公开(公告)号：EP0752991A1

公开(公告)日：1997-01-15

申请号：EP95914403.0

申请日：1995-03-23

申请人： RHONE-POULENC RORER S.A.

发明人： ALOUP, Jean-Claude ,  AUDIAU, François ,  BARREAU, Michel ,  DAMOUR, Dominique ,  GENEVOIS-BORELLA, Arielle ,  JIMONET, Patrick ,  MIGNANI, Serge ,  RIBEILL, Yves

IPC分类号： A61K31 ,  A61P1 ,  A61P3 ,  A61P9 ,  A61P25 ,  A61P29 ,  A61P31 ,  A61P37 ,  A61P39 ,  C07D405 ,  C07D409 ,  C07D487 ,  C07D491 ,  C07D495

CPC分类号： C07D487/04

摘要： Compounds of formula (I), wherein R is a substituted nitrogen, oxygen or sulphur atom or a radical C=R3, C(R4)R5 or CH-R6; R1 is a hydroxy radical, polyfluoroalkoxy, carboxy, alkoxycarbonyl, -NH-CHO or -NH-CO-N(alk)Ar where Ar is optionally substituted, -N(alk)-CO-NR8R9, -N(alk-Ar)-CO-NR8R9, -NH-CO-NR9R12, -NH-CS-NR8R9, -N(alk)-CS-NR8R9, -NH-CO-R10, -NH-CS-R20, -NH-C(=NR21)-NR7R9, -N(alk)-C(=NR21)-NR7R9, -NH-SO2-NR7R9, -N(alk)-SO2-NR7R9, -CO-NR7R9, -NH-SO2-CF3, -NH-SO2-alk, -NR9R11, -S(O)m-alk-Ar, -SO2-NR7R9, optionally 3-substituted 2-oxo-1-imidazolidinyl or optionally 3-substituted 2-oxo-1 perhydropyrimidinyl; R2 is a hydrogen or halogen atom or an akyl radical, alkoxy, amino, -NH-CO-NH-Ar, N=CH-N(alk)alk', nitro, cyano, phenyl, imidazolyl, acylamino, SO3H, hydroxy, polyfluoroalkoxy, carboxy, alkoxycarbonyl, -NH-CHO, -NH-CO-N(alk)Ar where Ar is optionally substituted, -N(alk)-CO-NR8R9, -N(alk-Ar)-CO-NR8R9, -NH-CO-NR9R12, -NH-CS-NR8R9, -N(alk)-CS-NR8R9, -NH-CO-R10, -NH-CS-R20, -NH-C(=NR21)-NR7R9, -N(alk)-C(=NR21)-NR7R9, -NH-SO2-NR7R9, -N(alk)-SO2-NR7R9, -CO-NR7R9, -NH-SO2-CF3, -NH-SO2-alk, -NR9R11, -S(O)m-alk-Ar, -SO2-NR7R9, optionally 3-substituted 2-oxo-1-imidazolidinyl or optionally 3-substituted 2-oxo-1-perhydropyrimidinyl; R3 is an oxygen atom or a NOH, NO-alk-COOX or CH-R13 radical; R4 is an alkyl radical, -alk-Het or -alk-Ar; R5 is a straight or branched C1-11 alkyl radical, -alk-Het or -alk-Ar, or R4 and R5, taken together with the carbon atom to which they are attached, form a cycloalkyl radical; R6 is a hydrogen atom radical or a hydroxy radical, straight or branched C1-11 alkyl, -NR14R15, -alk-OH, -alk-NR14R15, -alk-Ar or -alk-Het; and salts thereof. The compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, particularly NMDA receptor glycine modulation site ligands, and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor.

公开(公告)号：EP0738147A1

公开(公告)日：1996-10-23

申请号：EP95906378.0

申请日：1995-01-09

申请人： RHONE-POULENC RORER S.A.

发明人： DELUMEAU, Jean-Christophe ,  MARTINET, Michel ,  REIBAUD, Michel ,  STUTZMANN, Jean-Marie

IPC分类号： C07D277 ,  A61K31 ,  A61P1 ,  A61P3 ,  A61P21 ,  A61P25

CPC分类号： A61K31/428 ,  A61K31/425

摘要： Application of riluzole or pharmaceutically acceptable salts of said compound for the treatment of mitochondrial diseases such as, for example, the syndrom of KEARNS-SAYRE, the syndrom MERFF, the syndrom MELAS and the disease of LEBER.

公开(公告)号：EP0737248A1

公开(公告)日：1996-10-16

申请号：EP95905172.0

申请日：1994-12-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE

发明人： GIOVANNANGELI, Carine ,  HELENE, Claude

IPC分类号： C12N15 ,  A61K9 ,  A61K31 ,  A61K35 ,  A61K48 ,  A61P31 ,  A61P35 ,  C07H21 ,  C12N7 ,  A61K38

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1132 ,  C12N15/1136 ,  C12N2310/152 ,  C12N2310/53 ,  C12N2310/531 ,  C12N2310/532 ,  Y10S977/802 ,  Y10S977/916 ,  Y10S977/92

摘要： The present invention relates to new vectors, pharmaceutical compositions containing them, and their therapeutical uses. More particularly, it relates to double strand DNA molecules coding for an RNA forming a triple helix with a single strand target nucleic acid. Said molecules act very selectively and efficiently on the expression of genes.

公开(公告)号：EP0722496A1

公开(公告)日：1996-07-24

申请号：EP94928933.0

申请日：1994-09-29

申请人： RHONE-POULENC RORER S.A.

发明人： MALLET, Jacques ,  REVAH, Frédéric ,  STUTZMANN, Jean-Marie

IPC分类号： C12N15 ,  A61K31 ,  A61K48 ,  A61P25 ,  A61P43 ,  C07K14 ,  C12N7 ,  A61K38

CPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  C12N15/1135 ,  C12N15/86 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2710/10343 ,  C12N2799/021

摘要： The present invention relates to the utilization of compounds capable of inhibiting the activity of the proteine p53 for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases.

公开(公告)号：EP0679161A1

公开(公告)日：1995-11-02

申请号：EP94904199.0

申请日：1994-01-03

申请人： RHONE-POULENC RORER S.A.

发明人： DUBROEUCQ, Marie-Christine ,  MANFRE, Franco

IPC分类号： C07D277 ,  A61K31 ,  A61K38 ,  A61P1 ,  A61P3 ,  A61P25 ,  A61P43 ,  C07K5

CPC分类号： C07K5/06026 ,  A61K38/00

摘要： Derivatives of formula (I), their salts, the preparation of said derivatives and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for cholecystokinin (CCK) and gastrin receptors and are therefore useful in the treatment and prevention of CCK and gastrin-related disorders affecting the nervous system and gastrointestinal tract.

公开(公告)号：EP0678022A1

公开(公告)日：1995-10-25

申请号：EP94903934.0

申请日：1994-01-03

申请人： RHONE-POULENC RORER S.A.

发明人： PRATT, Jérémy ,  STUTZMANN, Jean-Marie

IPC分类号： C07D277 ,  A61K9 ,  A61K31 ,  A61P39 ,  A61P43

CPC分类号： A61K31/425 ,  Y10S514/917

摘要： Application of riluzole or its pharmaceutically acceptable salts in the preparation of drugs having radiorestoring properties.

公开(公告)号：EP0671912A1

公开(公告)日：1995-09-20

申请号：EP94900881.0

申请日：1993-11-26

申请人： RHONE-POULENC RORER S.A.

发明人： BOBEE, Jean-Marc ,  DE LANTY, Patrick ,  GUERIN, Gilles ,  VEILLARD, Michel

IPC分类号： A61K9 ,  A61K31 ,  A61K47 ,  A61P35

CPC分类号： A61K31/335 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/26 ,  A61K47/44

摘要： Novel taxoid derivative based compositions consisting of solutions of said derivatives in a surfactant, and being used for preparing infusion solutes.

公开(公告)号：EP0581846A1

公开(公告)日：1994-02-09

申请号：EP92910133.0

申请日：1992-04-21

申请人： RHONE-POULENC RORER S.A.

发明人： BARON, Jean-Pierre ,  BRUN, André ,  HEMKER, Hendrik ,  UZAN, André

IPC分类号： C08B37 ,  A61K31 ,  A61K45 ,  A61P7

CPC分类号： A61K31/715 ,  A61K31/727 ,  A61K45/06 ,  C08B37/0078

摘要： L'invention concerne de nouveaux mélanges d'oligosaccharides sulfatés présentant la structure générale des oligosaccharides constitutifs de l'héparine, ayant une masse moléculaire moyenne de 6U0,6kD, une polydispersité proche de 1, et la capacité d'inhiber la génération de thrombine. L'invention concerne également leur préparation et des compositions pharmaceutiques les contenant.

摘要翻译： 本发明涉及一种具有肝素的具有平均分子量6U0,6kD的，接近1的多分散性，并抑制凝血酶产生的能力的构成的低聚糖的一般结构的硫酸化寡糖的新混合物。 本发明还涉及它们的制备和含有它们的药物组合物。

公开(公告)号：EP0821741A1

公开(公告)日：1998-02-04

申请号：EP96913579.0

申请日：1996-04-12

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： CHEN, Ruihuan ,  DOIRON, Bruno ,  KAHN, Axel

IPC分类号： C12N15 ,  A61K35 ,  A61K48 ,  A61P3 ,  C12N5 ,  C12N7

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/85 ,  C12N2740/13043 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/85

摘要： A defective recombinant virus including at least one heterologous gene controlled by a glucose-inducible expression signal, a pharmaceutical composition containing same, and cells transformed using said vector, are disclosed.

公开(公告)号：EP0809704A1

公开(公告)日：1997-12-03

申请号：EP96903077.0

申请日：1996-02-09

申请人： RHONE-POULENC RORER S.A.

发明人： CROUZET, Joel ,  NAUDIN, Laurent ,  ORSINI, Cécile ,  VIGNE, Emmanuelle ,  YEH, Patrice

IPC分类号： C12N15 ,  A61K35 ,  A61K48 ,  C12N1 ,  C12N7 ,  C12R1

CPC分类号： C12N15/86 ,  C12N7/00 ,  C12N15/70 ,  C12N2710/10343 ,  C12N2710/10351

摘要： A novel method for preparing recombinant adenoviruses and the use of such adenoviruses in gene therapy are disclosed. Plasmids used in the construction of said adenoviruses are also disclosed.