公开(公告)号：EP1848813A4

公开(公告)日：2008-07-09

申请号：EP06733921

申请日：2006-01-26

申请人： UNIV BRIGHAM YOUNG ,  SCRIPPS RESEARCH INST ,  UNIV CHICAGO

发明人： TEYTON LUC ,  BENDELAC ALBERT ,  SAVAGE PAUL

IPC分类号： C12Q1/00 ,  C12N5/00 ,  C12N5/02 ,  C12N13/00 ,  G01N33/567

CPC分类号： A61K39/39 ,  A61K31/7032 ,  A61K35/74 ,  A61K38/1774 ,  A61K2039/55594

摘要： Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.

公开(公告)号：EP1651941A4

公开(公告)日：2008-03-26

申请号：EP04777177

申请日：2004-06-28

申请人： UNIV BRIGHAM YOUNG

发明人： LEE EDGAR D ,  ROCKWOOD ALAN L ,  WAITE RANDALL ,  LAMMERT STEPHEN A ,  LEE MILTON L

IPC分类号： H01J49/00 ,  B01D59/44 ,  G01N20060101 ,  H01J49/38 ,  H01J49/42

CPC分类号： A41C5/005 ,  H01J49/4295

摘要： A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be disposed on the two opposing surfaces using plating techniques that enable much higher tolerances to be met than existing machining techniques.

摘要翻译： 一种虚拟离子阱，其使用电聚焦场而不是通常围绕捕获体积的加工的金属电极，其中两个相对的表面包括多个独特设计和涂覆的电极，并且其中电极可以使用电镀技术设置在两个相对的表面上 这使得现有的加工技术能够实现更高的公差。

公开(公告)号：EP1569636A4

公开(公告)日：2007-07-04

申请号：EP03777994

申请日：2003-10-29

申请人： UNIV COLORADO STATE RES FOUND ,  UNIV BRIGHAM YOUNG ,  CHILDRENS HOSP MEDICAL CENTER

发明人： LEPHART EDWIN DOUGLAS ,  LUND TRENT D ,  SETCHELL KENNETH DAVID REGINAL ,  HANDA ROBERT J

IPC分类号： A61K31/35 ,  A61K20060101 ,  A61P5/28 ,  A61P25/22

CPC分类号： A61K31/353 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/0053 ,  A61K31/35 ,  A61K31/352 ,  A61Q7/00 ,  A61Q19/08

摘要： Equol (7-hydroxy-3(4'hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5alpha-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.

公开(公告)号：EP1463806A4

公开(公告)日：2006-07-05

申请号：EP02778399

申请日：2002-09-28

申请人： UNIV BRIGHAM YOUNG

发明人： SIMMONS DANIEL ,  CHANDRASEKHARAN VISHVANATH N

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K16/40 ,  C12M1/00 ,  C12M1/34 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12N9/0083

公开(公告)号：EP1322249A4

公开(公告)日：2006-05-17

申请号：EP01968091

申请日：2001-08-23

申请人： UNIV BRIGHAM YOUNG

发明人： TODD ROBERT ,  HANSEN SCOTT

IPC分类号： B26F3/00 ,  A61C1/00 ,  A61C3/02 ,  A61C3/025 ,  A61C5/02 ,  A61C3/00

CPC分类号： A61C3/025 ,  A61C1/00

摘要： An apparatus and method are disclosed for boring into teeth to remove decaying tool matter using a high pressure jet of water. A system according to the invention may include a pressurized water source operably connected to an applicator used to target the water stream at the decayed portion of the tooth. The invention contemplates water streams utilizing single or multiple stream orifices, pure water or particle-entrained streams, and constant high pressure or pulsing pressure to accomplish removal of oral material, including enamel.

公开(公告)号：EP1144432A4

公开(公告)日：2002-07-31

申请号：EP00905672

申请日：2000-01-19

申请人： UNIV BRIGHAM YOUNG

发明人： SAVAGE PAUL B ,  LI CHUNHONG

IPC分类号： A61K31/575 ,  A61K31/56 ,  A61P31/04 ,  C07J9/00 ,  C07J41/00

CPC分类号： C07J41/0055 ,  C07J9/00 ,  C07J9/005 ,  C07J31/003 ,  C07J41/0094

公开(公告)号：EP0796046A4

公开(公告)日：1998-04-15

申请号：EP95943061

申请日：1995-12-11

申请人： UNIV BRIGHAM YOUNG

发明人： OGDEN LYNN V

IPC分类号： A23C9/00 ,  A23C9/123 ,  A23C9/13 ,  A23C23/00 ,  A23G9/06 ,  A23G9/20 ,  A23G9/32 ,  A23G9/44 ,  A23G9/46 ,  A23G9/52 ,  A23L1/00 ,  A23L1/0562 ,  A23L1/06 ,  A23L1/187 ,  A23L3/3418 ,  A23P1/16

CPC分类号： A23G9/46 ,  A23C9/1307 ,  A23C2240/20 ,  A23G9/20 ,  A23L9/12 ,  A23L21/10 ,  A23L29/284 ,  A23P30/40

摘要： A process to add carbon dioxide under low shear conditions to an already formed food to produce a semi-solid or solid carbonated food. The carbonated semi-solid or solid spoonable food has the following properties: (a) a viscosity of between about 2000 and 200,000 centipoise at between about 1.5 DEG and 25 DEG C., and (b) a carbonation level of between about 0.5 and 4.0 volumes of carbon dioxide per volume of food. The process includes contacting the formed food with carbon dioxide gas with low shear agitation.

摘要翻译： 在低剪切条件下将二氧化碳添加到已经形成的食物以产生半固体或固体碳酸食品的方法。 碳酸化半固体或固体可舀取食品具有以下性质：（a）在约1.5至25℃之间的粘度为约2000至200,000厘泊，和（b）碳酸化水平为约0.5至4.0 每体积二氧化碳的数量。 该方法包括使形成的食物与二氧化碳气体在低剪切搅拌下接触。

公开(公告)号：EP3288560A4

公开(公告)日：2018-07-25

申请号：EP16783980

申请日：2016-04-22

申请人： UNIV BRIGHAM YOUNG

发明人： SAVAGE PAUL B ,  RANDALL JARED LYNN

IPC分类号： C07J41/00 ,  C07J9/00

CPC分类号： C07J75/00 ,  C07J9/005 ,  C07J41/0055 ,  C07J41/0061 ,  C07J41/0066 ,  C07J41/0088 ,  C07J41/0094

摘要： Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.

公开(公告)号：EP3285875A1

公开(公告)日：2018-02-28

申请号：EP16783976

申请日：2016-04-22

申请人： UNIV BRIGHAM YOUNG

发明人： SAVAGE PAUL B ,  JACKS THOMAS ELLIOT ,  MILLER ROSS ALLEN ,  THOMPSON ANDREW STEVEN ,  RANDALL JARED LYNN

IPC分类号： A61P31/22 ,  A61K39/42 ,  C12Q1/70

CPC分类号： C07J41/0088 ,  C07J9/005 ,  C07J41/0055 ,  C07J41/0061

摘要： Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.

公开(公告)号：EP3142765A4

公开(公告)日：2018-01-17

申请号：EP15793306

申请日：2015-05-15

申请人： UNIV BRIGHAM YOUNG

发明人： FARNSWORTH PAUL B ,  SHARMA SONIKA ,  TOLLEY H DENNIS ,  LEE MILTON L

IPC分类号： G01N30/74 ,  G01N21/03 ,  G01N21/33

CPC分类号： G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N2021/0346 ,  G01N2201/0221 ,  G01N2201/0621 ,  G01N2201/0693

摘要： A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.