摘要:
A method of generating a set of solutions to a route-planning problem includes iteratively applying a Probability Collective (PC) method, each iteration including sampling from a probability distribution defined over a set of decision variables relating to a route-planning problem and using an archive set of decision variables and a set of the sampled decision variables to update the probability distribution for use in a subsequent said PC method iteration. A set of solutions, each of the solutions including at least one said decision variable with an associated objective function result evaluated by the PC method iterations, is output (214).
摘要:
Disclosed is a method and system for analyzing patient hospitalization data to determine a Nosocomial Infection Marker (NIM), the method comprising receiving from a database hospitalization data associated with at least one patient, calculating from the hospitalization data the number of specimens with non-duplicate hospital isolates (SNDHI) markers, calculating from the hospitalization data antibiotic utilization criteria (AUC) markers, and determining the nosocomial infection marker (NIM) for each patient, based upon the calculated SNDHI and AUC markers.
摘要:
A method of generating a set of solutions to a route-planning problem includes iteratively applying a Probability Collective (PC) method, each iteration including sampling from a probability distribution defined over a set of decision variables relating to a route-planning problem and using an archive set of decision variables and a set of the sampled decision variables to update the probability distribution for use in a subsequent said PC method iteration. A set of solutions, each of the solutions including at least one said decision variable with an associated objective function result evaluated by the PC method iterations, is output (214).
摘要:
A method of diagnosing or monitoring a condition of interest in a subject includes comparing thermograms generated using differential scanning calorimetery. A signature thermogram contains a protein composition pattern for a sample obtained from the subject. The signature thermogram is compared to a standard thermogram. Standard thermograms can include a negative standard thermogram containing a protein composition pattern associated with an absence of the condition of interest, and a positive standard thermogram containing a protein composition pattern associated with a presence of the condition of interest.
摘要:
A novel method is disclosed for efficiently solving minimax problems, and in particular, for efficiently solving minimax problems wherein the corresponding matrix is large. In particular, the novel method solves minimax problems in O(n 2 T) operation count, where denotes the problem size and T is reversely proportional to the required duality gap as one skilled in the art will understand, Further disclosed herein is a method for solving linear programming (LP) problems by converting such problems into minimax problems, and then using the novel minimax solution method disclosed herein.
摘要:
The invention relates to methods and systems for predicting or estimating the melting temperature of duplex nucleic acids, particularly duplexes of oligonucleotides which may be used, for example, as primers or probes in PCR and/or hybridization assays. The invention also relates to methods and systems for designing and selecting oligonucleotide probes and primers having a predicted melting temperature which is optimized for such assays. To this end, algorithms and methods are provided for predicting the melting temperature of a nucleic acid having a predetermined sequence. These methods and algorithms estimate the melting temperature of a nucleic acid duplex under particular salt conditions. The methods and algorithms use novel formulas, having terms and coefficients that are functions of the particular nucleotide sequence, to estimate the effect of particular salt conditions on the melting temperature. As such, the methods and systems of the invention provide superior result compared to existing methods, which do not consider sequence dependent effects of changing salt conditions.
摘要:
A method is provided for evaluating drug compounds based on their binding properties to human serum albumin wherein structural information at particular albumin binding regions is entered into a computer database and assessed with regard to particular contacting binding residues located in accordance with the invention. The information obtained through the computer database is thus useful in assessing and predicting drug interactions at albumin binding sites. Further, protein fragments including one or more albumin binding sites are provided which can be used in methods of assessing and designing drugs.
摘要:
Quantified Boolean formula (QBF) techniques are used in determining QBF satisfiability. A QBF is broken into component parts that are analyzable by a satisfiability (SAT) solver. Each component is then independently, and perhaps in parallel, analyzed for satisfiability. If a component is unsatisfiable, then it is determined that the QBF is unsatisfiable, and the analysis is stopped. If a component is satisfiable, then an assignment corresponding to the satisfiable component is noted. If a component is satisfiable, then it is appended to another untested component to provide a combination component, and the satisfiability of the combination component is analyzed. Such appending and analysis is repeated until the QBF is completed and determined to be satisfiable or determined to be unsatisfiable.