公开(公告)号：EP1558591A2

公开(公告)日：2005-08-03

申请号：EP03773201.3

申请日：2003-10-07

申请人： The Regents of the University of California ,  Universita Degli Studi di Urbino ,  Universita Degli Studi di Parma

发明人： PIOMELLI, Daniele ,  DURANTI, Andrea ,  TONTINI, Andrea ,  MOR, Marco ,  TARZIA, Georgio

IPC分类号： C07D271/00 ,  A61K31/21

CPC分类号： C07C311/29 ,  C07C271/56 ,  C07C275/54 ,  C07C2601/14 ,  C07D209/08 ,  C07D211/06 ,  C07D215/06 ,  C07D307/79 ,  C07D487/04

摘要： Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that, if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula (I) and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.

公开(公告)号：EP2811258B1

公开(公告)日：2016-02-17

申请号：EP14425066.9

申请日：2014-05-30

申请人： Universita' Degli Studi di Roma "La Sapienza" ,  Universita' degli Studi di Napoli "Federico II" ,  ICFO - Institut de Ciencies Fotoniques ,  Universidade Federal Do Rio De Janeiro ,  National University of Singapore

发明人： D'Ambrosio, Vincenzo ,  Spagnolo, Nicolò ,  Del Re, Lorenzo ,  Marrucci, Lorenzo ,  Slussarenko, Sergei ,  Aolita, Mario Leando ,  Walbron, Stephen Patrick ,  Kwek, Leong Chuan ,  Li, Ying ,  Sciarrino, Fabio

IPC分类号： G01B11/26 ,  G01C1/00 ,  G06N99/00 ,  G01D5/34

CPC分类号： G01B11/26 ,  G01C9/00 ,  G01D5/344 ,  H04B10/70

公开(公告)号：EP2560949B1

公开(公告)日：2015-12-02

申请号：EP11716208.1

申请日：2011-04-15

申请人： Università degli Studi di Roma "La Sapienza" ,  Fondazione Ieo ,  Universita' Degli Studi Di Pavia ,  Universita' degli Studi di Milano

发明人： MINUCCI, Saverio ,  MAI, Antonello ,  MATTEVI, Andrea

IPC分类号： C07C233/43 ,  C07C233/44 ,  C07C233/80 ,  C07C271/22 ,  C07C271/28 ,  C07C275/24 ,  C07D333/60 ,  A61K31/167 ,  A61K31/17 ,  A61K31/325 ,  A61K31/381 ,  A61P35/00 ,  A61P31/12

CPC分类号： C07C271/26 ,  C07C233/44 ,  C07C233/80 ,  C07C259/06 ,  C07C271/22 ,  C07C271/28 ,  C07C275/24 ,  C07C2601/02 ,  C07C2601/14 ,  C07D333/60

公开(公告)号：EP2720694A1

公开(公告)日：2014-04-23

申请号：EP12734825.8

申请日：2012-06-13

申请人： Azienda Ospedaliera Universitaria Integrata di Verona ,  Universita' degli Studi di Ferrara ,  Universita' Degli Studi di Bari ,  Rare Partners S.r.l.

发明人： CABRINI, Giulio ,  CASAVOLA, Valeria ,  GAMBARI, Roberto

IPC分类号： A61K31/37 ,  A61K31/443 ,  A61K31/47 ,  A61P11/00

CPC分类号： A61K31/366 ,  A61K31/37 ,  A61K31/443 ,  A61K31/47 ,  A61K2300/00

摘要： The invention relates to the use of 4,6,4 '-trimethylangelicin (TMA) and structural analogues thereof to prepare a medicament for the treatment of cystic fibrosis with the primary objective of correcting the defective CFTR in a sub-group of cystic fibrosis patients consisting of patients carrying the F508del-CFTR mutation.

公开(公告)号：EP2686661A1

公开(公告)日：2014-01-22

申请号：EP12714976.3

申请日：2012-03-14

申请人： UNIVERSITA DEGLI STUDI DI CAGLIARI ,  UNIVERSITA' DEGLI STUDI DI SASSARI

发明人： SPIGA, Saturnino ,  DIANA, Marco

IPC分类号： G01N1/30

CPC分类号： G01N33/56966 ,  G01N1/30

摘要： A method of visualization and characterization of the nervous system, which combines two techniques for tissue staining, mercuric impregnation and immunohistochemistry, is described. The method disclosed makes compatible one with the other procedures of staining by carrying them out on tissues subjected to adequate fixing procedures. Thus, the method makes feasible to combine morphometric analysis, which can typically be carried out with mercuric impregnation, with antigenic and/or neurochemical cellular characterization, which can typically be obtained with immunohistochemistry. The method has proven simple, reliable, and suitable for both conventional microscopy and confocal laser scanning microscopy.

公开(公告)号：EP1706103B1

公开(公告)日：2013-07-10

申请号：EP04803101.7

申请日：2004-11-02

申请人： Universita' degli Studi di Milano ,  Conte, Ubaldo ,  Torre, Maria Luisa ,  Universita' degli Studi di Bologna

发明人： VIGO, Daniele Università Degli Studi di Milano ,  RUSSO, Vincenzo Università Degli Studi di Milano ,  FAUSTINI, Massimo Univ. Degli Studi di Milano ,  STACCHEZZINI, Simona Univ. Degli Studi di Milano ,  CONTE, Ubaldo Università Degli Studi di Pavia ,  TORRE, Maria Luisa Univ. Degli Studi di Pavia ,  ACCORSI, Pier Attilio Univ. Degli Studi di Bologna ,  GALEATI, Giovanna Univ. Degli Studi di Bologna ,  SPINACI, Marcella Univ. Degli Studi di Bologna

IPC分类号： A61K9/50 ,  C12N5/00

CPC分类号： C12N5/0609 ,  A61K9/5036 ,  A61K35/48 ,  C12N5/0012 ,  C12N2502/243 ,  C12N2533/74

摘要： A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro, and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules are constituted by: a nucleus containing stem cells, ovarian follicular cells, gametes ovarian follicles or mammalian embryos and/or a biocompatible and/or biodegradable polymer; a semi-permeable membrane constituted by a divalent or trivalent metal ion salt of alginic acid, optionally cross-linked on the inner and/or outer surface and/or on both surfaces, optionally vehicularising a second or more cellular species. The cells and follicles prepared and cultivated using this methodology are used for the in vitro and/or in vivo production of peptides, proteins, antibodies, hormones and hormone precursors, metabolites and catabolites typical of these cellular structures, plasma membranes, nuclear membranes, cytoplasmic organelles, somatic cell nuclei or gametes and embryos.

公开(公告)号：EP2013217A1

公开(公告)日：2009-01-14

申请号：EP06754964.2

申请日：2006-05-02

申请人： Universita' degli Studi di Roma " Tor Vergata" ,  Universita' Degli Studi di Teramo

发明人： MACCARRONE, Mauro ,  ODDI, Sergio ,  FEZZA, Filomena ,  FINAZZI AGRO', Alessandro

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  G01N33/948

摘要： The present invention relates to the synthesis and characterisation of biotinylated analogue of N- arachidonoylethanolamine (AEA) and its use as a tool to study AEA transport and trafficking through biochemical and morphological techniques . In particular biotinylated AEA (b-AEA, for which we propose the common name MM22) is suitable to design highly sensitive and simple methods for the non-radioactive detection and quantitation of AEA from complex samples, which would offer a useful alternative approach to the routinely used radiometric assays. The invention also relates to the use of b-AEA as a potential therapeutic and diagnostic agent.

公开(公告)号：EP1957631A2

公开(公告)日：2008-08-20

申请号：EP06807444.2

申请日：2006-10-20

申请人： Universita' degli studi di Bari ,  Universita 'Degli Studi Di Foggia

发明人： RANIERI, Elena ,  BATTAGLIA, Michele ,  WOLFGANG, Herr ,  GESUALDO, Loreto

IPC分类号： C12N5/06

CPC分类号： A61K39/0011 ,  A61K2039/5152

摘要： The present invention relates to a renal carcinoma cell line capable of activating the immune system in an antigen-specific manner. According to a further aspect, the invention also includes derivatives of the cell line that maintain said activation capacity. The invention also comprises a method for targeting and activating immune system cells against cells of clear cell renal carcinoma. Said method comprises the co-incubation of isolated immune system cells (dendritic cells, CD4*, CD8* lymphocytes etc.) with cells of the RCC BA85#21 line in accordance with the invention in a suitable culture medium, for a time sufficient to obtain antigen specific cells.

公开(公告)号：EP1868588A2

公开(公告)日：2007-12-26

申请号：EP06727411.8

申请日：2006-04-03

申请人： UNIVERSITA' DEGLI STUDI DI MILANO ,  Universita' Degli Studi Di Pavia

发明人： VIGO, Daniele ,  TORRE, Maria, Luisa ,  FAUSTINI, Massimo ,  MUNARI, Eleonora ,  RUSSO, Vincenzo ,  CONTE, Ubaldo

IPC分类号： A61K9/50 ,  A61K35/52 ,  A61D19/02

CPC分类号： A61K35/52 ,  A61D19/022 ,  A61K9/501 ,  A61K9/5036 ,  A61K9/5089

摘要： Capsules or microcapsules comprising: a) a nucleus containing seminal material or the spermatozoa of animal species chosen from the group consisting of equids, buffalo, ovicaprids, canids, felids, lagomorphs, laboratory animal species chosen from mice and rats, and possibly man, b) a membrane of a bivalent or trivalent metal alginate.

公开(公告)号：EP1169351A1

公开(公告)日：2002-01-09

申请号：EP00926869.9

申请日：2000-04-11

申请人： UNIVERSITA' DEGLI STUDI DI MILANO ,  Universita' Degli Studi di Firenze

发明人： CHILLEMI, Francesco ,  FRANCESCATO, Pierangelo ,  ZICHE, Marina

IPC分类号： C07K14/78 ,  A61K38/39

CPC分类号： C07K14/78 ,  A61K38/00

摘要： Polypeptides with sequence corresponding or homologous to that of endostatin, having inhibiting activity on angiogenesis, are useful in the treatment of angiogenesis-dependent tumors.