-
公开(公告)号：EP2984172B1
公开(公告)日：2018-08-22
申请号：EP14721468.8
申请日：2014-04-10
IPC分类号： C12N15/864 , C07K14/47 , C12N15/113 , C12N9/16 , A61K48/00 , C12N15/86 , A61K38/46 , A61K38/48 , C12N9/64
CPC分类号： A61K48/0066 , A61K38/465 , A61K38/4873 , A61K48/0058 , A61K48/0075 , C07K14/4707 , C12N9/16 , C12N9/6472 , C12N15/86 , C12N2750/14132 , C12N2750/14143 , C12N2830/008 , C12Y301/03048 , C12Y304/22054
-
公开(公告)号：EP2751257B1
公开(公告)日：2018-06-27
申请号：EP12831715.3
申请日：2012-09-14
CPC分类号： C07K14/4705 , A61K38/00 , A61K38/1709 , A61K45/06 , A61K48/00 , C07K14/4702 , C07K14/4707 , C07K14/4708 , C12N5/0659 , C12N7/00 , C12N2501/415 , C12N2533/52 , C12N2710/10042 , C12N2740/10042 , C12N2740/15042
摘要： There are provided compositions and methods for modulating stem cell division, in particular, division symmetry. It has been demonstrated that Wnt7a polypeptide fragments promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro, ex vivo, and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.
-
33.发明公开
公开(公告)号：EP3332796A1
公开(公告)日：2018-06-13
申请号：EP17199335.5
申请日：2010-11-17
发明人： SEEHRA, Jasbir , LACHEY, Jennifer
CPC分类号： C07K14/4707 , A61K38/1709 , A61P21/00 , C07K14/4708 , C07K16/26 , C07K16/2869 , C07K2317/76
摘要： In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand.
-
公开(公告)号：EP3262065A1
公开(公告)日：2018-01-03
申请号：EP16756450.9
申请日：2016-02-26
申请人： The Charlotte-Mecklenburg Hospital Authority D/B/A , The University of North Carolina at Chapel Hill
发明人： LU, Qi Long , XIAO, Xiao
CPC分类号： A61K48/0058 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A61K38/00 , A61K38/1719 , C07K14/4707 , C12N9/10 , C12N15/86 , C12N2750/14143 , C12N2800/22 , C12N2830/008
摘要： The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.
-
35.发明授权COMPOSITIONS AND METHODS FOR DELIVERY OF PROTEIN-CODING RNAS TO CORRECT MITOCHONDRIAL DYSFUNCTION 有权组合物和方法喂养蛋白质编码RNA来纠正AN线粒体MALFUNCTION
公开(公告)号：EP2329023B1
公开(公告)日：2016-07-27
申请号：EP09786186.8
申请日：2009-08-28
发明人： ADHYA, Samit
IPC分类号： C12N15/11 , C12N15/63 , C12N15/30 , C07K14/44 , C07K14/47 , C12N5/10 , A61K38/16 , A61K48/00
CPC分类号： C07K14/4707 , A61K48/0008 , A61K48/0025 , A61K48/005 , C07K2319/07 , C12N2810/10
-
公开(公告)号：EP2861738A4
公开(公告)日：2015-12-23
申请号：EP13807865
申请日：2013-06-18
申请人： HUTCHINSON FRED CANCER RES , UNIV LEIDEN MEDICAL CT , UNIV ROCHESTER MEDICAL CT , UNIV WASHINGTON CT COMMERCIALI
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4707 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6887 , G01N2333/4712 , G01N2800/10 , C12N2310/531
-
37.发明公开ACTRIIB PROTEINS AND VARIANTS AND USES THEREFORE RELATING TO UTROPHIN INDUCTION FOR MUSCULAR DYSTROPHY THERAPY 有权的ActRIIB蛋白及其变体和他们的疗法反对肌营养不良应用程序中的utrophin感应
公开(公告)号：EP2501400A4
公开(公告)日：2013-06-19
申请号：EP10832122
申请日：2010-11-17
申请人： ACCELERON PHARMA INC
发明人： SEEHRA JASBIR , LACHEY JENNIFER
IPC分类号： A61K38/18
CPC分类号： C07K14/4707 , A61K38/1709 , C07K14/4708 , C07K16/26 , C07K16/2869 , C07K2317/76
摘要： In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand.
摘要翻译： 在某些方面，本发明提供组合物和方法在蛋白质的ActRIIB诱导肌肉肌养相关蛋白的表达与作为治疗肌营养不良。 因此，本发明提供了筛选化合物的方法做了调节配体的活性的ActRIIB蛋白和/或到的ActRIIB。
-
38.发明公开COMPOSITIONS AND METHODS FOR DELIVERY OF PROTEIN-CODING RNAS TO CORRECT MITOCHONDRIAL DYSFUNCTION 有权组合物和方法喂养蛋白质编码RNA来纠正AN线粒体MALFUNCTION
公开(公告)号：EP2329023A1
公开(公告)日：2011-06-08
申请号：EP09786186.8
申请日：2009-08-28
发明人： ADHYA, Samit
IPC分类号： C12N15/11 , C12N15/63 , C12N15/30 , C07K14/44 , C07K14/47 , C12N5/10 , A61K38/16 , A61K48/00
CPC分类号： C07K14/4707 , A61K48/0008 , A61K48/0025 , A61K48/005 , C07K2319/07 , C12N2810/10
摘要： The present invention provides compositions and methods for using correctional RNA, with a proteinaceous carrier, to stimulate respiration of the cells, tissues, organs or the whole organism of normal or diseased subjects. In one embodiment of the invention, the signal-tagged correctional RNA is one or more protein-coding RNAs (pcRNA) that encode one or more of human mitochondrial proteins. The invention specifically provides a broad-spectrum formulation applicable to a wide variety of disorders that are associated with mitochondrial mutations.
-
39.发明公开NUCLEIC ACID CODIFYING FOR A UTROPHIN TRANSCRIPTION SPECIFIC REGULATING PROTEIN, PROTEIN CODIFIED THEREBY AND USES THEREOF 有权FOR A UTROPHINTRANSKRIPTIONSSPEZIFISCHES调节蛋白编码核酸的SO CODED蛋白和使用
公开(公告)号：EP2193200A1
公开(公告)日：2010-06-09
申请号：EP08807901.7
申请日：2008-10-06
CPC分类号： C07K14/4707
摘要： The present invention relates to a nucleic acid molecule comprising a nucleotide sequence codifying for a protein characterized in having at least four zinc finger domains and in modulating the transcription of the utrophin gene by binding to a nucleotidic sequence comprised in a utrophin gene untranscribed regulatory sequence. Protein codified thereby and uses thereof.
-
40.发明公开
公开(公告)号：EP0862644A2
公开(公告)日：1998-09-09
申请号：EP96945991.0
申请日：1996-11-14
CPC分类号： C12N15/86 , A61K48/00 , C07K14/4707 , C07K14/70571 , C12N9/0075 , C12N2710/10343
摘要： The invention relates to a gene-therapeutic nucleic acid construct containing a regulatory nucleic acid sequence of the 5´-end of the myosin light chain 2 (MLC-2) heart gene. The regulatory nucleic acid sequence in question is functionally connected to a nucleic acid which codes for a therapeutically active gene product, antisense nucleic acid or ribozyme. Also disclosed is a process for producing the construct and its use in gene therapy for treating heart disorders.
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.028 秒)
