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31.发明公开
公开(公告)号：EP2327764A1
公开(公告)日：2011-06-01
申请号：EP09075536.4
申请日：2009-11-30
CPC分类号： C12N7/00 , A61K35/768 , A61K45/06 , C12N2760/18121 , C12N2760/18132
摘要： A new clone of Newcastle disease virus is described which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases.
摘要翻译： 新城疫病毒的一种新的克隆所描述的所有它是干扰素不敏感，并且具有到ICPI可以以癌症和其它疾病的治疗中使用1.2和2.0之间并且。
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32.发明公开Compositions for treating cancer using viruses 失效Zusammensetzungen zur Behandlung von Krebs mittels Viren
公开(公告)号：EP2009119A1
公开(公告)日：2008-12-31
申请号：EP08166836.0
申请日：1994-04-29
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/768 , A61K39/12 , A61K39/17 , C12N2760/18132 , C12Q1/70 , A61K2300/00
摘要： The invention provides compositions for treating cancer in a mammal comprising an effective amount of a Newcastle Disease Virus. The invention also provides a composition for treating cancer in a mammal comprising a Newcastle Disease Virus in combination with another agent such as a chemotherapeutic compound, a cytokine, an immunosuppressive agent, or an antibody.
摘要翻译： 本发明提供用于治疗哺乳动物中癌症的组合物，其包含有效量的新城疫病毒。 本发明还提供了用于治疗哺乳动物癌症的组合物，其包含与另一种药剂如化学治疗化合物，细胞因子，免疫抑制剂或抗体组合的新城疫病毒。
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33.发明公开
公开(公告)号：EP1907015A2
公开(公告)日：2008-04-09
申请号：EP06774644.6
申请日：2006-07-12
CPC分类号： A61K45/06 , A61K31/4745 , A61K35/76 , C12N2760/18132 , A61K2300/00
摘要： Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.
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公开(公告)号：EP1744780A2
公开(公告)日：2007-01-24
申请号：EP05779961.1
申请日：2005-04-26
IPC分类号： A61K39/385 , A61K39/12
CPC分类号： A61K35/768 , A61K31/4745 , A61K39/39558 , A61K45/06 , C12N2760/18132 , Y02A50/466 , A61K2300/00
摘要： Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.
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公开(公告)号：EP1385466A4
公开(公告)日：2005-10-12
申请号：EP02725980
申请日：2002-05-09
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
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公开(公告)号：EP1314431A3
公开(公告)日：2003-06-18
申请号：EP02026340.6
申请日：1994-04-29
IPC分类号： A61K35/76
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/768 , A61K39/12 , A61K39/17 , C12N2760/18132 , C12Q1/70 , A61K2300/00
摘要： The invention provides compositions for treating cancer in a mammal comprising an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides a composition for treating cancer in a mammal comprising such viruses in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, cytokine, or immunosuppressive agent.
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公开(公告)号：EP0696326B1
公开(公告)日：2003-04-02
申请号：EP94916604.5
申请日：1994-04-29
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/768 , A61K39/12 , A61K39/17 , C12N2760/18132 , C12Q1/70 , A61K2300/00
摘要： The invention provides compositions for treating cancer in a mammal comprising an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides a composition for treating cancer in a mammal comprising such viruses in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, cytokine, or immunosuppressive agent.
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公开(公告)号：EP1032269A4
公开(公告)日：2001-09-19
申请号：EP98949797
申请日：1998-10-09
申请人： PRO VIRUS INC
IPC分类号： G01N33/50 , A61K35/76 , A61K38/21 , A61K39/42 , A61K48/00 , A61P35/00 , C12N7/00 , C12N7/04 , C12N15/00 , C12N15/01 , G01N33/15 , A01N63/00 , C12N7/02
CPC分类号： C12N7/00 , A61K35/768 , A61K38/21 , A61K39/42 , C12N2760/18132 , C12N2760/18151 , G01N33/5011 , G01N2500/10 , G01N2800/7028 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumours. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
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39.发明授权
公开(公告)号：EP3041490B1
公开(公告)日：2018-11-14
申请号：EP14761317.8
申请日：2014-09-02
申请人： Medimmune Limited
发明人： CHENG, Xing , CARROLL, Danielle , MCCOURT, Matthew , GALINSKI, Mark , JIN, Hong
IPC分类号： A61K35/76 , A61K35/768 , C07K14/005 , C07K14/535 , C12N15/86 , C12N7/00
CPC分类号： C12N7/00 , A61K35/768 , C07K14/005 , C07K14/535 , C12N15/86 , C12N2710/16122 , C12N2710/16143 , C12N2760/18122 , C12N2760/18132 , C12N2760/18133 , C12N2760/18143
摘要： The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.
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40.发明公开COMPOSITIONS FEATURING AN ATTENUATED NEWCASTLE DISEASE VIRUS AND METHODS OF USE FOR TREATING NEOPLASIA 审中-公开以较慢的用于治疗肿瘤的治疗克罗恩纽卡斯尔病毒和方法组成
公开(公告)号：EP3041490A1
公开(公告)日：2016-07-13
申请号：EP14761317.8
申请日：2014-09-02
申请人： Medimmune Limited
发明人： CHENG, Xing , CARROLL, Danielle , MCCOURT, Matthew , GALINSKI, Mark , JIN, Hong
IPC分类号： A61K35/76 , C07K14/535 , C12N15/86
CPC分类号： C12N7/00 , A61K35/768 , C07K14/005 , C07K14/535 , C12N15/86 , C12N2710/16122 , C12N2710/16143 , C12N2760/18122 , C12N2760/18132 , C12N2760/18133 , C12N2760/18143
摘要： The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.
摘要翻译： 本发明提供了用于诱导在人受试者中肿瘤的消退的方法，该方法利用新城疫病毒（NDV）的具有修饰的F蛋白切割位点的修饰的中等毒力株，所有这些是不致病的家禽（轻型），但展品溶瘤属性 ， 盘方法游离缺失提供安全，有效和可靠的手段以诱导肿瘤的消退在需要其的个体。 这些方法克服了使用病毒致病菌株为人类治疗的缺点。
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