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    Method for screening a lung transplant candidate for an elevated risk of rejection
    31.
    发明公开
    Method for screening a lung transplant candidate for an elevated risk of rejection 审中-公开
    筛选肺移植候选人拒绝的风险增高方法

    公开(公告)号：EP2672266A3

    公开(公告)日：2014-02-05

    申请号：EP13175642.1

    申请日：2007-01-13

    申请人： Indiana University Research&Technology Corporation ,  Wilkes, David S. ,  Klemsz, Michael J.

    发明人： Wilkes, David S. ,  Klemsz, Michael J.

    IPC分类号： G01N33/00 ,  G01N33/566 ,  G01N33/567 ,  G01N33/564 ,  G01N33/68

    CPC分类号： G01N33/564 ,  G01N33/6887 ,  G01N2800/12

    摘要： Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary Fibrosis (IPF) are diagnosed by analyzing fluid or tissue samples obtained from a patient for evidence of an autoimmune response to various types of collagen including, for example, Type V. One type of assay for evidence of an autoimmune response to Type V collagen comprises the steps of obtaining a fluid or tissue sample from a patient, contacting at least a portion of the sample with antigen to anti-Type V collagen antibody and monitoring the mixture of sample and antigen for changes indicative of the presence of anti-Type V collagen in the sample. Another embodiment includes treating pulmonary diseases such as IPF by administering a therapeutically effective dose of epitopes of various collagens including Type V collagen.

    MATERIALS AND METHODS FOR IDENTIFYING AND USING YEAST STRAINS THAT METABOLIZE PENTOSE SUGARS IN THE PRESENCE OF D-GLUCOSE
    32.
    发明公开
    MATERIALS AND METHODS FOR IDENTIFYING AND USING YEAST STRAINS THAT METABOLIZE PENTOSE SUGARS IN THE PRESENCE OF D-GLUCOSE 审中-公开
    材料和用于识别并使用D-GLUCOSE PENTOSEMETABOLISIERENDEN酵母菌株的存在的方法

    公开(公告)号：EP2401358A1

    公开(公告)日：2012-01-04

    申请号：EP10746850.6

    申请日：2010-02-25

    申请人： Indiana University Research&technology Corporation ,  Goebl, Mark ,  Woods, Cary ,  Cocklin, Ross ,  Heyen, Josh

    发明人： GOEBL, Mark ,  WOODS, Cary ,  COCKLIN, Ross ,  HEYEN, Josh

    IPC分类号： C12N1/00

    CPC分类号： C12N1/18 ,  C12N15/01 ,  C12P7/00 ,  C12P7/06 ,  Y02E50/16 ,  Y02E50/17

    摘要： Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and/or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.

    摘要翻译： 公开用于创建和/或分离的酵母的变种爱尤其酿酒酵母的变种也可在2-脱氧葡萄糖和或D-葡萄糖的量的存在比D-葡萄糖等糖类生长的材料和方法做了抑制大多数菌株 从在除D-葡萄糖其它糖生长酵母。 选择培养基做可用于隔离检测的变体包括戊糖：诸如D-木糖，L-谷氨酰胺和2-脱氧葡萄糖。 因此在基因GRR1和Red在某些菌株中的突变产生的变体确实可在糖生长包含在2-脱氧葡萄糖存在下的戊糖D-木糖。