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64 条记录 (耗时 0.015 秒)

    Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
    31.
    发明公开
    Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents 失效
    4,5-二（羟甲基）-2-氧代-1,3-二氧杂环戊烯 - 双 - 酯作为抗菌药。

    公开(公告)号：EP0102226A1

    公开(公告)日：1984-03-07

    申请号：EP83304801.0

    申请日：1983-08-19

    申请人： PFIZER INC.

    发明人： Welch, Willard McKowan

    IPC分类号： C07D519/00 ,  C07D499/32 ,  A61K31/43

    CPC分类号： C07D499/00 ,  C07D317/40

    摘要： Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been esterified through the carboxy group of sulbactam (penicillanic acid 1,1-dioxide), are useful as antibacterial agents. Certain novel compounds, which are useful as intermediates to the aforesaid antibacterial agents, are also disclosed.

    Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
    34.
    发明公开
    Process and intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates 失效
    Verfahren und Zwischenprodukte zur Herstellung von 1,1-二氧代 - 青霉烷酰氧基甲基-6-（2-氨基-2-苯乙酰氨基）青霉烷。

    公开(公告)号：EP0061274A1

    公开(公告)日：1982-09-29

    申请号：EP82301296.8

    申请日：1982-03-15

    申请人： PFIZER INC.

    发明人： Jasys, Vytautas John

    IPC分类号： C07D519/00 ,  C07D499/32 ,  C07D499/00

    CPC分类号： C07D499/00

    摘要： Compounds of the formula
    wherein R 1 is H or HO; Y and Z are each Cl, Br or I, or Y is H and Z is Cl, Br or I; Q is N 3 or NHCO 2 CH 2 C 6 H 4 R 4 where R 4 is H, Cl, Br, N0 2 , CH 3 or OCH 3 ; a process for their use in production of the valuable antibacterial agents 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenyl- acetamido)penicillanate and 1,1-dioxopenicillanoyloxymethyl 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-penicillanate, by catalytic hydrogenation in the presence of a noble metal catalyst and novel intermediates useful in preparing said compounds of formula (1).

    摘要翻译： 式CHEM的化合物，其中R 1是H或HO; Y和Z各自为Cl，Br或I，或Y为H，Z为Cl，Br或I; Q是N 3或NHCO 2 CH 2 C 6 H 4 R 4，其中R 4是H，Cl，Br，NO 2，CH 3或OCH 3; 它们用于生产有价值的抗菌剂6-（2-氨基-2-苯基乙酰氨基）青霉素的1,1-二氧代青霉酰氨基甲酰基和6- [2-氨基-2-（对羟基苯基）乙酰氨基的1,1-二氧代青霉烷酰氧基甲基 ]青霉烷，在贵金属催化剂存在下通过催化氢化和用于制备所述式（I）化合物的新型中间体。

    1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof
    37.
    发明公开
    1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof 失效
    1,1-二氧代青霉烷酰氧基甲基D-6-α（亚甲基氨基） - 苯基乙酰氨基 - 青霉烯和Verfahren zu seiner Herstellung

    公开(公告)号：EP0405316A2

    公开(公告)日：1991-01-02

    申请号：EP90111655.8

    申请日：1990-06-20

    申请人： Kim, Yeong Sul

    发明人： Kim, Yeong Sul

    IPC分类号： C07D499/68 ,  C07D499/32 ,  C07D499/86 ,  C07D519/00 ,  A61K31/43

    CPC分类号： C07D519/00

    摘要： A pharmaceutical compound which comprises reacting the sodium penicillanic acid 1,1-dioxides with chloroiodomethane in the presence of a solvent to produce chloromethylpenicillanate 1,1-dioxides, reacting the chloromethylpenicillanate 1,1-dioxides with a sodium iodide to produce iodomethylpenicillanate 1,1-dioxides, and reacting the iodomethylpenicillanate 1,1-dioxide with sodium methampicillin and is effective in the treatment of bacterial infections in a mammal.

    摘要翻译： 一种药物化合物，其包括在溶剂存在下使青霉烷酸1,1-二氧化物钠与氯碘代甲烷反应，生产氯甲基青霉素1,1-二氧化物，使氯代甲基青霉素1,1-二氧化物与碘化钠反应，生成碘甲基青霉素1,1 并且使碘甲基青霉素1,1-二氧化物与甲基青霉素钠反应，并且在哺乳动物的细菌感染的治疗中是有效的。

    Optically active, ethylenically unsaturated monomers and polymers thereof
    38.
    发明公开
    Optically active, ethylenically unsaturated monomers and polymers thereof 失效
    Optisch aktive，ethylenischungesättigteMonomere und deren Polymere。

    公开(公告)号：EP0281234A1

    公开(公告)日：1988-09-07

    申请号：EP88300570.4

    申请日：1988-01-25

    申请人： M & D RESEARCH CO., LTD.

    发明人： Saotome, Yasushi ,  Miyazawa, Takeo ,  Endo, Takeshi

    IPC分类号： C07D499/32 ,  C07D499/46 ,  C08F20/60 ,  C08F12/26

    CPC分类号： C08F20/60 ,  C07D499/00 ,  C08F12/26

    摘要： Disclosed are an optically active, ethylenically unsaturated monomer represented by the following structural formula:
    wherein: A stands for S, SO or SO₂; X and Y each stand for a hydrogen atom or a substituent selected from the group consisting of alkyl groups and acyl groups; Z stands for a substituent selected from the group consisting of alkoxy, alkylamino, hydroxyl and silyloxy groups; and X and Y can be bonded together to form a ring with the nitrogen atom to which they are bonded or X and Y can be a single group bonded to said nitrogen atom through a double bond, with the proviso that at least one of X and Z is an alkenyl equivalent to said group,
    and polymers of this monomer. One typical instance of the monomer is benzyl 6-acrylaminopenicillanate.

    摘要翻译： 公开了由以下结构式表示的光学活性的烯属不饱和单体：其中：A代表S，SO或SO 2; X和Y各自代表氢原子或选自烷基和酰基的取代基; Z表示选自烷氧基，烷基氨基，羟基和甲硅烷氧基的取代基; 并且X和Y可以键合在一起形成与它们所键合的氮原子形成的环，或者X和Y可以是通过双键与所述氮原子键合的单基，条件是X和 Z是与所述基团相当的烯基，以及该单体的聚合物。 单体的一个典型实例是6-丙烯基氨基青霉烷酸苄酯。