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    POLYCLONAL MIXTURES OF ANTIBODIES, AND METHODS OF MAKING AND USING THEM
    34.
    发明公开
    POLYCLONAL MIXTURES OF ANTIBODIES, AND METHODS OF MAKING AND USING THEM 审中-公开

    公开(公告)号：EP3080158A4

    公开(公告)日：2018-03-21

    申请号：EP14870113

    申请日：2014-12-09

    申请人： ADIMAB LLC

    发明人： WALKER LAURA M ,  KRAULAND ERIC ,  WITTRUP KARL DANE

    IPC分类号： C07K16/00 ,  A61K39/395

    CPC分类号： G01N33/6854 ,  C07K16/00 ,  C07K16/005 ,  C07K2317/10 ,  G01N33/6878

    摘要： A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies. Host cells expressing antibodies that bind to the antigen are then collected from among the first plurality of host cells, and a composition is prepared comprising a polyclonal mixture of antibodies expressed by these host cells. A second sample of the antigen of interest is then contacted with an aliquot of the prepared composition and a second plurality of host cells collectively expressing a second library of antibodies. Host cells expressing antibodies that bind to the second sample of the antigen are then collected from among the second plurality of host cells.