公开(公告)号：EP1572902B1

公开(公告)日：2014-06-11

申请号：EP03708928.1

申请日：2003-01-31

申请人： Life Technologies Corporation

发明人： BROWN, David ,  FORD, Lance, P. ,  JARVIS, Rich ,  PALLOTTA, Vince ,  PASLOSKE, Brittan

IPC分类号： C12N15/11 ,  C12N15/113 ,  C12N5/10 ,  C12P19/34

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/53 ,  C12N2320/50 ,  C12Y102/01012

公开(公告)号：EP2688595A2

公开(公告)日：2014-01-29

申请号：EP12763967.2

申请日：2012-03-26

申请人： Children's Medical Center Corporation ,  Dana-Farber Cancer Institute, Inc.

发明人： GREGORY, Richard ,  PISKOUNOVA, Elena ,  ILIOPOULOS, Dimitrios

IPC分类号： A61K48/00 ,  A61K31/7105 ,  A61K31/7088 ,  A61P35/00

CPC分类号： C07K16/40 ,  A61K31/7105 ,  A61K31/713 ,  C07K2/00 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/115 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/50

摘要： The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis; for example Lin28-mediated biogenesis of let-7; and in particular Lin28A-recruited 3′ terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.

公开(公告)号：EP2046970B1

公开(公告)日：2014-01-08

申请号：EP07789931.8

申请日：2007-08-03

申请人： Dublin City University

发明人： GAMMELL, Patrick ,  BARRON, Niall ,  CLYNES, Martin

IPC分类号： C12P21/02 ,  C12N15/113 ,  C12N5/10

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/50

公开(公告)号：EP2164965B1

公开(公告)日：2013-09-11

申请号：EP08763141.2

申请日：2008-05-29

申请人： University Of The Witwatersrand, Johannesburg

发明人： PATRICK, Arbuthnot ,  ELY, Abdullah ,  NAIDOO, Tanusha ,  WEINBERG, Marc Saul ,  LONGSHAW, Victoria Mary

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/111 ,  C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/50

公开(公告)号：EP2547768A1

公开(公告)日：2013-01-23

申请号：EP11710168.3

申请日：2011-03-17

申请人： Association Institut de Myologie

发明人： GARCIA, Luis ,  FURLING, Denis ,  BELEY, Cyriaque ,  VOIT, Thomas

IPC分类号： C12N15/11 ,  A61K31/7088 ,  A61K48/00

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/531 ,  C12N2320/33 ,  C12N2320/34 ,  C12N2320/50 ,  C12N2330/51

摘要： The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified U7 snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.

公开(公告)号：EP1765074B1

公开(公告)日：2012-10-03

申请号：EP04754153.7

申请日：2004-06-03

申请人： Isis Pharmaceuticals, Inc.

发明人： BHAT, Balkrishen ,  SWAYZE, Eric ,  PRAKASH, Thazha, P. ,  ALLERSON, Charles ,  DANDE, Prasad ,  GRIFFEY, Richard, H.

IPC分类号： C07H21/04 ,  C12N15/11

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2320/50 ,  C12Y301/03048 ,  C12N2310/3525 ,  C12N2310/3521

公开(公告)号：EP1470148B1

公开(公告)日：2012-07-18

申请号：EP03708949.7

申请日：2003-02-03

申请人： Life Technologies Corporation

发明人： WOOLF, Tod, M. ,  WIEDERHOLT, Kristin, A.

IPC分类号： C12N15/00

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

摘要： The present invention relates to methods of preparing oligonucleotide compositions. In particular, the invention relates to a method of making an oligonucleotide composition comprising at least two different oligonucleotides targeted to two different sequences in a target gene.

公开(公告)号：EP1389637B1

公开(公告)日：2012-05-30

申请号：EP02017601.2

申请日：2002-08-05

申请人： Silence Therapeutics Aktiengesellschaft

发明人： Klippel, Anke ,  Kaufmann, Jörg ,  Giese, Klaus

IPC分类号： C12N15/113 ,  A61K31/713 ,  C07H21/02 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2310/317 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/53 ,  C12N2320/50 ,  C12N2320/51 ,  C12Y301/03048 ,  C12N2310/3525

公开(公告)号：EP2455467A1

公开(公告)日：2012-05-23

申请号：EP11169151.5

申请日：2003-02-03

申请人： Life Technologies Corporation

发明人： Woolf, Todd, M. ,  Wiederholt, Kristin A.

IPC分类号： C12N15/00 ,  A61K31/713 ,  C12N15/11

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

摘要： Antisense sequences, including duplex RNAi , which possess improved properties over those taught in the prior art are disclosed. The invention provides optimised antisense oligomer compositions and methods for the regulation of gene expression in a cell.

摘要翻译： 公开了反义序列，包括双链RNAi，其具有比现有技术中教导的性质改进的性质。 本发明提供了用于调节细胞中基因表达的优化的反义寡聚体组合物和方法。

公开(公告)号：EP2213292B1

公开(公告)日：2012-05-09

申请号：EP10152725.7

申请日：2003-02-03

申请人： Life Technologies Corporation

发明人： Woolf, Tod M. ,  Wiederholt, Kristin A.

IPC分类号： A61K31/713 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

摘要： The present invention relates to methods of preparing oligonucleotide compositions. In particular, the invention relates to a method of making an oligonucleotide composition comprising at least two different oligonucleotides targeted to two different sequences in a target gene.