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1.发明公开METHODS FOR PURIFYING HETERODIMERIC MULTISPECIFIC ANTIBODIES FROM PARENTAL HOMODIMERIC ANTIBODY SPECIES 审中-公开从亲本同源抗体种类中纯化异二聚体多特异性抗体的方法
公开(公告)号：EP3280444A1
公开(公告)日：2018-02-14
申请号：EP16777345.6
申请日：2016-04-08
申请人： Adimab, LLC
IPC分类号： A61K39/395 , A61K39/44 , C12P21/08 , B01D15/36 , B01J20/282 , B01J39/08
CPC分类号： C07K16/00 , B01D15/166 , B01D15/168 , B01D15/36 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J39/26 , B01J41/20 , C07K1/18 , C07K2317/21 , C07K2317/31 , C07K2317/515 , C07K2317/52
摘要： Methods for purifying multispecific antibodies on interest (MAIs) that co-engage at least two different antigens or epitopes (also referred to targets, used interchangeably throughout), from compositions comprising the MAI and parental homodimeric antibody species are provided, as well as reagents which may be used to practice such methods.
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2.发明公开
公开(公告)号：EP3621641A1
公开(公告)日：2020-03-18
申请号：EP18798898.5
申请日：2018-05-08
申请人： Adimab, LLC
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公开(公告)号：EP2593594B1
公开(公告)日：2017-09-27
申请号：EP11807533.2
申请日：2011-07-14
申请人： Adimab, LLC
IPC分类号： C07K16/00
CPC分类号： C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , C40B50/06 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
摘要翻译： 本发明通过特异性地设计具有定向序列和长度多样性的文库克服了用于产生编码抗体的多核苷酸文库的已知方法中固有的不足之处。
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公开(公告)号：EP3741883A1
公开(公告)日：2020-11-25
申请号：EP20152442.8
申请日：2011-07-14
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：EP2593594A2
公开(公告)日：2013-05-22
申请号：EP11807533.2
申请日：2011-07-14
申请人： Adimab LLC
IPC分类号： C40B30/04
CPC分类号： C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , C40B50/06 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：EP4219805A1
公开(公告)日：2023-08-02
申请号：EP22213061.9
申请日：2011-07-14
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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公开(公告)号：EP4031568A1
公开(公告)日：2022-07-27
申请号：EP20866077.9
申请日：2020-09-18
申请人： Adimab, LLC
IPC分类号： C07K16/00
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公开(公告)号：EP3336225A1
公开(公告)日：2018-06-20
申请号：EP17192812.0
申请日：2011-07-14
申请人： Adimab, LLC
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
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9.发明公开RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR 审中-公开合成酶抗生素基因组DNA设计在VERWENDUNGEN DAVON
公开(公告)号：EP3124497A2
公开(公告)日：2017-02-01
申请号：EP16169483.1
申请日：2008-09-12
申请人： Adimab, LLC
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： The present disclosure provides methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译： 本公开提供了通过专门设计具有定向序列和长度多样性的文库来产生抗体编码多核苷酸文库的方法。 这些图书馆的设计旨在反映人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开的人抗体序列数据库而获得的合理设计。
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