-
公开(公告)号：EP2880419A4
公开(公告)日：2016-03-30
申请号：EP13825268
申请日：2013-07-29
申请人： OWL BIOMEDICAL INC
发明人： FOSTER JOHN S , GRUMMITT DARYL W
CPC分类号： G01N15/1463 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0454 , B07C5/3425 , G01N15/1404 , G01N15/1425 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/1413 , G01N2015/149
摘要： A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.
摘要翻译： 一种使用粒子操纵级和多个激光询问区的基于MEMS的粒子操纵系统。 激光询问区域可用于评估粒子操纵阶段的有效性或准确性。 在一个示例性实施例中，颗粒操纵阶段是微制造的翼片型流体阀，其从流体流中的非目标颗粒中分选目标颗粒。 激光询问阶段在翼型分选阀的输入和输出处被布置在微细加工的流体通道中。 激光询问区域可用于评估排序的有效性或准确性，以及在排序过程中控制或调整排序参数。
-
22.发明公开OPERATORLESS PARTICLE PROCESSING SYSTEMS AND METHODS 审中-公开BEDIENERLOSE PARTIKELVERARBEITUNGSSYSTEME UND-FORFAHREN
公开(公告)号：EP2972206A2
公开(公告)日：2016-01-20
申请号：EP14720363.2
申请日：2014-03-13
申请人： Cytonome/ST, LLC
发明人： MORAD, Blair, D. , SHARPE, Johnathan, Charles , SEDOGLAVICH,Nemanya , SHAPIRO, Vladimir , EHRLICH, Stuart, R. , PERRAULT, Donald, Francis, Jr.
CPC分类号： G05D21/02 , G01N15/1404 , G01N15/1425 , G01N15/1484 , G01N2015/1006 , G01N2015/1406 , G01N2015/1452 , G01N2015/149
摘要： The present disclosure provides improved particle processing (e.g., cytometry and/or cell purification) systems and methods that can operate in an autonomous fashion. More particularly, the present disclosure provides for assemblies, systems and methods for analyzing, sorting, and/or processing (e.g., purifying, measuring, isolating, detecting and/or enriching) particles (e.g., cells, microscopic particles, etc.) where human intervention is not required and/or is minimized. The systems, assemblies and methods of the present disclosure advantageously improve run performance of particle processing systems (e.g., cell purification systems, cytometers) by significantly reducing and/or substantially eliminating the burden of operation for human intervention by automating numerous functions, features and/or steps of the disclosed systems and methods.
摘要翻译： 本公开提供可以以自主的方式操作的改进的颗粒处理（例如，细胞计数和/或细胞纯化）系统和方法。 更具体地，本公开提供了用于分析，分选和/或处理（例如，净化，测量，分离，检测和/或富集）颗粒（例如，细胞，微观颗粒等）的组件，系统和方法，其中 不需要人力干预和/或被最小化。 本公开的系统，组件和方法有利地通过自动化许多功能，特征和/或功能来显着地减少和/或基本上消除人为干预的操作负担来改善颗粒处理系统（例如细胞纯化系统，细胞计数器）的运行性能， 或所公开的系统和方法的步骤。
-
23.发明公开A sample analyzer, and a method for analyzing a sample 审中-公开Probenanalysator和Verfahren zur Probenanalyse
公开(公告)号：EP2169382A2
公开(公告)日：2010-03-31
申请号：EP09171585.4
申请日：2009-09-29
申请人： SYSMEX CORPORATION
发明人： Kusuzawa, Hideo
IPC分类号： G01N15/14
CPC分类号： G01N15/1434 , G01N15/1425 , G01N15/147 , G01N2015/1497
摘要： A sample analyzer comprising a flow cell for forming a sample flow, a light source for irradiating the sample flow in the flow cell with near ultraviolet flight, and an imaging section for taking an image of a particle contained in the sample flow irradiated with the near ultraviolet light by the light source is disclosed.
A method for analyzing a sample is also disclosed.摘要翻译： 一种样品分析器，包括用于形成样品流的流动池，用于在近紫外线飞行下照射流动池中的样品流的光源和用于拍摄被照射的样品流中包含的颗粒的图像的成像部分 公开了通过光源的紫外光。 还公开了一种用于分析样品的方法。
-
公开(公告)号：EP1579374A1
公开(公告)日：2005-09-28
申请号：EP03810789.2
申请日：2003-10-20
IPC分类号： G06K9/00
CPC分类号： G01N15/1425 , G01N15/1459 , G01N15/1463 , G01N2015/1406 , G01N2015/149 , Y10T436/115831
摘要： Methods, systems and apparatus are provided for sorting particles in a stream of a sample in a flow cytometer by producing from a stable sort having desirable sort characteristics multiple images of a portion of the stream; generating from the multiple images an averaged numerical reference standard representative of the stable sort; continuously collecting during the sorting multiple running images of the portion of the stream; generating from the multiple running images at least one numerical sample average representative of the sample sort of each collection of the multiple running images; and comparing each numerical sample average to the numerical reference standard and determining whether a sample average exhibits a deviation from the reference standard that requires an adjustment of the sort. The sort may then be adjusted to eliminate or reduce the deviation and maintain the stable sort of the reference histogram. A novel imaging apparatus may be employed in a flow cytometer performing this method.
-
公开(公告)号：EP1424548A1
公开(公告)日：2004-06-02
申请号：EP03021809.3
申请日：2003-09-26
申请人： Evotec OAI AG
IPC分类号： G01N15/14
CPC分类号： G01N15/1425 , G01N15/1427 , G01N15/1434 , G01N2015/144 , G02B21/0044 , G02B21/0076
摘要： Gemäß des erfindungsgemäßen Verfahrens wird ein von der Bestrahlungseinrichtung (14) abgegebener Strahlungspuls (16) zur Bestrahlung einer zu untersuchenden Probe (22) genutzt. Die Strahlungspulse werden beispielsweise an einer Nipkow-Scheibe (20), die Bestandteil einer Optikeinrichtung (18,20,28) ist, gestreut und gelangen über einen Strahlteiler (38), wie durch die Pfeile (42) dargestellt, zu einer Detektionseinrichtung (30). Zeitlich versetzt hierzu gelangen von in der Probe (22) vorhandenen Partikeln gestreute oder reflektierte Strahlungspulse, wie durch die Pfeile (40,44) dargestellt ist, ebenfalls zur Detektionseinrichtung (30). Auf Grund des zeitlichen Versatzes zwischen diesen an der Detektionseinrichtung (30) ankommenden Streulichtpulsen kann das von in der Probe (22) vorhandenen Partikeln kommende Streulicht festgestellt und zur Bestimmung beispielsweise der Größe und der Form von in der Probe (22) enthaltenen Partikeln genutzt werden.
摘要翻译： 在光束路径中使用光学单元（18,20,28）用电磁脉冲（16）照射样品（22）。 检测由颗粒辐射的脉冲（40,44）（30）。 照射脉冲频率和检测间隔是协调的，使得可以区分入射脉冲和返回的脉冲。 包含微观粒子检测系统的独立权利要求
-
26.发明公开METHOD OF CONTROLLING THE FLOW IN A FLOW SYSTEM 审中-公开VERFAHREN ZUR STEUERUNG DES DURCHFLUSSES IN EINEM FLUSSYSTEM
公开(公告)号：EP1257803A1
公开(公告)日：2002-11-20
申请号：EP01903613.6
申请日：2001-02-13
CPC分类号： G01N15/1425 , G01N15/1056 , G01N15/14 , G01N15/1484 , G01N30/6095 , G01N2015/1081 , G01N2015/1413 , G01N2015/149 , G01N2030/326 , G01N2030/383 , Y10T137/0391 , Y10T137/0396 , Y10T137/2082 , Y10T137/2191 , Y10T137/2229 , Y10T137/86163
摘要： With a method of controlling the flow in a flow system where a liquid flow contains a particle concentration, the liquid flow is surrounded by a carrier liquid. The liquid flow and carrier liquid are led into a central channel in which there is provided an observation area (4) where measurements of the liquid flow are effected. The result of the measurements are used to lead the liquid flow into one of several channels, in that control liquids are introduced into the liquid flow before this reaches the channels, the control liquids being derived from a capillary pump structure which pumps on the basis of an electro-kinetic effect, e.g. an electro-osmotic effect. In a preferred embodiment, the pump structure consists of two capillary structures, to each of which an electrical field can be applied. Depending on the strength of the field, the amount of control liquid will be able to be controlled so that the liquid flow with the particle concentration can be led to one of two channels. In a second embodiment, the pump structure consists of one capillary structure. The liquids can with advantage be controlled in such a manner that when the amount of liquid in the one capillary structure is increased, the amount of liquid in the second capillary structure will thus be reduced correspondingly. The advantage of the invention is first and foremost that the pumping is carried out without the use of mechanical pumping arrangements, which are relatively expensive. Moreover, a better retention of the flow pattern in the flow system is achieved.
摘要翻译： 通过控制液体流中含有颗粒浓度的流动系统中的流动的方法，液体流被载体液体包围。 液体流和载体液体被引入中心通道，其中设置有观察区域（4），其中进行液体流量的测量。 测量结果用于将液体流引导到几个通道中的一个，因为控制液体在到达通道之前被引入液体流中，控制液体来源于基于 电动效应，例如 电渗效应。 在优选实施例中，泵结构由两个毛细管结构组成，其中每个可以施加电场。 根据场强的不同，可以控制控制液的量，从而将粒子浓度的液体流量引导到两个通道之一。 在第二实施例中，泵结构由一个毛细管结构组成。 有利地可以以这样的方式控制液体，即当一个毛细结构中的液体量增加时，第二毛细管结构中的液体量因此将相应地降低。 本发明的优点首先在于不使用相对昂贵的机械泵送装置来进行泵送。 此外，实现了在流动系统中更好地保持流动模式。
-
27.发明公开Automatic focal-point adjustment method in flow imaging cytometer 失效维也纳自动化公司Brennpunktregelung在einem“Strömungsabbildungscytometer”。
公开(公告)号：EP0468100A1
公开(公告)日：1992-01-29
申请号：EP90125596.8
申请日：1990-12-27
发明人： Kosaka, Tokihiro
CPC分类号： G01N15/1425 , G01N15/1012 , G01N2015/1409 , G01N2015/144 , G01N2015/1452
摘要： A flow imaging cytometer for imaging the dimensions and shapes of particle components in a flow of a specimen solution employs a separate control solution, which is for managing precision, containing standard particles. A method of adjusting focal point with respect to the specimen flow includes steps of imaging the standard particles in the control solution, calculating an evaluation parameter which represents the definition of the image, and moving the flow cell or associated optical system so as to maximize the value of this parameter.
摘要翻译： 用于对样品溶液流中的颗粒组分的尺寸和形状进行成像的流动成像细胞仪采用单独的控制溶液，其用于管理含有标准颗粒的精度。 相对于样本流调节焦点的方法包括在控制溶液中成像标准颗粒的步骤，计算表示图像定义的评估参数，以及移动流动池或相关联的光学系统，以使 该参数的值。
-
28.发明公开
公开(公告)号：EP4433802A1
公开(公告)日：2024-09-25
申请号：EP22896347.6
申请日：2022-11-10
CPC分类号： G01N2015/100620130101 , G01N15/1429 , G01N15/1425 , G01N15/147 , G01N15/1433 , G01N15/149
-
公开(公告)号：EP4420149A1
公开(公告)日：2024-08-28
申请号：EP22884468.4
申请日：2022-10-20
申请人： Zeteo Tech, Inc.
-
公开(公告)号：EP4406001A1
公开(公告)日：2024-07-31
申请号：EP22873401.8
申请日：2022-08-29
发明人： SOUCHKOV, Vitali
CPC分类号： G01N15/1429 , G01N15/1425 , G01N15/1459 , G01N2015/100620130101 , H03F3/45475 , H03F2200/26120130101 , H03F3/087 , G01N15/149
-
-
-
-
-
-
-
-
-
搜索结果
80 条记录 (耗时 0.017 秒)
