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公开(公告)号：EP0571202A1
公开(公告)日：1993-11-24
申请号：EP93303895.2
申请日：1993-05-19
发明人： Misner, Jerry Wayne
IPC分类号： C07D457/02 , A61K31/48
CPC分类号： C07D457/02
摘要： Pergolide is produced from 8,9-dihydroelymoclavine by a one-pot process in which it is reacted successively with 1-iodopropane, with a sulfonyl halide, and with an alkali metal thiomethoxide without isolation of intermediate products.
摘要翻译： 通过一锅方法由8,9-二氢麦芽酮糖苷生产高尔胶精，其中其与1-碘丙烷，磺酰卤，和不分离中间产物的碱金属甲醇化物相继反应。
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22.发明授权Ergoline esters, a process for their preparation and pharmaceutical compositions containing them 失效ERGOLINE ESTERS，其制备和含有它们的药物组合物的方法
公开(公告)号：EP0249761B1
公开(公告)日：1992-11-11
申请号：EP87107280.7
申请日：1987-05-19
IPC分类号： C07D457/02 , A61K31/48
CPC分类号： C07D457/02
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23.发明公开
公开(公告)号：EP0483077A3
公开(公告)日：1992-09-23
申请号：EP91830402.3
申请日：1991-09-27
发明人： Fraschini, Franco, I.F.L.O. S.a.s. , Duranti, Ermanno, I.F.L.O. S.a.s. , Di Bella, Luigi, I.F.L.O. S.a.s. , Stankov, Bojidar, I.F.L.O. S.a.s. , Laguzzi, Aldo, I.F.L.O. S.a.s.
IPC分类号： A61K31/565 , A61K31/57 , C07D209/30 , C07D457/02
CPC分类号： A61K31/40 , A61K31/565 , A61K31/57 , Y10S514/843 , A61K31/405 , A61K2300/00
摘要： The present invention relates to a drug for human use, having contraceptive and menstrual cycle controlling properties, characterized in that the said drug comprises N-acetyl-5-methoxytryptamine or melatonin, in a dose of 100-200 mg pro die, N-acetyl-2-bromo-5-methoxytryptamine or 2-bromomelatonin in a dose of 25-50 mg pro die N-acetyl-2-iodo-5-methoxytryptamine or 2-iodomelatonin, in a dose of 20-40 mg pro die, in association with a progestinic compound. The administration is carried out for 23 days, by using an association of 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin and a progestinic compound, followed by 5 days in which only 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin is administered; the drug having oncostatic preventive and therapeutic properties, in mammary tumours and melanomas, characterized by the use of 2-iodomelatonin, melatonin and 2-bromomelatonin respectively with doses of 20-40 mg, 100-200 mg, 25-50 mg pro die; and the said drug having moreover antikinetosic properties, and being characterized by the use of 2-iodomelatonin in a dose pro die of 2.5 mg, melatonin, in a dose pro die of 10 mg and 2-bromomelatonin in a dose pro die of 3.5 mg, either individually and/or in association with the acetyl coenzime A-(AcCoA), in a dose of 8-10 mg pro die.
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24.发明公开Ergoline derivatives of proline and related compounds having dopaminergic activity 失效具有多巴胺活性的丙泊酚及相关化合物的胆固醇衍生物
公开(公告)号：EP0411495A3
公开(公告)日：1991-10-23
申请号：EP90114445.1
申请日：1990-07-27
发明人： Poli, Stefano , Coppi, Germano , del Corona, Lucio
IPC分类号： C07D457/08 , C07D457/02 , A61K31/435
CPC分类号： C07D457/02 , C07D457/08
摘要： Ergoline derivatives containing the L-proline moiety and some derivatives thereof having dopaminergic activity, the processes for the preparation thereof and pharmaceutical compositions containing them.
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公开(公告)号：EP0209456B1
公开(公告)日：1991-01-16
申请号：EP86401539.1
申请日：1986-07-10
申请人： RHONE-POULENC SANTE
发明人： Gervais, Christian
IPC分类号： C07D457/02
CPC分类号： C07D457/02
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26.发明授权Piperazin-1-yl-ergoline derivatives, process for preparing them and pharmaceutical compositions containing them 失效哌嗪-1-基-L-胆固醇衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：EP0197241B1
公开(公告)日：1989-12-27
申请号：EP86100391.1
申请日：1986-01-14
发明人： Mantegani, Sergio , Temperilli, Aldemio , Traquandi, Gabriella , Rossi, Alessandro , Pegrassi, Lorenzo
IPC分类号： C07D457/02 , A61K31/48
CPC分类号： C07D457/02
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27.发明授权Process for the preparation of N1-methyl-10alpha-methoxylumilysergol and esters thereof, and intermediates for their preparation 失效制备N1-METHYL-10ALPHA-甲氧基硅烷的方法及其制备方法及其制备中间体
公开(公告)号：EP0156645B1
公开(公告)日：1989-11-02
申请号：EP85302101.2
申请日：1985-03-26
IPC分类号： C07D457/02
CPC分类号： C07D457/02
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28.发明公开Ergoline esters, a process for their preparation and pharmaceutical compositions containing them 失效葡萄糖苷，其制备方法及含有它们的药物组合物
公开(公告)号：EP0249761A3
公开(公告)日：1989-05-10
申请号：EP87107280.7
申请日：1987-05-19
IPC分类号： C07D457/02 , A61K31/48
CPC分类号： C07D457/02
摘要： Ergoline Esters I
(R₁=H or CH₃; R₂=C₁-C₄ hydrocarbon; R₃=H or OCH₃; R₄=H or halogen; R₅=C₁-C₄ alkyl) and their pharmaceutically acceptable salts are active in the central nervous system level. A process for their preparation is also described. The ergoline esters and their salts can be used for the making of pharmaceutical compositions being effective against cerebral insufficiency and senile dementia.-
公开(公告)号：EP0251652A3
公开(公告)日：1989-04-05
申请号：EP87305570.1
申请日：1987-06-23
IPC分类号： C07D457/02 , A61K31/48
CPC分类号： C07D457/02
摘要： Ergoline derivatives of general formula I
wherein either R₁ represents a hydrogen atom or a methoxy group and R₂ represents a hydrogen atom or R₁ and R₂ taken together represent a chemical bond, and R₃ represents a hydrogen atom, an unsubstituted or substituted nicotinoyl group or a 1-oxo-2-cyclopenten-3-yl group; or a pharmaceutically acceptable salt thereof are active at the Central Nervous System level and useful therefore in the treatment of cerebral insufficiency and senile dementia.-
30.发明授权Ergoline derivatives, processes for their preparation and pharmaceutical compositions containing same 失效ERGOLINE衍生物，其制备方法及含有其的药物组合物
公开(公告)号：EP0126968B1
公开(公告)日：1988-12-21
申请号：EP84104568.5
申请日：1984-04-24
发明人： Bernardi, Luigi , Chiodini, Laura , Mantegani, Sergio , Ruggieri, Daniela , Temperilli, Aldemio , Salvati, Patricia
IPC分类号： C07D457/00 , C07D457/12 , C07D457/02 , A61K31/48
CPC分类号： C07D457/02 , C07D457/12
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