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41.发明公开
公开(公告)号：EP0453554A1
公开(公告)日：1991-10-30
申请号：EP91900088.0
申请日：1990-11-13
CPC分类号： C07K16/1072 , A61K38/00 , C07K16/1054 , C07K16/1063 , C07K16/462 , C07K2317/24 , C07K2319/00 , C07K2319/036
摘要： Sont décrits des immunoglobulines, des fragments ou des dérivés chimériques présentant toute ou partie d'une région constante d'immunoglobuline humaine et d'une région variable murine, ayant une spécificité à l'égard d'antigènes du virus-1 d'immudéficience humaine (VIH-1), leurs procédés de production et leurs emplois.
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42.发明公开Internal organ-preserving liquid and method for preserving internal organs 失效Aufbewahrungsflüssigkeitund Aufbewahrungsverfahrenfürinnere Organe。
公开(公告)号：EP0440925A1
公开(公告)日：1991-08-14
申请号：EP90123772.7
申请日：1990-12-11
发明人： Kuroda, Yoshikazu, c/o Kobe University , Saito, Yoichi, c/o Kobe University , Murashima, Ryoichiro, The Green Cross Corporation , Yamanouchi, Koichi, The Green Cross Corporation
IPC分类号： A01N1/02
CPC分类号： A01N1/0221 , A01N1/02
摘要： Organ-preserving liquids comprising, as an active ingredient, an undiluted liquid of a perfluorocarbon compound or an emulsion containing the same at a high concentration and methods for preserving internal organs are disclosed. The internal organ-preserving liquids of the present invention are extremely useful in the clinical situations as organ-preserving liquids in organ transplantation for mammals including humans, especially as preserving liquids for internal organs having likelihood of thermal ischemic disorders.
According to the present invention, internal organs (e.g. pancreas, liver) are preserved by immersing the internal organs in an undiluted liquid of a perfluorocarbon or an emulsion thereof at a high concentration, preferably, with oxygen bubbling.摘要翻译： 本发明公开了以高浓度含有全氟化碳化合物的未稀释液体或含有该全氟化碳化合物的乳液作为有效成分的器官保存液体，以及保存内脏的方法。 本发明的内部器官保存液体在临床情况下是非常有用的，作为包括人在内的哺乳动物器官移植器官保存液体，特别是作为具有热缺血障碍可能性的内部器官的保存液体。 根据本发明，通过将内部器官以高浓度浸入全氟化碳的未稀释液体或其乳液中，优选用氧气鼓泡来保存内脏（例如胰腺，肝脏）。
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公开(公告)号：EP0399842A3
公开(公告)日：1991-07-31
申请号：EP90305730.5
申请日：1990-05-25
发明人： Tsuda, Yoshio, c/o Chuo Kenkyusho , Murashima, Ryoichiro, c/o Chuo Kenkyusho , Yamanouchi, Kouichi, c/o Chuo Kenkyusho , Yokoyama, Kazumasa, c/o Chuo Kenkyusho
IPC分类号： A61K31/435 , A61K31/025 , A61K9/107
CPC分类号： A61K9/0026 , A61K31/47
摘要： An emulsified preparation containing a perfluorocarbon compound comprises 5-50% (w/v) of a perfluorocarbon compound represented by the formula:
(wherein R represents a lower perfluoroalkyl group), 1-5% (w/v) of a phospholipid, 0.01-0.1% (w/v) of a fatty acid or an ester or a salt thereof, 0.001-0.01% (w/v) of tocopherol, 0.011-1.1% (w/v) of a pH adjuster, and an adequate amount of an aqueous solvent. This emulsified preparation can be used as an oxygen-carrying infusion fluid or perfusion fluid for preserving organs.-
公开(公告)号：EP0196761B1
公开(公告)日：1991-07-10
申请号：EP86301196.1
申请日：1986-02-20
发明人： Hirao, Yutaka , Uriyu, Katuhiro , Uemura, Yahiro
IPC分类号： A61L2/04
CPC分类号： A61L2/0023 , A61K39/39591 , A61K2300/00
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公开(公告)号：EP0428141A2
公开(公告)日：1991-05-22
申请号：EP90121728.1
申请日：1990-11-13
发明人： Ishida, Yutaka, c/o The Green Cross Corporation , Murakami, Koji, c/o The Green Cross Corporation , Hayasuke, Naofumi, c/o The Green Cross Corporation , Nakagawa, Yukimitsu, c/o The Green Cross Corp. , Kawabe, Haruhide, c/o The Green Cross Corp.
CPC分类号： C07K14/765 , C12N15/81
摘要： An improved yeast promoter wherein HSA productivity is greatly increased by combining SUC2-UAS and GAP-DH promoter, and production method thereof are discussed.
摘要翻译： 通过组合SUC2-UAS和GAP-DH启动子，其中HSA生产力大大增加的改进的酵母启动子及其制备方法。
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46.发明公开Gene expression unit comprising the promoter and the terminator as well as the gene of alkaline protease 失效Aus启动子，终止子和碱基碱性蛋白酶bestehende Genexpressionseinheit。
公开(公告)号：EP0427385A1
公开(公告)日：1991-05-15
申请号：EP90309821.8
申请日：1990-09-07
发明人： Murakami, Kohji, c/o Chuo Kenkyusho , Ishida, Yutaka, c/o Chuo Kenkyusho , Masaki, Atsushi, c/o Chuo Kenkyusho , Kawabe, Haruhide, c/o Chuo Kenkyusho , Arimura, Hirofumi, c/o Chuo Kenkyusho , Tatsumi, Hiroki , Murakami, Seiji , Nakano, Eiichi , Motai, Hiroshi
摘要： A novel alkaline protease promoter and alkaline protease terminator which each effectively function in a host-vector system of molds can be obtained from yellow koji mold. A gene expression unit comprising the promoter and terminator is used to construct an expression vector capable of expressing an useful substance in molds such as Aspergillus oryzae , Aspergillus niger , Aspergillus awamori , Aspergillus sojae , etc.
摘要翻译： 一种新型的碱性蛋白酶启动子和碱性蛋白酶终止子，其可以在黄色曲霉菌中得到，其在模具的宿主 - 载体系统中都有效。 包括启动子和终止子的基因表达单元用于构建能够在霉菌中表达有用物质的表达载体，例如米曲霉，黑曲霉，泡盛曲霉，大曲霉等。
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公开(公告)号：EP0420007A1
公开(公告)日：1991-04-03
申请号：EP90117928.3
申请日：1990-09-18
发明人： Ohtani, Wataru, c/o The Green Cross Corporation , Sumi, Akinori, c/o The Green Cross Corporation , Ohmura, Takao, c/o The Green Cross Corporation , Uemura, Yahiro, c/o The Green Cross Corporation
CPC分类号： C07K14/765
摘要： A method of purifying human serum albumin which comprises subjecting human serum albumin-containing solution to heat treatment of about 50-70°C for 1-5 hours in the presence of acetyltryptophan and/or an organic carboxylic acid with 6-12 carbon atoms or a salt thereof.
摘要翻译： 一种纯化人血清白蛋白的方法，其包括在乙酰色氨酸和/或具有6-12个碳原子的有机羧酸存在下，使含有血清白蛋白的溶液在约50-70℃下热处理1-5小时，或 其盐。
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公开(公告)号：EP0416527A2
公开(公告)日：1991-03-13
申请号：EP90116948.2
申请日：1990-09-04
发明人： Matsuda, Hiroshi, c/o The Green Cross Corporation , Ueda, Yasuo, The Green Cross Corporation , Yamanouchi, Koichi, The Green Cross Corporation
IPC分类号： A61K9/127 , A61K31/557
CPC分类号： A61K9/1272 , A61K9/127 , A61K31/557
摘要： The prostaglandin-containing liposome preparations which are characterized in that positive-charged lipid(s) is (are) incorporated in lipid thin membrane therein are discussed, and according to the present invention, release of prostaglandins from liposomes can be suppressed.
摘要翻译： 讨论了含有前列腺素的脂质体制剂，其特征在于将正电荷的脂质掺入其中的脂质薄膜中，根据本发明，可以抑制前列腺素从脂质体的释放。
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49.发明公开Fused yeast for foreign protein expression, methods of producing said yeast and methods of producing foreign proteins 失效融合的酵母为外来蛋白，使得该酵母的方法和用于生产外源蛋白的方法的表达。
公开(公告)号：EP0409156A1
公开(公告)日：1991-01-23
申请号：EP90113645.7
申请日：1990-07-17
发明人： Okabayashi, Ken, c/o The Green Cross Corporation , Ohi, Hideyuki, c/o The Green Cross Corporation , Hirabayashi, Kazumoto, c/o The Green Cross Corp. , Miura, Masami, c/o The Green Cross Corporation , Shimizu, Miho, c/o The Green Cross Corporation , Kawabe, Haruhide, c/o The Green Cross Corporation
CPC分类号： C12N15/81 , C12N15/04 , C12N15/815
摘要： The fused yeasts possessing the capabilities of producing foreign proteins of both parent yeasts, comprising a first yeast capable of producing a foreign protein wherein a DNA sequence encoding the foreign protein has been incorporated in the chromosome thereof, and a second yeast capable of producing a foreign protein wherein a DNA sequence encoding the foreign protein has been incorporated in the chromosome thereof, their production methods and methods of producing foreign proteins are disclosed. According to the present invention, noticeable improvement of foreign protein production can be expected.
摘要翻译： 将融合的酵母波塞唱歌同时产生亲本酵母菌外源蛋白，包括能产生外源蛋白质worin编码外源蛋白的DNA序列已被整合到染色体上的第一酵母和能够产生外国的第二酵母的能力 蛋白worin编码外源蛋白的DNA序列已整合到染色体上，它们的生产方法和生产外来蛋白质的方法是游离缺失盘。 。根据本发明，外源蛋白生产的显着改善可以预期的。
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50.发明公开
公开(公告)号：EP0408029A1
公开(公告)日：1991-01-16
申请号：EP90113335.5
申请日：1990-07-12
发明人： Uemura, Yahiro, c/o The Green Cross Corporation , Takechi, Kazuo, c/o The Green Cross Corporation , Tanaka, Kenji, c/o The Green Cross Corporation
CPC分类号： C07K1/22
摘要： A method of fractionating plasma protein which comprises treating a plasma protein-containing material in the following sequence of steps, provided that steps (ii) through (v) may be performed in an optional order:
(i) Freeze-thaw treatment
(ii) Treatment at 5 to 10% ethanol concentration
(iii) Treatment with an anion exchanger
(iv) Affinity chromatography with immobilized lysine
(v) Affinity chromatography with immobilized heparin
(vi) Treatment at 18 to 30% ethanol concentration
(vii) Treatment at 35 to 45% ethanol concentration摘要翻译： 一种分级血浆蛋白的方法，其包括按照以下顺序的步骤处理含血浆蛋白的材料，条件是步骤（ii）至（v）可以任选顺序进行：（i）冷冻 - 融化处理（ii） 以5至10％乙醇浓度处理（iii）用阴离子交换剂处理（iv）用固定化赖氨酸进行亲和层析（v）用固定化肝素进行亲和层析（vi）18至30％乙醇浓度处理（vii） 45％乙醇浓度r
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