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公开(公告)号：EP4276466A1
公开(公告)日：2023-11-15
申请号：EP22736576.4
申请日：2022-01-07
发明人： LIU, Jiawang , FAN, Fei , LIU, Yang , WANG, Licui , LEE, Kyoung Woo
IPC分类号： G01N33/574 , C12N15/13 , C07K16/28 , A61P35/00 , A61K39/00
摘要： Provided are an antibody specifically binding to PD-L1 and an antigen-binding fragment thereof. The antibody and the antigen-binding fragment thereof have high specificity and stability, can specifically block a PD-L1-SIPRα pathway, do not cause hemagglutination within a certain concentration range, and thus can significantly suppress tumor growth in vivo.
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公开(公告)号：EP4276113A1
公开(公告)日：2023-11-15
申请号：EP22736574.9
申请日：2022-01-07
发明人： LIU, Yang , GU, Mingyue , LI, Xiaochun , WANG, Licui , LIU, Jiawang , LEE, Kyoung Woo
摘要： Provided are an antibody specifically binding to CD47 and an antigen-binding fragment thereof. The antibody and the antigen-binding fragment thereof have high specificity and stability, can specifically block a CD47-SIPRα pathway, do not cause hemagglutination within a certain concentration range, and thus can significantly suppress tumor growth in vivo.
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公开(公告)号：EP4269395A1
公开(公告)日：2023-11-01
申请号：EP21911371.9
申请日：2021-12-14
发明人： CHOI, Jae Yul , KIM, Won Jeoung , KIM, Ji Sook , KIM, Min Jeong , PARK, Won Gi , AHN, Young Gil , BAE, In Hwan
IPC分类号： C07D239/94 , A61K31/5377 , A61K31/517 , A61P35/00 , C07D403/04 , C07D405/12 , C07D409/12
摘要： The present invention relates to a novel quinazoline derivative compound as a SOS1 inhibitor and to uses thereof. More particularly, the present invention relates to a novel quinazoline derivative compound having inhibitory activity on SOS1 binding to RAS family proteins and/or RAC1, to pharmacologically acceptable salts thereof, and to pharmaceutical compositions comprising such compounds.
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34.发明公开
公开(公告)号：EP3878870A1
公开(公告)日：2021-09-15
申请号：EP19881762.9
申请日：2019-11-05
发明人： LIU, Jiawang , YANG, Yaping , SONG, Nanmeng , XIAO, Wenchu , CHUNG, Chulwoong , KIM, Maengsup
IPC分类号： C07K16/28 , C07K16/24 , C07K16/32 , C07K16/46 , C07K14/54 , C12N15/13 , A61K47/68 , A61K39/395
摘要： Provided are an anti-TNFa/anti IL-17A natural antibody structure-like heterodimer form of a bispecific antibody and a preparation methodtherefor, wherein the antibody can bind two target molecules simultaneously, and can be used for treating complex diseases.
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公开(公告)号：EP3849964A1
公开(公告)日：2021-07-21
申请号：EP19859287.5
申请日：2019-09-12
发明人： BAEK, Jong Ouk , KIM, Hee Cheol , HA, Tae Hee , SUH, Kweehyun
IPC分类号： C07D239/94 , A61K31/517
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36.发明公开
公开(公告)号：EP3670500A1
公开(公告)日：2020-06-24
申请号：EP18847012.4
申请日：2018-08-17
发明人： ZHAO, Tao , WEI, Dong , LI, Min , KIM, Maeng Sup , CHUNG, Chul Woong
IPC分类号： C07D239/48 , C07D413/12 , C07D413/14 , C07D498/00 , A61K31/506 , A61P35/00 , A61P29/00 , A61P37/00
摘要： Provided are a pyrimidinyl amino compound having protein kinase inhibitor activity, and a pharmaceutical composition containing said compound; also provided are a use and application of said compound. What is provided is selected from a group consisting of the compound represented by formula (I), a stereoisomer thereof, a tautomer thereof, a pharmacologically acceptable salt thereof, a solvate thereof, and a prodrug thereof. The described compound has good inhibitory activity against the JAK family of kinases and the SYK family of kinases, and therefore may serve as a JAK inhibitor and SYK inhibitor, and is effective in use for the prevention or treatment of diseases related to the JAK and SYK families of kinases.
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37.发明公开
公开(公告)号：EP3608341A1
公开(公告)日：2020-02-12
申请号：EP18777419.5
申请日：2018-03-28
发明人： LIU, Jiawang , SONG, Nanmeng , YANG, Yaping , JIN, Mengxie
IPC分类号： C07K16/46 , C07K16/30 , A61K39/395 , C12N15/13 , A61P35/00
摘要： Provided are an anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and a preparation thereof. In particular, provided are a highly stable heterodimeric anti-PD-L1/anti-PD-1 bispecific antibody with characteristics of a natural IgG and without mismatches heavy chain-light chain, and a preparation thereof. The bispecific antibody can bind to both target molecules and is more effective in treating a complex disease.
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公开(公告)号：EP3252038A4
公开(公告)日：2018-08-01
申请号：EP16742703
申请日：2016-01-22
发明人： XUE HAI , ZHAO TAO , CHA MI YOUNG , KIM MAENGSUP
IPC分类号： C07D209/08 , A61K31/404 , A61P29/00 , C07D209/10
CPC分类号： A61K31/404 , A61K31/03 , A61K31/192 , A61K31/196 , C07D209/08 , C07D209/10 , Y02A50/409
摘要： Disclosed are a compound, a stereisomer and a tautomer thereof, a pharmaceutically acceptable salt thereof, and a solvate or a prodrug thereof, which can be used for preventing or treating a ROR³ mediated disease. The compound has the structural formula (I).
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公开(公告)号：EP3336090A1
公开(公告)日：2018-06-20
申请号：EP16834688.0
申请日：2016-08-12
发明人： XU, Jiangcheng , CAI, Qingyuan , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D487/04 , A61K31/4162 , A61P29/00
摘要： Disclosed are a compound related to inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (especially humans). The compound has a structural formula I.
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40.发明公开BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF 审中-公开BIFUNKTIONELLES FUSIONSPROTEIN，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP3101035A4
公开(公告)日：2017-07-19
申请号：EP15742538
申请日：2015-01-28
发明人： CHEN GUOQIANG , LIU JIAWANG , SONG NANMENG , YANG YAPING , CHA MI YOUNG
IPC分类号： C07K19/00 , A61K38/17 , A61K39/395 , A61P37/02 , C07K14/705 , C07K16/24 , C12N5/10 , C12N15/62 , C12N15/63
CPC分类号： C07K16/244 , A61K38/00 , A61K39/00 , C07K14/7051 , C07K14/70521 , C07K16/24 , C07K2317/24 , C07K2317/92 , C07K2319/00
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