公开(公告)号：EP2880419A4

公开(公告)日：2016-03-30

申请号：EP13825268

申请日：2013-07-29

申请人： OWL BIOMEDICAL INC

发明人： FOSTER JOHN S ,  GRUMMITT DARYL W

IPC分类号： G01N15/14 ,  B01L3/00 ,  G01N15/10

CPC分类号： G01N15/1463 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0454 ,  B07C5/3425 ,  G01N15/1404 ,  G01N15/1425 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1081 ,  G01N2015/1413 ,  G01N2015/149

摘要： A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.

摘要翻译： 一种使用粒子操纵级和多个激光询问区的基于MEMS的粒子操纵系统。 激光询问区域可用于评估粒子操纵阶段的有效性或准确性。 在一个示例性实施例中，颗粒操纵阶段是微制造的翼片型流体阀，其从流体流中的非目标颗粒中分选目标颗粒。 激光询问阶段在翼型分选阀的输入和输出处被布置在微细加工的流体通道中。 激光询问区域可用于评估排序的有效性或准确性，以及在排序过程中控制或调整排序参数。

公开(公告)号：EP2731576A4

公开(公告)日：2015-04-29

申请号：EP12866437

申请日：2012-07-11

申请人： OWL BIOMEDICAL INC ,  INNOVATIVE MICRO TECHNOLOGY

发明人： FOSTER JOHN S ,  GRUMMITT DARYL W ,  HARLEY JOHN C ,  LINTON JAMES P ,  SPONG JAQUELIN K

IPC分类号： A61J1/06 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N15/14

CPC分类号： C12M47/04 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/0439 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N15/1459 ,  G01N2015/149

摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.