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公开(公告)号：EP1019510A1
公开(公告)日：2000-07-19
申请号：EP98946547.1
申请日：1998-10-01
发明人： ALLAN, Gordon , MEEHAN, Brian , CLARK, Edward , ELLIS, John , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , MCNEILLY, Francis
CPC分类号： C07K14/005 , A23C19/0321 , A23C19/0323 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10043
摘要： The invention concerns porcine circovirus strains isolated from pulmonary and ganglionary specimens derived from livestock suffering from postweaning multisystemic wasting syndrome (PMWS). It concerns purified preparations of said strains, attenuated or inactivated standard vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as diagnostic reagents and methods. The invention also concerns DNA fragments useful for producing subunits in a expression vector in vitro or as sequences to be integrated in an expression vector in vivo of virus or plasmid type.
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32.发明公开
公开(公告)号：EP0888777A2
公开(公告)日：1999-01-07
申请号：EP98108774.5
申请日：1992-12-11
IPC分类号： A61K39/265 , C07K14/03 , C12N15/38
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/70 , C12N15/86 , C12N2710/10343 , C12N2710/14143 , C12N2710/16622 , C12N2710/16634 , C12N2710/16722 , C12N2710/16734 , C12N2710/16771 , C12N2710/24143 , C12N2830/30 , G01N33/6854 , G01N2333/03
摘要： Recombinant subunit vaccines against bovine herpesvirus type 1 (BHV-1) are provided, as well as methods of vaccination and methods of recombinantly producing the subunit antigens or nucleotide sequences employed in the vaccines. Preferably, the subunit is a truncated BHV-1 gIV antigen.
摘要翻译： 提供了针对牛疱疹病毒1型（BHV-1）的重组亚单位疫苗，以及疫苗接种方法和重组产生疫苗中使用的亚基抗原或核苷酸序列的方法。 优选地，亚基是截短的BHV-1 gIV抗原。
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公开(公告)号：EP0635055B1
公开(公告)日：1998-12-23
申请号：EP93907710.3
申请日：1993-04-05
发明人： POTTER, Andrew, A. , PONTAROLLO, Reno, A. , PFEIFFER, Cheryl, G. , THEISEN, Michael , HARLAND, Richard, J. , RIOUX, Clement
IPC分类号： C12N15/31 , C07K14/195 , C12P21/02 , A61K39/102 , C12N1/21
CPC分类号： C07K14/285 , A61K39/00 , C07K2319/40 , C07K2319/55
摘要： Novel Haemophilus somnus immunogenic proteins are disclosed. The proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections. The proteins are conveniently produced using recombinant technology.
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34.发明授权ASSEMBLED VIRAL PARTICLES AND THEIR USE IN A VACCINE TO ROTAVIRAL DISEASE 失效同声问病毒粒子和它们在疫苗诱导ROTAVIRENKRANKHEIT
公开(公告)号：EP0652957B1
公开(公告)日：1997-05-07
申请号：EP91917981.2
申请日：1991-10-24
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2720/12322 , C12N2720/12323 , Y10S530/826
摘要： Assembled viral particles derived from rotavirus proteins are disclosed. The assembled particles include the inner capsid protein, VP6, in combination with either or both of the outer capsid proteins, VP4 and VP7. These assemblies can be used in vaccine compositions for the treatment and prevention of rotaviral disease.
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公开(公告)号：EP0660723B1
公开(公告)日：1996-08-21
申请号：EP92902950.2
申请日：1992-01-29
CPC分类号： A61K9/5184 , A61K38/2013 , A61K38/217 , A61K47/6901 , C07K14/005 , C12N2710/14143 , C12N2720/12322
摘要： Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.
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公开(公告)号：EP0610260A1
公开(公告)日：1994-08-17
申请号：EP92921223.0
申请日：1992-10-21
CPC分类号： C07K14/285 , A61K39/00
摘要： On décrit de nouveaux vaccins agissant contre l'Actinobacillus pleuropneumoniae. Ils contiennent au moins une protéine de liaison à la transférine d'A. pleuropneumoniae et/ou une cytolysine d'A. pleuropneumoniae et/ou une APP4 d'A. pleuropneumoniae. On décrit aussi les séquences d'ADN codant pour ces protéines, les vecteurs comportant ces séquences et les cellules hôtes transformées par ces vecteurs. On peut utiliser ces vaccins pour traiter ou prévenir les infections respiratoires porcines.
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37.发明公开ALIPHATIC PROPARGYLAMINES AS SELECTIVE MAO-B INHIBITORS AND AS NEUROPROTECTIVE AGENTS 失效脂族炔丙胺作为选择性MAO-B抑制剂和作为神经保护剂。
公开(公告)号：EP0573498A1
公开(公告)日：1993-12-15
申请号：EP92905512.0
申请日：1992-02-28
发明人： YU, Peter, H. 378 Waterloo Crescent , DAVIS, Bruce, A. 819 Copper Mine Crescent , BOULTON, Alan, A. 424 Spadina East, 1540
CPC分类号： C07C211/23 , C07C215/08 , C07C229/12
摘要： L'invention concerne une série de propargylamines, leurs sels et des compositions pharmaceutiques contenant un composé de la formule (III), dans laquelle R1, R3 et R4 sont identiques ou différents et représentent hydrogène ou un alkyle inférieur à chaîne droite ou ramifié; y est un nombre entier de 0 à 5; z est un nombre entier de 0 à 5; et R2 représente un groupe alkyle, alcényle, alcynyle, alcoxy, alkylthio ou alkylsulfinyle à chaîne droite ou ramifié présentant de 3 à 11 atomes de carbone, ledit groupe étant non substitué ou substitué par au moins l'un des substituants choisis parmi hydroxy, aldéhyde, oxo, acyloxy inférieur, halogène, thio, sulfoxyde, suflone phényle, phényle substitué par halogène, phényle substitué par hydroxy, cycloalkyle présentant de 3 à 6 atomes de carbone et des substituants hétérocycliques présentant entre 3 et 6 atomes, dont de 1 à 3 sont de hétéroatomes choisis parmi O, S et/ou N, et leurs sels pharmaceutiquement acceptables, mélangés avec un porteur, excipient ou adjuvant pharmaceutiquement acceptable. Les composés sont utiles en tant qu'inhibiteurs sélectifs de monoamine oxydase B et possèdent des propriétés neuroprotectrices prouvées dans la médecine humaine et vétérinaire.
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公开(公告)号：EP4298126A1
公开(公告)日：2024-01-03
申请号：EP22758674.0
申请日：2022-02-25
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39.发明授权METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION 有权方法和组合物可用于治疗和预防滋贺县生产大肠杆菌感染
公开(公告)号：EP2417165B1
公开(公告)日：2016-05-25
申请号：EP10761153.5
申请日：2010-04-06
发明人： POTTER, Andrew, A. , ASPER, David , ROGAN, Dragan
IPC分类号： C07K19/00 , A61K39/108 , A61K39/385 , A61P31/04 , A61P37/04 , C07K14/245
CPC分类号： A61K39/0258 , A61K2039/552 , A61K2039/55566 , A61K2039/6037 , C07K16/1232 , Y02A50/474
摘要： Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC O157 and at least one other STEC serotype.
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公开(公告)号：EP2954043A1
公开(公告)日：2015-12-16
申请号：EP13874703.5
申请日：2013-02-05
IPC分类号： C12N1/20 , A01H17/00 , A01H5/10 , A01N63/02 , A01N63/04 , A01P21/00 , A01P3/00 , B09C1/10 , C12N1/14 , C12N15/00
CPC分类号： A01N63/04 , A01H17/00 , A01N63/00 , A01N63/02 , B09C1/105 , C12R1/465 , C12R1/645 , C12R1/80 , A01N25/00
摘要： The present disclosure provides novel endophyte strains or cultures thereof that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.
摘要翻译： 本公开提供与植物具有共生关系的新颖的内生真菌菌株或其培养物。 本公开进一步提供了在胁迫和不受胁迫的环境条件下改善种子活力，生物和非生物胁迫抗性，植物健康和产量的方法，包括用新颖的内生真菌菌株接种种子并从中培养植物。
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