公开(公告)号：EP1893176B1

公开(公告)日：2013-01-02

申请号：EP06763420.4

申请日：2006-05-31

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  ASCHERL, Hermann

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/26 ,  A61K9/48 ,  A61K31/55 ,  A61K31/426 ,  A61K31/5415 ,  A61K31/4174 ,  A61K31/495 ,  A61K31/496 ,  A61K31/405 ,  A61K31/07

CPC classification number: A61K9/146 ,  A61K31/07 ,  A61K31/405 ,  A61K31/4174 ,  A61K31/426 ,  A61K31/495 ,  A61K31/496 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/55

公开(公告)号：EP2477606A1

公开(公告)日：2012-07-25

申请号：EP10754933.9

申请日：2010-09-17

Applicant: BASF SE

Inventor： KOLTER, Karl ,  DJURIC, Dejan ,  FISCHER, Stefan

IPC: A61K9/14 ,  A61K47/10 ,  A61K47/34 ,  A61K31/00

CPC classification number: A61K9/146 ,  A61K31/192 ,  A61K31/216 ,  A61K31/4174 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/58 ,  A61K47/10 ,  A61K47/34

Abstract: The invention relates to dosage forms containing preparations of active substances having a low-solubility in water in a polymer matrix comprising amphiphilic polyether-copolymers and at least one hydrophilic polymer, the active substance having a low-solubility in water being present in the polymer matrix in an amorphous form.

公开(公告)号：EP2349218A1

公开(公告)日：2011-08-03

申请号：EP09783669.6

申请日：2009-10-02

Applicant: BASF SE

Inventor： KOLTER, Karl ,  MASCHKE, Angelika

IPC: A61K9/16 ,  A61K9/20

CPC classification number: A61K9/1694 ,  A61K9/1635 ,  A61K9/2027

Abstract: The invention relates to a method for producing solid, oral dosage forms with a controlled release of active ingredients. Said forms contain a mixture of a) at least one active ingredient, and b) a pre-formulated mixture of polyvinyl acetate and polyvinyl pyrrolidone, said mixture being obtained by combining components a) and b) in an extruder at temperatures of between 50° and 200°C.

公开(公告)号：EP2229151A1

公开(公告)日：2010-09-22

申请号：EP08858493.3

申请日：2008-12-10

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian ,  MEYER-BÖHM, Kathrin

IPC: A61K9/20

CPC classification number: A61K9/2027 ,  A61K9/146 ,  A61K47/20 ,  A61K47/24

Abstract: The invention relates to polymeric, water-soluble salts of poorly water-soluble medicaments, comprising a polymer which is water-soluble at pH 2-13 of anionic character with a poorly-soluble medicament of cationic character.

公开(公告)号：EP2120553A2

公开(公告)日：2009-11-25

申请号：EP07822847.5

申请日：2007-11-23

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  ASCHERL, Hermann ,  DIELEMAN, Cedric ,  KNIERIEM, Torsten ,  KOLTZENBURG, Sebastian ,  TÜRK, Holger

IPC: A01N25/12 ,  A01N25/10 ,  A01N47/24 ,  A01N43/653

CPC classification number: A01N25/12 ,  A01N25/10 ,  A01N47/24 ,  A01N43/653 ,  A01N2300/00

Abstract: The invention relates to a method for production of solid solutions of poorly soluble pesticides, power products obtained by such a method and the use thereof for pesticide formulations.

公开(公告)号：EP1940359A1

公开(公告)日：2008-07-09

申请号：EP06806988.9

申请日：2006-10-05

Applicant: BASF SE

Inventor： MEYER-BÖHM, Kathrin ,  KOLTER, Karl ,  QUADIR, Anisul

IPC: A61K9/16 ,  A61K9/20 ,  C07C57/30

CPC classification number: A61K31/192 ,  A61K9/1688 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2095

Abstract: Disclosed is a directly compressible ibuprofen formulation containing a) 50 to 99 percent by weight of crystalline ibuprofen, b) 1 to 15 percent by weight of a highly dispersible adjuvant having a minimum surface of 100 m2/g, and c) 0 to 40 percent by weight of other adjuvants provided that the total quantity of components a) to c) amounts to 100 percent by weight, at least 50 percent of the surface of the ibuprofen crystals being coated with the highly dispersible adjuvant.

Abstract translation: 一种直接可压片布洛芬制剂，其包含a）50-99重量％的结晶布洛芬，b）1-15重量％的表面积至少为100平方米/克的细分赋形剂，和c）0-40％ 重量的其它赋形剂，条件是组分a）至c）的总量对应于100重量％，其中至少50％的布洛芬晶体的表面被细分散的赋形剂覆盖。

公开(公告)号：EP1893176A1

公开(公告)日：2008-03-05

申请号：EP06763420.4

申请日：2006-05-31

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  ASCHERL, Hermann

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/26 ,  A61K9/48 ,  A61K31/55 ,  A61K31/426 ,  A61K31/5415 ,  A61K31/4174 ,  A61K31/495 ,  A61K31/496 ,  A61K31/405 ,  A61K31/07

CPC classification number: A61K9/146 ,  A61K31/07 ,  A61K31/405 ,  A61K31/4174 ,  A61K31/426 ,  A61K31/495 ,  A61K31/496 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/55

Abstract: The invention relates to a method for producing powdered or granulated solid solutions from poorly-soluble substances which are molecularly dispersed in an auxiliary agent matrix consisting in atomising a solution containing the poorly-soluble active substance and matrix auxiliary agents, in heating the aqueous suspension of the poorly-soluble substance in the presence of the matrix auxiliary agents to temperatures which are higher than the boiling temperature thereof at a normal pressure, in transforming the poorly-soluble active substance into a solution, in solidifying the solution containing said poorly-soluble substance and matrix auxiliary agents by atomising and drying, wherein the spray solution has a temperature ranging from 90 °C to 350 °C prior to be introduced into an atomising device.

公开(公告)号：EP4225821A1

公开(公告)日：2023-08-16

申请号：EP21789644.8

申请日：2021-10-05

Applicant: BASF SE

Inventor： BRANDL, Ferdinand, Paul ,  SMIT, Theo ,  KOLTER, Karl ,  GUTH, Felicitas ,  HAEBERLE, Karl ,  LUCAS, Frederic

IPC: C08G18/08 ,  C08G18/34 ,  C08G18/32 ,  C08G18/75 ,  C08L75/04 ,  A61K47/34 ,  C08G18/12 ,  C08G18/30

公开(公告)号：EP2164460B1

公开(公告)日：2017-08-09

申请号：EP08760350.2

申请日：2008-06-02

Applicant: BASF SE

Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  GEBERT, Silke ,  MEYER-BÖHM, Kathrin ,  MASCHKE, Angelika

IPC: A61K9/00 ,  A61K9/20 ,  A61K47/26

CPC classification number: A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054

公开(公告)号：EP2681264B1

公开(公告)日：2017-08-02

申请号：EP12705868.3

申请日：2012-02-27

Applicant: BASF SE

Inventor： KOLTER, Karl ,  ANGEL, Maximilian ,  LINNER, Bernhard

IPC: C08J3/12 ,  A61K9/28

CPC classification number: C08J3/122 ,  A61K9/2846 ,  C08J2333/12 ,  C08J2333/14