摘要:
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
摘要:
The invention concerns a tank with means for detecting its condition by sending signals to an alarm device (25) emitting light signals, in which are provided means (50) for converting the light signals of the alarm device (25) into transformed signals capable of being recorded by a recording medium (53) arranged for recording the transformed signals derived from the converting means.
摘要:
A method for determining the number or concentration of virus particles in a sample by use of a light scattering detector. The method may be used to quantitate purified virus preparations or virus samples containing contaminants, including ultraviolet light-absorbing contaminants, such as proteins. The method is useful for quantitation of viruses for use in gene therapy, oncolytic viruses for tumor cell lysis and virus-based vaccines.
摘要:
A method for preparing surface-active agents, wherein the plant material is contacted with a hydrolysis agent selected from an acidic aqueous solution at 20-150 DEG C and an enzymatic composition for hydrolysing a plant material at 20-90 DEG C to give a sugar syrup, a solid marc is removed from the sugar syrup, the marc-free sugar syrup is contacted with an alcohol to give a solution of surface-active glycosides, and the mixture of surface-active glycosides is separated from said solution.
摘要:
Ce détendeur de gaz comprend un équipage mobile solidaire en déplacement d'un clapet et comprenant un siège conjugué d'une membrane (2,3) en définissant avec une ouverture (12) de celle-ci une soupape, le déplacement de la membrane (2,3) en direction de la première chambre (4) étant limité par des moyens (14) de limitation qui font partie de l'équipage mobile.
摘要:
A microinjection system (198) comprises a device (10) for housing dried forms of medical reagents, such as vaccines, hormones, etc. in single doses. Within a single chamber (14), a dry reagent bed (15) is provided adjacent a compression component (16) that keeps the bed (15) compacted. In operation, diluent (190) flows through the chamber (14) to carry the reagent out of the chamber (14) in fluid form. In the illustrated embodiments, the fluid (190) carrying reagent is directly delivered from the chamber via a needle (24). Integral or connectable diluent delivery devices (100) are disclosed for providing an appropriate volume of diluent (190) to the reagent chamber (14). Unstable formulations of drugs, for example, can be safely stored in dry form. When injection is needed, the drug can be delivered almost instantly in fluid form simply by releasing diluent through the chamber, where the reagent bed is dissolved or suspended while the remaining reagent is continually compacted. The resultant fluid (199) contains a single dose of the reagent and is delivered directly to a patient, desirably without measurement of the fluid form (199).
摘要:
The invention concerns a sealing top for a liquefied petroleum gas cylinder formed by a cap, comprising a top wall (1) extended by a skirt (2). A tubular portion (3), having a common axis (XX') with the cap (2), starts from the top wall (3) and flares downwards. A protuberance (4) is provided on the skirt (2) inner surface.
摘要:
Dans cette antenne en un élément en un matériau conducteur de l'électricité, l'élément comprend une toile (1) enrobée au moins en partie d'une nappe (2) de matière thermoplastique.
摘要:
Ce réservoir est constitué d'un profilé (1) en forme de C fermé par au moins un profilé intermédiaire en forme de U dont les branches (4, 5) sont convexes et par un second profilé (11) latéral en forme de C ouvert.