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274 条记录 (耗时 0.016 秒)

    APPARATUS AND PROCESS FOR PREPARING CRYSTALLINE PARTICLES
    32.
    发明授权
    APPARATUS AND PROCESS FOR PREPARING CRYSTALLINE PARTICLES 有权
    设备和生产结晶粒子的制造方法

    公开(公告)号：EP1225875B1

    公开(公告)日：2004-07-28

    申请号：EP00973049.0

    申请日：2000-11-03

    申请人： GLAXO GROUP LIMITED

    发明人： FERRIE, Alan, Ronald ,  SAVAGE, Andrew, Patrick

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/00

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/1688 ,  B01D9/005 ,  B01D9/0059 ,  B01F3/08 ,  B01F5/0057

    摘要： An apparatus for preparing crystalline particles of a substance suitable for inhalation therapy comprises (i) a first reservoir 3 of said substance dissolved in a liquid solvent; (ii) a second reservoir 3 of liquid antisolvent for said substance which is miscible with the liquid solvent; (iii) a cylindrical mixing chamber 2 having first and second tangential inlet ports and an axial outlet port; (iv) means for delivering the contents of the first and second reservoirs to the mixing chamber in a stream via the first and second inlet ports respectively at independent controlled flow rate, the streams of liquid from t he i nlet a nd o utlet ports being intimately mixed in the cylindrical mixing chamber through formation of a vortex thereby causing precipitation of crystalline particles of the substance; and (vi) means 5 for collecting crystalline particles suspended in the stream of liquid discharged from the outlet port of the mixing chamber.

    METHOD FOR THE PRODUCTION OF PARTICLES
    36.
    发明公开
    METHOD FOR THE PRODUCTION OF PARTICLES 有权
    用于生产颗粒

    公开(公告)号：EP1232002A1

    公开(公告)日：2002-08-21

    申请号：EP00976138.8

    申请日：2000-11-15

    申请人： ADVANCED PHYTONICS LIMITED

    发明人： NICOLA, Mazin

    IPC分类号： B01J2/02

    CPC分类号： B01J2/02 ,  B01D9/0027 ,  B01D9/005

    摘要： A method of preparing particles of a substance, for example selected from a flavor, fragrance, pigment, dye, biologically active compound or a plastics material, comprises contacting the substance of a formulation (which may include the substance in conjunction with a second solvent) with a first solvent which comprises a C1-C4 hydrofluorocarbon, especially tetrafluoroethane, and subjecting the resultant mixture to a separation process, for example, by allowing the mixture to be sprayed as a mist ( 14 ) from a high pressure environment in a first vessel ( 2 ) to a low pressure environment in a second vessel ( 8 ), thereby to cause separation of a least some of the substance from the first solvent and the formation of fine particles ( 20 ) of the substance.

    FRACTIONATION OF TRIGLYCERIDE OILS
    38.
    发明公开
    FRACTIONATION OF TRIGLYCERIDE OILS 失效
    TRIGLYCERIDOELFRAKTIONIERUNG

    公开(公告)号：EP0711334A1

    公开(公告)日：1996-05-15

    申请号：EP94925370.0

    申请日：1994-07-19

    申请人： UNILEVER PLC ,  UNILEVER N.V.

    发明人： SMITH, Paul Raymond ,  VAN DEN KOMMER, Marcelle

    IPC分类号： A23D9 ,  A23J7 ,  B01D9 ,  C11B7

    CPC分类号： A23D9/007 ,  A23J7/00 ,  B01D9/005 ,  C11B7/0083

    摘要： Triglyceride oil crystallisation modifying substance being membrane lipids which are comprised by the groups (I) lipids having the formula C13H27-CH=CH-CH(OH)-CH(NHCOR2)-CH2-OR4, C13H27- is an unbranched alkyl chain, R4 is hydrogen or R3; (II) lipids having formula (a) including the corresponding lysophosphatides where one of the ester groups have been hydrolysed; (III) lipids having formula (b) where R1 and R2 are unbranched (C1-C24)-hydrocarbon chains, provided at least one of R1 and R2 is a (C8-C24)-hydrocarbon chain, P is a phosphoryl moiety, which comprises phosphoryl serine, phosphoryl ethanolamine, phosphoryl choline, disphosphoryl glycerol and phosphoryl inositol according to figures (5 - 9) respectively and where R3 is a sugar moiety which comprises a monosaccharide residue, a disaccharide residue or an oligosaccharide residue, including glucose, fructose, galactose, saccharose, lactose and maltose residues; (IV) a sphingomyelin according to figure (1); (V) a cerebroside according to figure (3), where [S] is a sugar moiety chosen from the group comprising a monosaccharide residue, a disaccharide residue or an oligosaccharide residue, including glucose, fructose, galactose, saccharose, lactose and maltose residues; (VI) mixtures of lipids taken from groups (I - V). When in a crystallising oil a membrane lipid is present, a higher separation efficiency of the stearin phase from the crystallised oil can be accomplished.

    METHOD AND APPARATUS FOR THE CONTROL OF SOLIDIFICATION IN LIQUIDS
    39.
    发明公开
    METHOD AND APPARATUS FOR THE CONTROL OF SOLIDIFICATION IN LIQUIDS 无效
    方法和设备，用于控制液体凝固。

    公开(公告)号：EP0584127A1

    公开(公告)日：1994-03-02

    申请号：EP92909566.0

    申请日：1992-05-05

    申请人： ACTON, Elizabeth ,  MORRIS, George John

    发明人： ACTON, Elizabeth ,  MORRIS, George John

    IPC分类号： A23D7 ,  A23D9 ,  A23G1 ,  A23G3 ,  A23G9 ,  A23L3 ,  B01D9

    CPC分类号： B01D9/005 ,  A23D7/05 ,  A23D9/02 ,  A23G1/18 ,  A23G3/0226 ,  A23G9/04 ,  A23G9/08 ,  A23G9/14 ,  A23L3/30 ,  A23L3/36 ,  B01D9/04

    摘要： Procédé de solidification d'un liquide consistant à faire descendre la température du liquide en-dessous de son point de congélation et à soumettre le liquide à une perturbation physique, de préférence à irradier le liquide surrefroidi ou partiellement solidifié avec des ultrasons pour maîtriser la nucléation et/ou la cristallogénèse. La fréquence préférée pour les ultrasons est comprise dans la plage 16-100 kHz. La fréquence idéale étant de 20-40 kHz. Selon un mode de réalisation de la présente invention, les liquides surrefroidis sont irradiés à une température pouvant aller jusqu'à 1 °C en-dessous de leur point de congélation pour induire la formation de gros cristaux (500 microns) dans le produit solidifié. Selon un autre mode de réalisation, les liquides partiellement solidifiés sont irradiés à une température plus basse que leur point de congélation de façon à induire la formation de plusieurs petits cristaux (50 microns) dans le produit solidifié. Les dispositifs servant à mettre en oeuvre les procédés présentés sont également décrits.