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    HUMAN PLASMA KALLIKREIN INHIBITORS
    42.
    发明公开
    HUMAN PLASMA KALLIKREIN INHIBITORS 审中-公开
    MENSCHLICHE PLASMAKALLIKREINHEMMER

    公开(公告)号：EP3113772A1

    公开(公告)日：2017-01-11

    申请号：EP15759254.4

    申请日：2015-03-09

    申请人： Biocryst Pharmaceuticals, Inc.

    发明人： KOTIAN, Pravin, L. ,  BABU, Yarlagadda, S. ,  WU, Minwan ,  CHINTAREDDY, Venkat, R. ,  KUMAR, V., Satish ,  ZHANG, Weihe

    IPC分类号： A61K31/415

    摘要： as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

    摘要翻译： 公开了本文所述的式（I）化合物及其药学上可接受的盐。 这些化合物是血浆激肽释放酶的抑制剂。 还提供了包含至少一种本发明化合物的药物组合物和涉及使用本发明的化合物和组合物治疗和预防以不需要的血浆激肽释放酶活性为特征的疾病和病症的方法。

    USEFUL PHARMACEUTICAL SALTS OF 7-[(3R, 4R)-3-HYDROXY-4-HYDROXYMETHYL-PYRROLIDIN-1-YLMETHYL]-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONE
    47.
    发明公开
    USEFUL PHARMACEUTICAL SALTS OF 7-[(3R, 4R)-3-HYDROXY-4-HYDROXYMETHYL-PYRROLIDIN-1-YLMETHYL]-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONE 有权
    从7有用的药物的盐 - [（3R，4R）-3-羟基-4-羟甲基 - 吡咯烷-1-基甲基] -3,5-二氢 - 吡咯并[3,2-d]嘧啶-4- ON

    公开(公告)号：EP2411394A2

    公开(公告)日：2012-02-01

    申请号：EP10756789.3

    申请日：2010-03-24

    申请人： BIOCRYST PHARMACEUTICALS, INC.

    发明人： BARTLEY, Gary ,  CLEARY, Thomas ,  LANG, John, F.

    IPC分类号： C07D487/04 ,  C07D403/04

    CPC分类号： C07D487/04

    摘要： The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.