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公开(公告)号：EP1517997A2
公开(公告)日：2005-03-30
申请号：EP03729139.0
申请日：2003-05-23
发明人： DIWU, Zhenjun , LIAO, Jinfang , WANG, Zhiqiang
CPC分类号： C07K5/021 , C07D311/82 , C07D493/10 , C07K7/02 , C12Q1/37
摘要： Systems, including compositions, kits, and methods, suitable for performing enzyme assays, such as protease assays. The composition may include derivatives of rhodamine 110 that are substitued at the xanthylium nitrogens by a peptide moiety and a morpholine-4-carbonyl moiety, respectively. These compositions may be luminogenic substrates for a large variety of protease enzymes, with utility in a variety of sensitive protease enzyme assays.
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公开(公告)号：EP0510725B1
公开(公告)日：1997-04-09
申请号：EP92109904.0
申请日：1987-06-19
发明人： Parce, John W. , Zuk, Robert F.
IPC分类号： G01N27/403 , G01N27/414
CPC分类号： G01N27/3271 , G01N27/327 , Y10S435/817 , Y10S436/806
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公开(公告)号：EP0620845A1
公开(公告)日：1994-10-26
申请号：EP91911165.0
申请日：1991-06-04
发明人： HUMPHRIES, Gillian, M., K. , MILLER, Donald, Lee , LIBBY, Jeffrey, M. , SCHWARTZ, Henry, Lee , PARCE, John, Wallace , WADA, Henry, Garrett , KIRK, Gregory, L.
CPC分类号： C12M25/04 , Y10S435/817
摘要： Cette invention se rapporte à des microcompartiments poreux qui contiennent des cellules et permettent à un liquide de s'écouler dans et hors du compartiment tout en retenant les cellules à l'intérieur du compartiment. Ces microcompartiments poreux agissent comme des dispositifs jetables grâce auxquels l'on peut placer les cellules dans un microcompartiment d'écoulement de sorte que les caractéristiques des cellules contenues dans les microcompartiment poreux peuvent être mesurées.
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公开(公告)号：EP0255223B1
公开(公告)日：1993-10-13
申请号：EP87305456.3
申请日：1987-06-19
发明人： Parce, John W. , Zuk, Robert F.
CPC分类号： G01N27/3271 , G01N27/327 , Y10S435/817 , Y10S436/806
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公开(公告)号：EP0510725A2
公开(公告)日：1992-10-28
申请号：EP92109904.0
申请日：1987-06-19
发明人： Parce, John W. , Zuk, Robert F.
IPC分类号： G01N27/403 , G01N27/414
CPC分类号： G01N27/3271 , G01N27/327 , Y10S435/817 , Y10S436/806
摘要： Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode in the presence of a relatively large volume of an assay medium. The determinable element is present in the concentrate in the amount related to the amount of analyte present in the sample. The volume of the medium in diffusive communication with the concentrate is then reduced and the determinable element is detected by means of the effect that the determinable element has on the semiconductive electrode.
摘要翻译： 描述了用于确定疑似含有分析物的样品中分析物的存在的方法和装置。 该方法包括在相对较大体积的测定介质的存在下使能够通过半导体电极检测的可测定元件的浓缩物与电极接触。 浓缩物中可测定的元素以与样品中存在的分析物的量相关的量存在。 然后减少与浓缩物扩散连通的介质的体积，并且通过可确定元件在半导体电极上具有的效果来检测可确定元件。
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公开(公告)号：EP0310251A3
公开(公告)日：1989-07-26
申请号：EP88308164.8
申请日：1988-09-02
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6804 , C12Q1/6834 , Y10T436/143333 , C12Q2522/101
摘要： Picogram amounts of DNA can be detected in a sample by the use of high-affinity, single-stranded DNA binding proteins. The assay is applicable not only to pure DNA samples but also to samples containing significant amounts of protein.
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公开(公告)号：EP0290125A3
公开(公告)日：1989-05-31
申请号：EP88302475.4
申请日：1988-03-22
CPC分类号： B01L3/5085 , B29C59/14 , G01N21/03 , G01N2201/0446
摘要： A microtiter plate prepared from a hydrophobic plastic is rendered more hydrophilic by treatment of the surfaces of the wells of the microplate prior to use. The resulting plates are particularly useful in vertical beam photometry.
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公开(公告)号：EP0213825A3
公开(公告)日：1989-04-26
申请号：EP86306176.8
申请日：1986-08-11
CPC分类号： G01N27/227 , G01N33/5438
摘要： Apparatus and methods are provided for multiple detection of analytes employing semiconductor capacitance as the signal modulated by the analyte. A plurality of semiconductor capacitors (20) are organized for detection (at individual sites) of changes in capacitance which are related to changes in a fluid medium, where the change can be related to the presence of an analyte in a channel (16) between the capacitors and a plate (14). Specific bonding compounds (24) may be placed adjacent some or all of the capacitors on a surface coating (22).
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公开(公告)号：EP0166108A3
公开(公告)日：1987-06-24
申请号：EP85104846
申请日：1985-04-22
CPC分类号： G01N33/5438 , C12Q1/004 , G01N27/305 , Y10S435/966 , Y10S435/973 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
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40.发明公开Apparatus and method for optical assay imaging 失效Verfahren und Vorrichtung zur Abbildung von optischnachprüfbarenReaktionsversuchen。
公开(公告)号：EP0217619A2
公开(公告)日：1987-04-08
申请号：EP86307299.7
申请日：1986-09-23
CPC分类号： G01N21/272 , G01N21/253 , G01N21/6428 , G01N2201/0461
摘要： Apparatus and methods for optically assaying an analyte borne on a support use a light source (24) to irradiate a sample of analyte (26), a light from which is received by a group of memory cells in a dynamic RAM (28) over a given exposure time. The exposure may be repeated over different exposure times. The characteristic of the analyte to be determined is assayed by measurement of the states of the memory cells after such exposure(s).
摘要翻译： 用于光学测定载体上载体的分析物的装置和方法使用光源（24）来照射被分析物样品（26），该分析物的样品被动态RAM（28）中的一组存储器单元接收， 给定曝光时间。 可能会在不同的曝光时间重复曝光。 待测定的分析物的特征是通过测量这种暴露后的记忆细胞的状态来测定的。
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