公开(公告)号：EP2282778A2

公开(公告)日：2011-02-16

申请号：EP09738185.9

申请日：2009-04-29

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei ,  GUERASSIMENKO, Oxana ,  GRAUDENS, Esther

IPC分类号： A61K45/06 ,  A61P25/28

CPC分类号： A61K31/55 ,  A61K31/155 ,  A61K31/195 ,  A61K31/37 ,  A61K31/42 ,  A61K31/4365 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease. In a preferred embodiment, the invention relates to a composition comprising a combination of at least two compounds chosen from the group consisting a leflunomide, sulf isoxazole, terbinafine, baclofen, clopidogrel, fenoldopam, mepacrine and phenformin, or salts or prodrugs or derivatives or sustained release formulations thereof, for simultaneous, separate or sequential administration.

公开(公告)号：EP3797767A1

公开(公告)日：2021-03-31

申请号：EP20206600.7

申请日：2010-10-29

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei

IPC分类号： A61K31/197 ,  A61P25/28

摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder.

公开(公告)号：EP2496226B1

公开(公告)日：2020-03-04

申请号：EP10773302.4

申请日：2010-10-29

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei

IPC分类号： A61K31/137 ,  A61K31/155 ,  A61K31/167 ,  A61K31/185 ,  A61K31/343 ,  A61K31/423 ,  A61K31/4985 ,  A61P25/28 ,  A61K31/195

公开(公告)号：EP3560496A1

公开(公告)日：2019-10-30

申请号：EP19174818.5

申请日：2009-04-29

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei ,  GUERASSIMENKO, Oxana ,  CHOLET, Nathalie

IPC分类号： A61K31/42 ,  A61K31/255 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate synapse function for treating said disease.

公开(公告)号：EP3003268B1

公开(公告)日：2018-07-25

申请号：EP14727848.5

申请日：2014-06-05

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei ,  BERTRAND, Viviane

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/7004 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K31/19 ,  A61K31/485

CPC分类号： A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K31/047 ,  A61K31/195 ,  A61K31/197 ,  A61K31/485 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K2300/00

摘要： The present invention relates to a homogeneous, stable, and palatable pharmaceutical solution comprising baclofen, sorbitol and naltrexone.

公开(公告)号：EP2892518B1

公开(公告)日：2018-07-11

申请号：EP13759492.5

申请日：2013-09-04

申请人： Pharnext

发明人： COHEN, Daniel ,  NABIROCHKIN, Serguei ,  CHUMAKOV, Ilya

IPC分类号： A61K31/185 ,  A61K31/195 ,  A61K31/421 ,  A61K31/197 ,  A61K31/137 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/19 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/155 ,  A61K31/138 ,  A61K31/506 ,  A61K31/4422 ,  A61K31/64 ,  A61K31/519 ,  A61K31/222 ,  A61K45/06 ,  A61P25/16

CPC分类号： A61K31/519 ,  A61K31/13 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/165 ,  A61K31/185 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/24 ,  A61K31/27 ,  A61K31/343 ,  A61K31/353 ,  A61K31/403 ,  A61K31/4045 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4422 ,  A61K31/445 ,  A61K31/4458 ,  A61K31/4525 ,  A61K31/48 ,  A61K31/485 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

公开(公告)号：EP3254682A1

公开(公告)日：2017-12-13

申请号：EP17179482.9

申请日：2013-02-28

申请人： Pharnext

发明人： COHEN, Daniel ,  NABIROCHKIN, Serguei ,  CHUMAKOV, Ilya ,  HAJJ, Rodolphe

IPC分类号： A61K31/44 ,  A61K31/195 ,  A61K31/185 ,  A61P25/16

CPC分类号： A61K31/519 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/185 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4422 ,  A61K31/445 ,  A61K31/506 ,  A61K45/06 ,  A61K31/24 ,  A61K2300/00 ,  A61K31/64 ,  A61K31/48 ,  A61K31/428 ,  A61K31/4045 ,  A61K31/485 ,  A61K31/135 ,  A61K31/165 ,  A61K31/5513 ,  A61K31/551 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/13 ,  A61K31/27 ,  A61K31/353 ,  A61K31/55 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4458 ,  A61K31/505 ,  A61K31/4184

摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

公开(公告)号：EP3185859A1

公开(公告)日：2017-07-05

申请号：EP15762523.7

申请日：2015-08-28

申请人： Pharnext

发明人： COHEN, Daniel ,  NABIROCHKIN, Serguei ,  CHUMAKOV, Ilya ,  HAJJ, Rodolphe

IPC分类号： A61K31/137 ,  A61K31/4985 ,  A61P25/16

CPC分类号： A61K31/137 ,  A61K9/0053 ,  A61K31/135 ,  A61K31/138 ,  A61K31/165 ,  A61K31/185 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/44 ,  A61K31/4985 ,  A61K45/06 ,  A61K2300/00 ,  A61P25/16

摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

公开(公告)号：EP3038614A1

公开(公告)日：2016-07-06

申请号：EP14759137.4

申请日：2014-09-01

申请人： Pharnext

发明人： COHEN, Daniel ,  CHUMAKOV, Ilya ,  NABIROCHKIN, Serguei ,  GUEDJ, Mickael ,  VIAL, Emmanuel

IPC分类号： A61K31/195 ,  A61K31/197 ,  A61K31/44 ,  A61K31/185 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28

CPC分类号： A61K31/585 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/167 ,  A61K31/185 ,  A61K31/197 ,  A61K31/28 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/423 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/48 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/50 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.

摘要翻译： 本发明涉及用于治疗与谷氨酸兴奋毒性和淀粉样蛋白β毒性相关的神经障碍的组合物和方法。 更具体地说，本发明涉及多发性硬化，阿尔茨海默病，阿尔茨海默病相关疾病，肌萎缩性侧索硬化，帕金森病，亨廷顿病，神经性疼痛，酒精神经病，酒精中毒或酒精戒断或脊髓损伤的新型组合疗法。

公开(公告)号：EP2892518A2

公开(公告)日：2015-07-15

申请号：EP13759492.5

申请日：2013-09-04

申请人： Pharnext

发明人： COHEN, Daniel ,  NABIROCHKIN, Serguei ,  CHUMAKOV, Ilya

IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/165 ,  A61K31/185 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/24 ,  A61K31/27 ,  A61K31/343 ,  A61K31/353 ,  A61K31/403

CPC分类号： A61K31/519 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/185 ,  A61K31/192 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4422 ,  A61K31/445 ,  A61K31/506 ,  A61K45/06 ,  A61K31/24 ,  A61K2300/00 ,  A61K31/64 ,  A61K31/48 ,  A61K31/428 ,  A61K31/4045 ,  A61K31/485 ,  A61K31/135 ,  A61K31/165 ,  A61K31/5513 ,  A61K31/551 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/13 ,  A61K31/27 ,  A61K31/353 ,  A61K31/55 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4458 ,  A61K31/505 ,  A61K31/4184

摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.