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41.发明公开
公开(公告)号：EP1881987A1
公开(公告)日：2008-01-30
申请号：EP06790516.6
申请日：2006-05-15
IPC分类号： C07D487/04 , A61K31/52
CPC分类号： C07D473/16 , C07D473/34
摘要： Compounds useful in the treatment of autoimmune disease are described by the following general formula (I): n = 0-2 m = 0-2 m is not necessarily equal to n; where R1, R3 = NH2, F, Cl, C1-C4 alkoxy or phenoxy group, but R1 is not necessarily equal to R3; and R2 = H, F, Cl, NH2, or NH- R- XH; where R = - (CH2)p - p = 2-4 = Formula (II), Formula (III) = Formula (IV) q = 0-3 X = CH2, NH, O, or S.
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42.发明公开
公开(公告)号：EP1877063A2
公开(公告)日：2008-01-16
申请号：EP06769970.2
申请日：2006-05-02
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula (1) are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups, and R1 and R2 have the definitions provided herein. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
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公开(公告)号：EP1535748B1
公开(公告)日：2008-01-09
申请号：EP03741134.5
申请日：2003-06-27
发明人： Natsui, Junpei, c/o Product Dev., Res. Lab. of , Tsuzuki, Yuji, c/o Product Dev., Res. Lab. of , Hamada, Kaoru, c/o Product Dev., Res. Lab. of , Date, Takashi, c/o Product Dev., Res. Lab. of
IPC分类号： B41M5/337
CPC分类号： B41M5/3375 , B41M5/3336 , B41M5/3372
摘要： Provided is a thermal recoding medium which exhibits high recording sensitivity, high heat resistance of non-image areas, and excellent storage stability of images. The recording medium contains in the thermal recording layer a sensitizer consisting of a compound represented by the general formula (1) and a stabilizer consisting of at least one member selected from among 3-{[(phenylamino)carbonyl]amino}benzenesulfonamide of the formula (2), the urea-urethane compound of the formula (3), and copolymers of glycidyl methacrylate and vinyl monomers (having average molecular weights of 9000 to 11000, epoxy equivalents of 300 to 600, and melting points of 110°C or below). Compounds represented by the general formula (4) are preferably used as the developer. (1) (2) (3) (4) [wherein R1 is hydrogen, halogeno, alkyl, or alkoxyl; and R2 is alkyl having 1 to 4 carbon atoms, alkoxyl, phenyl, or hydrogen.]
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公开(公告)号：EP1391198B1
公开(公告)日：2008-01-02
申请号：EP02722714.9
申请日：2002-04-19
IPC分类号： A61K31/165 , A61P43/00 , C07C233/18
CPC分类号： C07C233/18 , A61K31/165
摘要： A novel sphingolipid synthesis inhibitor comprising a compound represented by the general formula (A). Especially preferably, the novel sphingolipid synthesis inhibitor comprises a (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)alkanamide in which the alkanoyl group has 8 to 16 carbon atoms. (A) (In the formula, X is aliphatic alkyl, preferably C7-15 aliphatic alkyl.)
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45.发明公开USE OF CALCITONIN AND CALCITONIN-LIKE PEPTIDES TO TREAT AND PREVENT MULTIPLE SCLEROSIS 审中-公开降钙素和降钙素样肽用于治疗和预防多发性硬化症使用
公开(公告)号：EP1848455A1
公开(公告)日：2007-10-31
申请号：EP06734857.3
申请日：2006-02-13
IPC分类号： A61K38/23 , A61K31/593 , A61P25/00
CPC分类号： A61K31/593 , A61K38/23 , A61K2300/00
摘要： Methods for treating and preventing multiple sclerosis by administering to a patient an effective amount of calcitonin, calcitonin-like peptides or calcitonin mimetics to a patient. Additionally, 1,25-dihydroxyvitamin D analogs can be used in combination with the calcitonin, calcitonin-like peptides or calcitonin mimetics.
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46.发明公开2ALPHA-METHYL-19-NOR-1ALPHA-HYDROXY-HOMOPREGNACALCIFEROL AND ITS USES 审中-公开2ALPHA-METHYL-19-NOR-1ALPHA-HYDROXY-HOMOPREGNACALCIFEROL及其用途
公开(公告)号：EP1838667A2
公开(公告)日：2007-10-03
申请号：EP05851806.9
申请日：2005-11-18
发明人： DELUCA, Hector, F. , SICINSKI, Rafal, R. , PLUM, Lori, A. , CLAGETT-DAME, Margaret , GOWLUGARI, Sumithra
CPC分类号： C07C401/00
摘要： This invention discloses 2α-methyl-19-nor-vitamin D analogs, and specifically 2α-methyl-19-nor-1α-hydroxy-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译： 本发明公开了2α-甲基-19-去甲-D-维生素D类似物，特别是2α-甲基-19-去甲-1α-羟基 - 高炔丙醇缩水甾醇及其药物用途。 该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛， 皮肤干燥，皮脂分泌不足。 该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。 该化合物也可用于治疗或预防肥胖症。
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47.发明授权PORPHYRIN COMPOUNDS CONSISTING OF PORPHYRIN RINGS FUSED IN A SINGLE DIRECTION BY THREE BONDS, I.E., ONE MESO-MESO CARBON BOND AND TWO BETA-BETA CARBON BONDS AND PROCESS FOR THEIR SYNTHESIS 有权PORPPHYRINVERBINDUNGEN作者简明三个共价键的卟啉，四单一方向由 内消旋 - 中间相碳键和两个βBETA - 碳键及其制造方法
公开(公告)号：EP1318151B1
公开(公告)日：2007-10-03
申请号：EP01955602.6
申请日：2001-08-08
发明人： OSUKA, Atsuhiro
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： A porphyrin ring-fusion polymer which consists of two or more ZnII-porphyrin rings fused in a single direction and in which any two porphyrin rings adjacent to each other are fused by three covalent bonds, that is, one meso-meso carbon bond (i.e., one bond between meso-position carbon atoms) and two β-β carbon bonds (i.e., two bonds between β-position carbon atoms adjacent to the meso-position carbon atoms); a process for preparing the porphyrin ring-fusion polymer regioselectively by conducting the fusion reaction in an aromatic hydrocarbon solvent in the presence of a quinone and a Lewis acid containing a rare earth element under reflux; and fused-ring porphyrin compounds obtained by subjecting the prophyrin ring-fusion polymer to demetallization or replacement of the Zn atoms by other metal atoms.
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48.发明授权OXYSULFIDE PHOTOCATALYST FOR USE IN DECOMPOSITION OF WATER BY VISIBLE LIGHT 有权OXIDSULFIDPHOTOKATALYSATOR部分内使用的可见光恶化
公开(公告)号：EP1366811B1
公开(公告)日：2007-09-19
申请号：EP02711218.4
申请日：2002-01-23
CPC分类号： B01J35/004 , B01J23/63 , B01J27/04 , B01J27/045 , B01J35/002 , B01J37/0201 , B01J37/04 , C01B3/042 , C01B13/0207 , Y02E60/364
摘要： A photocatalyst which comprises an oxysulfide containing at least one transition metal; a preferable photocatalyst which also comprises a rare earth element such as Sm in addition to the above and wherein the transition metal is at least one selected from the group consisting of Ti and Nb; a more preferable photocatalyst which further comprises an auxiliary catalyst comprising a transition metal such as Pt carried on each of the above photocatalysts; and a catalyst for use in the decomposition of water by a light which comprises one of the above oxysulfide photocatalysts.
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49.发明公开Polyfunctional phenylene ether oligomer, derivative thereof, resin composition containing the same, and use thereof 审中-公开Polyfunktionelles Phenylen-Ether-Oligomer，Derivat davon，Harzzusammensetzung damit und deren Verwendung
公开(公告)号：EP1832617A2
公开(公告)日：2007-09-12
申请号：EP07250532.4
申请日：2007-02-09
发明人： Horino, Takeru, c/o Tokyo Work of , Ohno, Daisuke, c/o Tokyo Work of , Ishii, Kenji, c/o Tokyo Work of , Uera, Kazuyoshi, c/o Tokyo Work of
CPC分类号： C08G59/063 , C08G59/3218 , C08G65/44 , C08G65/485
摘要： A polyfunctional phenylene ether oligomer (B) having 3 to less than 9 phenolic hydroxyl groups, obtained by reacting a polyfunctional phenol (A) having 3 to less than 9 phenolic hydroxyl groups per molecule and having alkyl groups and/or alkylene groups at 2- and 6-positions of at least one of the phenolic hydroxyl groups with a monohydric phenol compound of the formula (1), derivatives thereof, resin compositions containing the derivatives, curable films obtained therefrom and cured films thereof,
wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a halogen atom, an alkyl group having 6 or less carbon atoms or a phenyl group, and R 3 and R 4 are the same or different and represent a halogen atom, an alkyl group having 6 or less carbon atoms or a phenyl group.摘要翻译： 通过使每分子具有3至小于9个酚羟基的多官能苯酚（A）与2-烷基和/或亚烷基反应，得到具有3至小于9个酚羟基的多官能亚苯基醚低聚物（B） 和至少一个酚羟基与式（1）的一元酚化合物的6-位，其衍生物，含有衍生物的树脂组合物，由其获得的固化膜及其固化膜，其中R 1和R 2是 相同或不同，表示氢原子，卤素原子，碳原子数6以下的烷基或苯基，R 3和R 4相同或不同，表示卤素原子，具有6个 或更少的碳原子或苯基。
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50.发明公开PROCESS FOR PRODUCING RARE EARTH ACTIVATED ALKALINE EARTH METAL FLUOROHALIDE PHOTOSTIMULABLE PHOSPHOR 审中-公开用于生产光激励磷光体物质基于甲SELTENERDMETALLAKTIVIERTEN ERDALKALIMETALLFLUORIDHALOGENIDS
公开(公告)号：EP1826259A1
公开(公告)日：2007-08-29
申请号：EP05806996.4
申请日：2005-11-15
发明人： WAKAMATSU, H., c/o Konica Minolta Tech. Ctr, Inc. , NABETA, H., c/o Konica Minolta Tech. Ctr, Inc.
CPC分类号： C09K11/7733
摘要： An objective is to provide a manufacturing process of a rare earth activated alkaline earth metal fluorohalide stimulable phosphor exhibiting improved productivity accompanied with an X-ray resistance property against repeating use upon X-ray exposure. Disclosed is a liquid phase manufacturing process of a rare earth activated alkaline earth metal fluorohalide stimulable phosphor represented in following Formula (1) possessing the steps of adding an aqueous solution containing inorganic fluoride into a reaction mother liquor in which barium halide is dissolved at a reaction temperature of 85 - 100 °C, to form a crystalline precipitate of a precursor of a rare earth activated alkaline earth metal fluorohalide stimulable phosphor, and removing a solvent from the reaction mother liquor, wherein a precursor of a stimulable phosphor is prepared via the foregoing steps conducted in parallel.
Formula (I) Ba (1-x) M 2 (x) FBr (y) I (1-y) : aM 1 , bLn, cO摘要翻译： 一个目的是提供一种稀土类激活的碱土金属fluorohalide刺激的磷表现出与伴随X射线resistanceproperty对重复后的X射线曝光使用提高生产率的制造过程。 公开的是在下述式（1）波塞唱向含有无机氟化物到其中卤化钡的反应母液wässrige溶液的步骤代表稀土金属激活的碱土金属fluorohalide刺激的磷的液相制造工序在反应溶解 的85-100℃的温度，以形成稀土金属激活的碱土金属fluorohalide刺激的磷的前体的结晶沉淀物，并从反应母液中除去溶剂，worin可激发磷的前体经由上述制备 在平行进行的步骤。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒFormula（I）€ƒ€ƒ€ƒ€ƒ€ƒBa（1-x）M 2（x）的FBR（Y）I（1-y）的： AM 1，BLn中，CO
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