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47 条记录 (耗时 0.013 秒)

    New Carnitine salts particularly suitable for oral use
    33.
    发明公开
    New Carnitine salts particularly suitable for oral use 失效
    特别地，对于Carniting的口服使用的合适的盐。

    公开(公告)号：EP0207437A1

    公开(公告)日：1987-01-07

    申请号：EP86108678.3

    申请日：1986-06-25

    申请人： BIORESEARCH S.p.A.

    发明人： Gennari, Federico

    IPC分类号： C07C101/30 ,  C07C99/00 ,  C07C143/02 ,  C07C139/00 ,  A61K31/195

    CPC分类号： C07C309/00

    摘要： New carnitine salts with sulphonic acids, of general formula:
    in which R is a linear or branched alkyl chain of 8 to 18 carbon atoms, and which are particularly suitable for oral use.
    Said salts are prepared by the following stages:

    a) preparing an aqueous solution of carnitine inner salt;
    b) preparing an aqueous solution of a sulphonic acid of formois RSO 3 H in which R has the aforesaid meaning;
    c) rescling the carnitine inner salt with the sulphonic acid in aqueous solution, and recovering the salt produced by oryin the solution.

    New cytidine-diphosphocholine salts, particularly suitable for oral use
    34.
    发明公开
    New cytidine-diphosphocholine salts, particularly suitable for oral use 失效
    胞苷二磷酸盐，特别是适合于口服使用。

    公开(公告)号：EP0207436A2

    公开(公告)日：1987-01-07

    申请号：EP86108677.5

    申请日：1986-06-25

    申请人： BIORESEARCH S.p.A.

    发明人： Gennari, Federico

    IPC分类号： C07H19/10 ,  A61K31/70

    CPC分类号： C07H19/10

    摘要： New cytidine-diphosphocholine (CDP-choline) salts with long-alkyl chain sulphonic acids suitable for injectable pharmaceutical formulations, but more specifically for oral formulations.
    Said salts are prepared by a process comprising preparing an aqueous solution of basic CDP-choline, preparing an aqueous sulphonic acid solution, reacting these two solutions together to obtain the required salt, and recovering this salt with a high degree of purity.

    Stable S-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle
    37.
    发明公开
    Stable S-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle 失效
    稳定的S-腺苷甲硫氨酸盐，其制备方法和包含它们作为活性成分的治疗组合物

    公开(公告)号：EP0073376A1

    公开(公告)日：1983-03-09

    申请号：EP82107333.5

    申请日：1982-08-12

    申请人： BIORESEARCH S.p.A.

    发明人： Gennari, Federico

    IPC分类号： C07H19/16 ,  A61K31/70

    CPC分类号： C07H19/16

    摘要： S-adenosylmethionine salts have been prepared wich are stable even at elevated temperatures for practically indefinite time periods, and which correspond to the formula
    in which X is the acid equivalent of a strong mineral acid of pK less than 2.5, and n is 4, 5 or 6.
    The new salts are practically free from toxicity, and find application in numerous fields of human therapy.

    摘要翻译： 已经制备了S-腺苷甲硫氨酸盐，即使在升高的温度下实际上无限期的时间也是稳定的，并且其对应于其中X是pK小于2.5的强无机酸的酸当量，并且n是4,5 或6.新盐实际上没有毒性，并且可用于人类治疗的许多领域。