1995-11-29

申请号：EP94907550.0

申请日：1994-02-11

申请人： FIDIA ADVANCED BIOPOLYMERS S.R.L.

发明人： DORIGATTI, Franco ,  CALLEGARO, Lanfranco

IPC分类号： A61F13 ,  A61L15 ,  D06M16

CPC分类号： D06M16/00 ,  A61F13/00012 ,  A61F13/00017 ,  A61F13/00063 ,  A61F2013/00097 ,  A61F2013/00229 ,  A61F2013/00263 ,  A61F2013/00476 ,  A61F2013/00523 ,  A61F2013/00744 ,  A61F2013/00876 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61F2013/00931 ,  A61L15/28 ,  Y10T428/24124 ,  C08L5/08

摘要： Provided is a multilayer nonwoven material, comprising a surface layer which comes into contact with the skin, and one or more other layers which do not come into contact with the skin, wherein said surface layer which comes into contact with the skin is a member selected from the group consisting of a surface layer comprising at least one derivative of hyaluronic acid, a surface layer comprising a mixture of said at least one derivative of hyaluronic acid and at least one natural polymer, semisynthetic polymer, or synthetic polymer, and a surface layer comprising a natural, synthetic, or semisynthetic biocompatible perforated membrane compatible with cell growth on its surface. The derivative of hyaluronic acid can be a hyaluronic acid ester. This material can be employed in a wide variety of medical and sanitary applications, including surgery and as a non-adhesive covering material.

公开(公告)号：EP0227955A3

公开(公告)日：1987-11-25

申请号：EP86116467

申请日：1983-07-20

申请人： University of Strathclyde

发明人： Juhasz, Laszlo

IPC分类号： A61L15/01 ,  A61F13/00

CPC分类号： A61N1/205 ,  A61F13/00012 ,  A61F13/069 ,  A61F13/51121 ,  A61F13/534 ,  A61F13/8405 ,  A61F2013/00157 ,  A61F2013/00217 ,  A61F2013/00221 ,  A61F2013/00229 ,  A61F2013/00519 ,  A61F2013/15024 ,  A61F2013/15048 ,  A61F2013/53445 ,  A61K9/7023 ,  A61L15/24 ,  A61L15/26 ,  A61L15/28 ,  A61L15/325 ,  A61F13/00 ,  C08L5/04 ,  C08L23/12

摘要： The multilayered composite wound dressing comprises of a semipermeable membrane (10), optionally with a permeable supporting and reinforcing layer, and a non-­stick, self-sealing biodegradable tissue interface (11). The semipermeable membrane may be a synthetic collagen, an alginate or a biocompatible polymer and it controls the rate of water vapour transmission from the wound surface. The permeable supporting and reinforcing layer provides mechanical strength and is usually a textile fabric. The biodegradable tissue interface may be synthetic collagen, sodium-calcium alginate or collagen-­alginate complex, and it provides non-stick haemostatic sealing and aids the wound repair processes. For topical medication, growth promoting, antibacterial, anti­allergic and therapeutic agents may also be incorporated.

摘要翻译： 多层复合伤口敷料包括半透膜，透气性支撑和增强层，以及不粘，自密封的可生物降解的组织界面。 半透膜可以是合成胶原，藻酸盐或生物相容性聚合物，并且它控制从伤口表面传递水蒸气的速率。 可渗透的支撑和增强层提供机械强度，并且通常是纺织织物，其也可以通过用掺碳的硅或天然橡胶涂布或在织物上沉积金属而被制成导电的。 或者，也可以使用活性炭布织物。 可生物降解的组织界面可以是合成胶原，藻酸钠钙或胶原 - 藻酸盐复合物，并且它提供不粘的止血密封并辅助伤口修复过程。 对于局部用药，还可以引入生长促进剂，抗细菌剂，抗过敏剂和治疗剂。 适用于特定层的每种材料的任何组合可用于特定应用。 导电支撑和增强层可以用于使用已经显示出增强伤口愈合过程，产生术后疼痛缓解和细菌抑制的外部场的电荷传递和刺激。 复合伤口敷料尤其适用于治疗一般手术伤口，烧伤，褥疮，感染性溃疡，皮肤移植物的供体部位，或者可用于经皮和功能性刺激中的电极敷料。

公开(公告)号：EP0227955A2

公开(公告)日：1987-07-08

申请号：EP86116467.1

申请日：1983-07-20

申请人： University of Strathclyde

发明人： Juhasz, Laszlo

IPC分类号： A61L15/01 ,  A61F13/00

CPC分类号： A61N1/205 ,  A61F13/00012 ,  A61F13/069 ,  A61F13/51121 ,  A61F13/534 ,  A61F13/8405 ,  A61F2013/00157 ,  A61F2013/00217 ,  A61F2013/00221 ,  A61F2013/00229 ,  A61F2013/00519 ,  A61F2013/15024 ,  A61F2013/15048 ,  A61F2013/53445 ,  A61K9/7023 ,  A61L15/24 ,  A61L15/26 ,  A61L15/28 ,  A61L15/325 ,  A61F13/00 ,  C08L5/04 ,  C08L23/12

摘要： The multilayered composite wound dressing comprises of a semipermeable membrane (10), optionally with a permeable supporting and reinforcing layer, and a non-­stick, self-sealing biodegradable tissue interface (11). The semipermeable membrane may be a synthetic collagen, an alginate or a biocompatible polymer and it controls the rate of water vapour transmission from the wound surface. The permeable supporting and reinforcing layer provides mechanical strength and is usually a textile fabric. The biodegradable tissue interface may be synthetic collagen, sodium-calcium alginate or collagen-­alginate complex, and it provides non-stick haemostatic sealing and aids the wound repair processes. For topical medication, growth promoting, antibacterial, anti­allergic and therapeutic agents may also be incorporated.

摘要翻译： 所述多层复合伤口敷料包括半透膜（10），任选地具有可渗透的支撑和增强层，以及不粘的，自密封的可生物降解的组织界面（11）。 半透膜可以是合成胶原，藻酸盐或生物相容性聚合物，并且它控制从伤口表面传递水蒸气的速率。 可渗透的支撑和增强层提供机械强度，并且通常是纺织织物。 可生物降解的组织界面可以是合成胶原，藻酸钠钙或胶原 - 藻酸盐复合物，并且它提供不粘的止血密封并辅助伤口修复过程。 对于局部用药，还可以引入生长促进剂，抗细菌剂，抗过敏剂和治疗剂。

公开(公告)号：EP3377682A1

公开(公告)日：2018-09-26

申请号：EP15801217.9

申请日：2015-11-18

申请人： Advanced Medical Solutions Limited

发明人： BRADFORD, Colin Raymond ,  HORRIDGE, David

IPC分类号： D01D5/06 ,  D01F2/28 ,  D01F9/04

CPC分类号： A61L15/60 ,  A61F13/00008 ,  A61F13/00012 ,  A61L15/28 ,  A61L26/0023 ,  D01D5/06 ,  D01F2/28 ,  D01F9/04 ,  D04H1/42

摘要： Fibres suitable for use in the production of wound dressings comprise carboxymethyl cellulose and alginate in a total amount of at least 90% by weight of the fibre, the carboxymethyl cellulose and alginate are homogeneously distributed throughout the fibre and are present in amounts such that: (a) the amount of carboxymethyl cellulose present in the fibre is at least 50% by weight of the total weight of the carboxymethyl cellulose and alginate; (b) the alginate has a Guluronate-content of 50-90% by weight, and (c) the value of z given by the expression (1): z=(2x/40)/(2x/40)+(y/23) where x and y are the percentages by weight of calcium and sodium respectively in the fibres is at least 80. The fibres may be produced by spinning a solution comprising dissolved CMC and alginate in appropriate proportions into a coagulation bath containing calcium ions.

公开(公告)号：EP3369438A1

公开(公告)日：2018-09-05

申请号：EP16860276.1

申请日：2016-10-28

申请人： CG Bio Co., Ltd. ,  The Asan Foundation

发明人： PARK, Hee Jun ,  RYU, Hyun Seung ,  HONG, Joon Pio ,  SEO, Jun Hyuk ,  PARK, Jong Ha ,  HONG, Soon Gee ,  JANG, Hak Su ,  LEE, So Myoung ,  YOO, Bo Young

IPC分类号： A61L15/40 ,  A61L15/28 ,  A61F13/00

CPC分类号： A61L15/32 ,  A61F13/00 ,  A61F13/00012 ,  A61L15/28 ,  A61L15/40 ,  C07K14/78 ,  C08L5/08 ,  C08L2201/06 ,  C08L2203/02

摘要： The present invention relates to a wound dressing material comprising a fibrillated acellular dermis matrix and a biodegradable polymer aqueous solution and, more specifically, to: a wound dressing material comprising 5-20 wt% of a fibrillated acellular dermis matrix, 0.5-5 wt% of a biodegradable polymer, and 75-94.5 wt% of water; and a preparation method therefor.

公开(公告)号：EP3347510A1

公开(公告)日：2018-07-18

申请号：EP16766900.1

申请日：2016-09-09

申请人： Bauerfeind AG

发明人： BAUERFEIND, Hans B.

IPC分类号： D01F1/10

CPC分类号： D01F1/10 ,  A41B1/08 ,  A41B9/001 ,  A41B11/00 ,  A41D1/04 ,  A41D1/08 ,  A61F13/00012 ,  A61F13/00017 ,  A61F13/08 ,  A61L15/225 ,  A61L15/44 ,  A61L2300/418 ,  D04H1/08 ,  D10B2201/22 ,  D10B2201/24 ,  D10B2331/02 ,  D10B2331/04 ,  D10B2401/12 ,  D10B2501/021 ,  D10B2501/04 ,  D10B2509/02

摘要： The invention relates to a polymer composition containing a polymer and at least one active substance, moulded body comprising said type of polymer composition, to the use of the moulded body and polymer compositions and corresponding yarns, non-woven fabrics, garments and medicinal auxiliary agents.

公开(公告)号：EP2575905B1

公开(公告)日：2018-05-30

申请号：EP11721057.5

申请日：2011-05-24

申请人： Université de Liège

发明人： FILEE, Patrice ,  FREICHELS, Astrid ,  JEROME, Christine ,  AQIL, Abdelhafid ,  COLIGE, Alain ,  TCHEMTCHOUA TATEU, Victor

IPC分类号： A61L15/64 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L27/20 ,  A61L27/48 ,  A61F13/00 ,  A61L15/28 ,  A61L15/42

CPC分类号： A61F13/00008 ,  A61F13/00012 ,  A61F13/00063 ,  A61L15/28 ,  A61L15/425 ,  A61L15/64 ,  A61L27/20 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2400/12 ,  C08L5/08

摘要： The invention concerns chitosan-based biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan-based scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one layer consists of a chitosan nanofiber scaffold membrane and at least one of the other layers of a porous chitosan scaffold support layer. Moreover, the present invention provides a layered chitosan-based scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan-based scaffold.Finally, the present invention provides the use of the layered electrospun chitosan-based scaffold of the invention or the layered electrospun chitosan-based scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.

公开(公告)号：EP2381968B1

公开(公告)日：2018-05-09

申请号：EP09836582.8

申请日：2009-11-06

申请人： Collagen Matrix, Inc.

发明人： LI, Shu-Tung ,  LEE, Natsuyo Shishido ,  YUEN, Debbie

IPC分类号： A61L15/32 ,  A61L15/28 ,  A61K9/70 ,  A61K9/00 ,  A61K47/42 ,  A61F13/00 ,  A61L15/14

CPC分类号： A61K9/0014 ,  A61F13/00012 ,  A61F13/00034 ,  A61K47/42 ,  A61L15/14 ,  A61L15/28 ,  A61L15/32 ,  A61L15/325

摘要： The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.

公开(公告)号：EP3139877A1

公开(公告)日：2017-03-15

申请号：EP15720670.7

申请日：2015-04-28

申请人： Paul Hartmann AG

发明人： DEIBLER, Martin ,  HACKEL, Kristin

IPC分类号： A61F13/00

CPC分类号： A61F13/00008 ,  A61F13/00012 ,  A61F13/00017 ,  A61F13/00029 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2013/00251 ,  A61F2013/00255 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00604 ,  A61F2013/00634

摘要： The present invention relates to a wound dressing for use in vacuum therapy of wounds, comprising a first layer composed of a first porous foam, a second layer composed of a second porous foam, wherein the second layer is connected non-releasably to the first layer, a multiplicity of through-openings which pass like channels all the way through both layers, characterized in that the first foam differs from the second foam in terms of the chemical composition of the foam and/or in terms of a property of the foam including the cell count, measured in cells per inch, the apparent density measured according to DIN EN ISO 84, the compression load deflection measured according to ISO 3386-1, the elongation at break measured according to DIN 5357, wherein the wound dressing, as used in vacuum therapy, can be introduced into the wound with its first layer pointing towards the wound base or with its second layer pointing towards the wound base, depending on the choice made by the user.

摘要翻译： 本发明涉及一种用于伤口真空治疗的伤口敷料，包括由第一多孔泡沫构成的第一层，由第二多孔泡沫构成的第二层，其中第二层不可释放地连接到第一层 ，多个通孔通过两层通过相似的通道，其特征在于，就泡沫的化学组成和/或泡沫的性质而言，第一泡沫与第二泡沫不同，泡沫的性质包括 根据DIN EN ISO 84测量的细胞计数，以DIN EN ISO 84测量的表观密度，根据ISO 3386-1测量的压缩载荷挠度，根据DIN 5357测量的断裂伸长率，其中使用的伤口敷料 在真空治疗中，可以根据使用者的选择将其第一层指向伤口基部或其第二层指向伤口基底，从而引入伤口中。