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38 条记录 (耗时 0.026 秒)

    Extended release of neuregulin for improved cardiac function
    31.
    发明公开
    Extended release of neuregulin for improved cardiac function 有权
    VerlängerteFreisetzung von Neuregulinfürverbesserte Harzfunktion

    公开(公告)号：EP2918283A1

    公开(公告)日：2015-09-16

    申请号：EP15151306.6

    申请日：2006-12-29

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： Zhou, Mingdong

    IPC分类号： A61K38/17 ,  C07K14/475 ,  A61P9/00

    CPC分类号： A61K38/1883 ,  A61K9/0019 ,  A61K9/127 ,  A61K47/60 ,  A61K48/00

    摘要： The invention provides Neuregulin or a functional fragment thereof for use in a method of preventing, treating or delaying heart failure or preventing cardiac hypertrophy in a mammal, wherein the method comprises releasing Neuregulin to the mammal over a period of 4 hours or longer per day by extended release means such as an osmotic pump, a syringe pump, packaging into a liposome or microsphere or coupling to a polymer.

    摘要翻译： 本发明提供了用于预防，治疗或延缓心力衰竭或预防哺乳动物心脏肥大的方法的神经调节蛋白或其功能片段，其中所述方法包括通过每天4小时或更长时间向哺乳动物释放神经调节蛋白 延长释放装置如渗透泵，注射泵，包装成脂质体或微球体或与聚合物偶联。

    Neuregulin peptides and their use
    33.
    发明公开
    Neuregulin peptides and their use 有权
    神经调节蛋白肽及其使用

    公开(公告)号：EP2808339A1

    公开(公告)日：2014-12-03

    申请号：EP14168475.3

    申请日：2009-11-09

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： Zhou, Mingdong

    IPC分类号： C07K14/475 ,  A61K38/18 ,  A61P9/10

    CPC分类号： C07K14/4756 ,  A61K38/00 ,  A61K38/16 ,  A61K38/1883 ,  C07K14/00

    摘要： The present invention relates to a neuregulin peptide consisting essentially of or consisting of the amino acid sequence selected from the group consisting of SEQ ID NO:9, SEQ ID NO:3, SEQ ID NO:7 and SEQ ID NO:5 as specified herein. The present invention further relates to a pharmaceutical composition comprising the said neuregulin peptide and a pharmaceutically acceptable carrier, excipient, or diluent. The present invention also relates to the said neuregulin peptide for use in a method of treating heart failure in a subject.

    Neukinase, a downstream protein of neuregulin
    35.
    发明公开
    Neukinase, a downstream protein of neuregulin 有权
    Neuregulin是神经调节蛋白的下游蛋白

    公开(公告)号：EP2730654A2

    公开(公告)日：2014-05-14

    申请号：EP13184566.1

    申请日：2007-08-21

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： Zhou, Mingdong

    IPC分类号： C12N15/11 ,  C12N15/12 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N9/48 ,  C12N5/16 ,  C12N5/22 ,  C07H21/00 ,  C07K16/16 ,  A61K38/45 ,  C07K16/40 ,  C12Q1/48 ,  G01N33/68 ,  C12N9/12

    CPC分类号： C07K16/40 ,  A61K38/45 ,  C12N9/1205 ,  C12Q1/485 ,  G01N33/68 ,  G01N33/6842 ,  G01N2333/4756

    摘要： The present invention relates to an isolated polypeptide comprising an amino acid sequence having at least 70% identity to the amino acid sequence of SEQ ID NO:2 or to the amino acid sequence of SEQ ID NO:25; or encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or the amino acid sequence of SEQ ID NO: 25, wherein the polypeptide is capable of phosphorylating myosin light chain. The present invention also relates to an isolated nucleic acid encoding said polypeptide; a composition and a kit comprising the polypeptide or the nucleic acid; a vector comprising the isolated nucleic acid; an isolated host cell comprising the nucleic acid or the vector; an antibody that specifically binds to the polypeptide of the present invention; and a transgenic non-human animal which expresses the nucleic acid of the present invention. The invention further relates to a method of detecting the presence of a nucleic acid of the present invention; and a method of producing a neukinase polypeptide of the present invention.

    摘要翻译： 本发明涉及分离的多肽，其包含与SEQ ID NO：2的氨基酸序列或SEQ ID NO：25的氨基酸序列具有至少70％同一性的氨基酸序列; 或编码包含SEQ ID NO：2的氨基酸序列或SEQ ID NO：25的氨基酸序列的多肽，其中所述多肽能够磷酸化肌球蛋白轻链。 本发明还涉及编码所述多肽的分离的核酸; 包含所述多肽或所述核酸的组合物和试剂盒; 包含分离的核酸的载体; 包含核酸或载体的分离的宿主细胞; 特异性结合本发明多肽的抗体; 和表达本发明核酸的转基因非人动物。 本发明进一步涉及检测本发明核酸存在的方法; 以及生产本发明的新生素酶多肽的方法。