公开(公告)号：EP4311833A3

公开(公告)日：2024-05-01

申请号：EP23193595.8

申请日：2012-10-26

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew J. ,  GURER, Cagan ,  MCWHIRTER, John ,  VORONINA, Vera ,  HARRIS, Faith ,  STEVENS, Sean

IPC分类号： A01K67/027 ,  C07K14/705 ,  C07K14/74

CPC分类号： C07K14/70539 ,  A01K2217/07220130101 ,  A01K2217/1520130101 ,  A01K2227/10520130101 ,  A01K2267/0320130101 ,  A01K67/0278

摘要： The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized beta2 microglobulin polypeptide, as well as non-human embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

公开(公告)号：EP4249507A2

公开(公告)日：2023-09-27

申请号：EP23175859.0

申请日：2014-03-11

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew, J. ,  TU, Naxin ,  GURER, Cagan ,  VORONINA, Vera ,  STEVENS, Sean

IPC分类号： C07K14/74

摘要： The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

公开(公告)号：EP2770822B9

公开(公告)日：2019-12-11

申请号：EP12806199.1

申请日：2012-10-26

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew J. ,  TU, Naxin ,  GURER, Cagan ,  VORONINA, Vera ,  STEVENS, Sean

IPC分类号： A01K67/027 ,  C07K14/705

公开(公告)号：EP2958938B1

公开(公告)日：2019-04-17

申请号：EP14708430.5

申请日：2014-02-20

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew, J. ,  TU, Naxin ,  VORONINA, Vera ,  GURER, Cagan

IPC分类号： C07K14/73 ,  C07K14/705 ,  C12N15/85 ,  A01K67/027

公开(公告)号：EP3456832A1

公开(公告)日：2019-03-20

申请号：EP18202954.6

申请日：2011-06-22

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  STEVENS, Sean ,  GURER, Cagan ,  MURPHY, Andrew J. ,  HOSIAWA, Karolina A.

IPC分类号： C12N15/85 ,  A01K67/027 ,  C07K16/00 ,  C07K16/46 ,  C07K16/18 ,  C12N15/10

摘要： Genetically modified mice are provided that express human λ variable (hVλ,) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ, sequences from an endogenous mouse κ light chain locus, and mice that express hVλ, sequences from a transgene or an episome wherein the hVλ, sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.

公开(公告)号：EP3421490A1

公开(公告)日：2019-01-02

申请号：EP18182319.6

申请日：2014-02-20

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew J. ,  VORONINA, Vera ,  GURER, Cagan

IPC分类号： C07K14/73 ,  C07K14/705 ,  C12N15/85 ,  A01K67/027 ,  C07K14/74

摘要： The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized 2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

公开(公告)号：EP3086637B1

公开(公告)日：2019-01-02

申请号：EP15813960.0

申请日：2015-11-25

申请人： Regeneron Pharmaceuticals, Inc.

发明人： GURER, Cagan ,  IOFFE, Ella ,  MUJICA, Alexander ,  THURSTON, Gavin

IPC分类号： A01K67/027 ,  C07K14/705 ,  C07K16/28 ,  C12N15/85 ,  G01N33/50

公开(公告)号：EP3409110A1

公开(公告)日：2018-12-05

申请号：EP18185303.7

申请日：2014-11-10

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MCWHIRTER, John ,  GURER, Cagan ,  MACDONALD, Lynn ,  MURPHY, Andrew J.

IPC分类号： A01K67/027 ,  C07K14/54 ,  C07K14/705

CPC分类号： A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/07 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0325 ,  A01K2267/0381 ,  A01K2267/0387 ,  C07K14/70575 ,  C07K2319/00 ,  G01N33/5088 ,  G01N2500/10

摘要： Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized B-cell activating factor gene. Non-human animals and cells that express a human or humanized B-cell activating factor protein from an endogenous B-cell activating factor locus are described.

公开(公告)号：EP3071024B1

公开(公告)日：2018-09-05

申请号：EP14803022.4

申请日：2014-11-10

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MCWHIRTER, John ,  GURER, Cagan ,  MACDONALD, Lynn ,  MURPHY, Andrew J.

IPC分类号： A01K67/027 ,  C07K14/54 ,  C07K14/705

CPC分类号： A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/07 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0325 ,  A01K2267/0381 ,  A01K2267/0387 ,  C07K14/70575 ,  C07K2319/00 ,  G01N33/5088 ,  G01N2500/10

摘要： Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized B-cell activating factor gene. Non-human animals and cells that express a human or humanized B-cell activating factor protein from an endogenous B-cell activating factor locus are described.

公开(公告)号：EP2770821B1

公开(公告)日：2017-09-13

申请号：EP12787255.4

申请日：2012-10-26

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MACDONALD, Lynn ,  MURPHY, Andrew, J. ,  GURER, Cagan ,  MCWHIRTER, John ,  VORONINA, Vera ,  HARRIS, Faith ,  STEVENS, Sean

IPC分类号： C07K14/74 ,  A01K67/027

CPC分类号： A01K67/0278 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/70539