公开(公告)号：EP1315485A1

公开(公告)日：2003-06-04

申请号：EP01961333.0

申请日：2001-09-04

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/35 ,  A61K31/335

CPC分类号： C07C405/00 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/4741 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07D221/04 ,  C07D335/04 ,  Y10S514/892 ,  A61K2300/00

摘要： An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1 : 1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache.

公开(公告)号：EP0668076B1

公开(公告)日：2002-09-04

申请号：EP94301108.0

申请日：1994-02-16

申请人： Sucampo AG

发明人： Ueno, Ryuji ,  Hirata, Ryu

IPC分类号： A61K31/557

CPC分类号： A61K31/5575

公开(公告)号：EP1420794B1

公开(公告)日：2017-12-27

申请号：EP02767866.3

申请日：2002-08-29

申请人： Sucampo AG

发明人： UENO, Ryuji ,  CUPPOLETTI, John

IPC分类号： A61K31/557 ,  C07C405/00

CPC分类号： C07C405/00 ,  A61K31/557

公开(公告)号：EP3035925A1

公开(公告)日：2016-06-29

申请号：EP14838126.2

申请日：2014-08-21

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/19 ,  A61P25/02 ,  A61P25/04

CPC分类号： C07C57/26 ,  A61K31/352 ,  C07C53/134

摘要： A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.

公开(公告)号：EP1984027B1

公开(公告)日：2015-12-30

申请号：EP07707565.3

申请日：2007-01-23

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K47/14 ,  A61K47/10 ,  A61K9/48 ,  A61K31/352 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08 ,  A61K47/36 ,  A61K31/353 ,  A61K31/382 ,  A61K31/4741

CPC分类号： A61K9/4858 ,  A61K9/08 ,  A61K31/352 ,  A61K31/353 ,  A61K31/382 ,  A61K31/4741 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36

公开(公告)号：EP2178516B1

公开(公告)日：2015-09-09

申请号：EP08778342.9

申请日：2008-07-16

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HARADA, Yasuhiro ,  KAWASAKI, Junichi ,  NISHIMURA, Yoshie ,  UENO, Ryuji

IPC分类号： A61K9/48 ,  A61K31/5575

CPC分类号： A61K47/14 ,  A61K9/4858 ,  A61K31/5575

摘要： Provided is a pharmaceutical composition comprising a 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.

公开(公告)号：EP2838525A1

公开(公告)日：2015-02-25

申请号：EP13777982.3

申请日：2013-04-19

申请人： Sucampo AG

发明人： UENO, Ryuji ,  LICHTLEN, Peter ,  GURNY, Robert ,  MOLLER, Michael

IPC分类号： A61K31/20 ,  A61K9/107 ,  A61K31/231 ,  A61K47/34

CPC分类号： A61K47/482 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/34

摘要： A fatty acid derivative-polymer conjugate including a conjugate comprising a fatty acid derivative and an alkyl substituted polylactide compound is provided. A pharmaceutical composition comprising the conjugate is also provided.

公开(公告)号：EP2175861B1

公开(公告)日：2014-08-20

申请号：EP08778018.5

申请日：2008-07-03

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K45/06 ,  A61K31/557 ,  A61K31/192 ,  A61K31/20 ,  A61P1/04 ,  A61P29/00 ,  A61P25/28 ,  A61P35/00

CPC分类号： A61K31/192 ,  A61K31/20 ,  A61K31/557 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2477632A1

公开(公告)日：2012-07-25

申请号：EP10817322.0

申请日：2010-09-16

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K31/513 ,  A61K45/00 ,  A61P35/00

CPC分类号： A61K31/558 ,  A61K31/352 ,  A61K31/5575 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed is a pharmaceutical combination comprising (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I):. The combination of the present invention is useful for the treatment of tumor in a mammalian subject. The instant application also provides a composition and a method for treating damages, especially gastrointestinal damages including mucositis induced by an anti-tumor agent comprising a fatty acid derivative of formula (I).

公开(公告)号：EP2435049A1

公开(公告)日：2012-04-04

申请号：EP10722792.8

申请日：2010-05-26

申请人： Sucampo AG ,  Osaka University

发明人： UENO, Ryuji ,  TSUKITA, Sachiko

IPC分类号： A61K31/5575 ,  A61K31/558 ,  A61P17/02

CPC分类号： A61K31/352 ,  A61K31/5575 ,  A61K31/558

摘要： Disclosed is a pharmaceutical composition for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.