利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

111 条记录 (耗时 0.014 秒)

    POLYACETYLEN COMPOUNDS ISOLATED FROM CUSSONIA
    32.
    发明公开
    POLYACETYLEN COMPOUNDS ISOLATED FROM CUSSONIA 审中-公开
    从苏珊菌分离的聚乙炔化合物

    公开(公告)号：EP1858505A2

    公开(公告)日：2007-11-28

    申请号：EP05825898.9

    申请日：2005-12-22

    申请人： University of Basel ,  University of Bern ,  Swiss Tropical Institute

    发明人： SIMMEN, Urs ,  SIGEL, Erwin ,  BRUN, Reto ,  SEQUIN, Urs ,  SENN, Martin

    IPC分类号： A61K31/22 ,  A61K36/25 ,  A61P25/22

    CPC分类号： A61K31/22 ,  A61K36/25

    摘要： The present invention relates to certain linear polyacetylene containing compounds which are indicated as having a positive allosteric modulating activity on the GABAA receptor. More specifically the invention relates to linear polyacetylene containing compounds having a β-subunit selective, positive allosteric modulating activity on the GABAA receptor and substantially lacking a binding capability at the benzodiazepine binding site, their use as agents for the treatment of diseases of the central nervous system (CNS) in mammals, such as humans, and in particular in the treatment of CNS diseases, such as anxiety and epilepsy.

    摘要翻译： 本发明涉及某些含有线性聚乙炔的化合物，其被表明对GABAA受体具有正变构调节活性。 更具体地说，本发明涉及含有线型聚乙炔的化合物，该化合物对GABAA受体具有β亚单位选择性，正变构调节活性并基本上不具有对苯二氮卓结合位点的结合能力，它们作为治疗中枢神经系统疾病的药物 系统（CNS）在哺乳动物如人类中的应用，特别是用于治疗CNS疾病，如焦虑和癫痫。

    COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASE, COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT
    35.
    发明公开
    COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASE, COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT 审中-公开

    公开(公告)号：EP4162942A1

    公开(公告)日：2023-04-12

    申请号：EP21817604.8

    申请日：2021-06-04

    申请人： Back, Ju Youn

    发明人： KIM, Soong Jin ,  ROH, Yu Yeon

    IPC分类号： A61K36/185 ,  A61K36/71 ,  A61K36/25 ,  A61K36/355 ,  A61K36/84 ,  A61K36/23 ,  A61K36/88 ,  A61K36/484 ,  A61K31/36 ,  A61K31/7048

    摘要： The present invention relates to a composition, for preventing or treating an inflammatory disease, comprising, as an active ingredient, a self-hydrolysis extract using a hydrolase in a plant cell from one or more plants selected from Pulsatilla koreana, Pulsatilla chinensis, Pulsatilla cernua, Anemone raddeana, Aralia elata, Akebia quinata, Lonicera species, Adonis amurensis, Hedera helix, Hedera colchica and Patrinia scabiosifolia, and/or additionally an angiogenesis inhibitor. The composition, for preventing or treating an inflammatory disease, comprising a hydrolysis extract of Pulsatilla koreana and Anemone raddeana and/or an angiogenesis inhibitor as an active ingredient is prepared by means of: i) a first step of preparing a first-plant self culture medium by adding distilled water to a first plant and grinding same; ii) a second step of preparing a second-plant extract by applying an organic solvent to a second plant; iii) a third step of mixing the first-plant self culture medium of the first step and the second-plant extract of the second step and hydrolyzing same while stirring at 37°C; iv) a fourth step of fractionating by applying an organic solvent to the hydrolysis product obtained by means of the hydrolysis of the third step; v) a fifth step of obtaining an eluate by applying the fraction of the fourth step to column chromatography; and vi) a sixth step of fractionating by applying an organic solvent to the eluate of the fifth step.

    METHOD FOR DELIPIDATING PLANT EXTRACTS
    38.
    发明公开
    METHOD FOR DELIPIDATING PLANT EXTRACTS 审中-公开

    公开(公告)号：EP3903799A1

    公开(公告)日：2021-11-03

    申请号：EP20172098.4

    申请日：2020-04-29

    申请人： Max Zeller Söhne AG

    发明人： BOONEN, Georg ,  KREUTER, Matthias-Heinrich ,  DISCH, Lucia

    IPC分类号： A61K36/25 ,  A61K36/38 ,  A61K36/63

    摘要： The present invention is directed to a method for preparing plant extracts comprising the steps of (i) preparing a soluble extract from (a) plants or parts thereof and (b) an aqueous, alcoholic or aqueous alcoholic mixed extractant; and removal of insoluble components, (ii) concentrating the extract to a dry substance content at which the contained lipids and lipoids form suspended and/or emulgated aggregates, (iii) separating the suspended and/or emulgated aggregates by microfiltration from the concentrated extract, and (iv) optionally removing the extractant. The invention further pertains to an extract and composition comprising said extract as prepared by this method.