公开(公告)号：EP1782806A1

公开(公告)日：2007-05-09

申请号：EP05292341.4

申请日：2005-11-04

申请人： Centre National de Genotypage

发明人： Fischer, Judith

IPC分类号： A61K31/202 ,  A61K38/16 ,  A61P17/00 ,  A61P25/00 ,  C07K16/18 ,  C12Q1/68 ,  C12N1/00 ,  C12N5/10 ,  C12N5/16 ,  C12N5/22 ,  G01N33/48

CPC分类号： A61K31/202 ,  A61K38/00 ,  C12N9/0071 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  C12Y114/13 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/20

摘要： The present application relates to compositions and the treatment of skin disorders, dry skin, protection of skin in inflammatory events and neurological disorders. The present application more particularly discloses the identification of new genes and metabolic pathways involved in skin disorders, which provide novel targets and approaches for treating said disorders and for screening biologically active compounds. The present invention also provides various products and constructs, such as probes, primers, vectors, recombinant cells, which can be used to implement the above methods. The invention may be used to detect or treat various skin disorders, particularly dry and inflammatory skin disorders and neurological disorders, in various subjects, including mammalian subjects, particularly human beings.

摘要翻译： 本申请涉及组合物和皮肤病症，干性皮肤的治疗，炎症事件中的皮肤保护和神经障碍。 本申请更具体地公开了鉴定涉及皮肤病症的新基因和代谢途径，其提供用于治疗所述病症和筛选生物活性化合物的新靶标和方法。 本发明还提供可用于实施上述方法的各种产物和构建体，例如探针，引物，载体，重组细胞。 本发明可用于检测或治疗各种受试者，包括哺乳动物受试者，特别是人类的各种皮肤疾病，特别是干性和炎性皮肤病症和神经障碍。

公开(公告)号：EP1373476A2

公开(公告)日：2004-01-02

申请号：EP02709797.1

申请日：2002-03-08

申请人： University of Kentucky Research Foundation

发明人： CHAPPELL, Joseph ,  RALSTON, Lyle, F.

IPC分类号： C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/29 ,  C12N15/70 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85

CPC分类号： C12N9/0073 ,  C12N9/0077 ,  C12N15/8243 ,  C12N15/8279 ,  C12P7/00 ,  C12P7/02 ,  C12Y114/13 ,  C12Y114/13078 ,  C12Y114/13119

摘要： The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.

摘要翻译： 本发明具有分离的细胞色素P450多肽和核酸分子以及含有这些分子的表达载体和转基因植物。 此外，本发明的特征在于这样的分子在增加对由转基因植物中的植物病原体引起的疾病的抗性水平的方法中的用途，生产改变的化合物的方法，例如羟化化合物，以及在产生类异戊二烯的方法中 化合物。