公开(公告)号：EP1186893A3

公开(公告)日：2004-03-24

申请号：EP01307659.1

申请日：2001-09-10

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： Jacobs, Merrit N. ,  Shaw, James D.

IPC分类号： G01N35/10

CPC分类号： G01N35/00594 ,  G01N35/00603 ,  G01N35/10 ,  G01N2035/1055 ,  G01N2035/1062 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A system for detecting and analyzing patient sample quality and/or analytes, while the sample is in the metering tip used to aspirate the sample liquid from an original patient sample container, and also to dispense the liquid onto a slide test element. Spectrophotometric analysis may be done on the sample liquid while it is still in the tip which has been converted into a cuvette. One technique for such analysis is by scanning the cuvette for transmittance in a light-tight enclosure. Near-infrared and adjacent visible radiation may be used, and the absorption spectra of the liquid detected and analyzed. A possible aspect of the present invention relates to enhancing throughput of an analyzer by conducting a sample quality measurement in a process that is parallel to the main analyzer timing cycle. Another possible aspect of the present invention relates to improving performance of the analyzer by sealing the end of the metering tip to spontaneously form a cuvette for holding the sample during the sample quality measurement. Some advantages of the present system and method include improved throughput, the capability to use smaller sample liquid volumes, eliminating any need for a separate supply of cuvettes independent of the metering tips, and providing for detection through a cone of the metering tip rather than through any label, compared to doing the scanning of the sample liquid in a primary patient collection container.

公开(公告)号：EP0953843A3

公开(公告)日：2000-09-06

申请号：EP99303195.4

申请日：1999-04-26

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： Brookes, Ronald F. ,  Jacobs, Merrit N. ,  Lowne, Alan J. ,  Shaw, James D.

IPC分类号： G01N35/10

CPC分类号： G01N35/1016 ,  G01N2035/1025 ,  Y10T436/119163

摘要： A method and apparatus for detecting improper liquid content of a metering tip of an analyzer. The method detects the content or status using radiation between 630 and 2000 nm, and comprises the steps of: a) aspirating the liquid into one of the tips to fill the tip to a nominal level; b) scanning the liquid in the tip by a scanner (16) comprising a light source (18) and a light detector (26), the source and detector being aligned along a direction that is generally normal to the tip axis; c) providing relative motion between the tip and the scanner while the step b) is conducted, so that the scanner scans from a first position below the tip where a pendant drop of the aqueous liquid would be located if present, to a predetermined second position above the first position that represents the nominal level; d) while conducting steps b) and c), separately detecting at each of several portions of the tip between and including the first and second positions, the amount of light transmitted to the detector, so that all liquid-containing levels within the tip are detected; e) comparing the detected light of step d) with light known to be transmitted if liquid is present only at all of the levels, free of air bubbles; and f) flagging the results as being in error if water is detected at the first position; or if it is not detected because of air bubbles at any one of the levels within the tip up to and including the second position; or if it is detected above the second position.

摘要翻译： 一种用于检测分析仪的计量尖端的不适当液体含量的方法和装置。 该方法使用630和2000nm之间的辐射来检测内容或状态，并且包括以下步骤：a）将液体吸入其中一个尖端以将尖端填充到标称水平; b）通过包括光源（18）和光检测器（26）的扫描器（16）扫描尖端中的液体，源和检测器沿着与尖端轴线大致正交的方向对齐; c）在步骤b）进行时，在尖端和扫描仪之间提供相对运动，使得扫描仪从位于下方的第一位置扫描水中液体的悬垂液滴的位置（如果存在）到预定的第二位置 高于名义水平的第一位; d）在执行步骤b）和c）时，分别检测在第一和第二位置之间的包括第一和第二位置的尖端的几个部分的每一个处，传输到检测器的光量，使得尖端内的所有含液体水平为 检测; e）将步骤d）的检测光与已知要传输的光进行比较，如果液体仅在没有气泡的所有水平下存在; 以及f）如果在第一位置检测到水，则将结果标记为错误; 或者如果由于气泡在尖端内的任何一个水平直到并包括第二位置而没有被检测到; 或者如果它被检测到高于第二位置。

公开(公告)号：EP1027932A2

公开(公告)日：2000-08-16

申请号：EP00301086.5

申请日：2000-02-11

申请人： Ortho-Clinical Diagnostics, Inc.

发明人： Jacobs, Merrit N. ,  Ding, Zhong ,  Brookes, Ronald F.

IPC分类号： B01L3/02 ,  G01N1/38

CPC分类号： B01F11/0074 ,  B01F11/0071 ,  B01L3/0275 ,  G01N35/10 ,  G01N2035/1058 ,  G01N2035/106 ,  G01N2035/1062

摘要： Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used to provide agglutination of blood, which in turn can be used for blood typing. The probe tip can comprise a single integral piece, or two separate portions. The transition zone can comprise a sharp demarcation between inside diameters, or a smooth one.

摘要翻译： 用于将液体混合在一次性吸入探针尖端内的装置和方法，使得大部分液体被迫移动经过两个不同内径之间的过渡区域以引起旋转混合。 该装置和方法可以用于提供血液的凝集，这又可以用于血液分型。 探针尖端可以包括单个整体件或两个单独的部分。 过渡区域可以包括内径之间的锐利分界，或平滑的。