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57 条记录 (耗时 0.032 秒)

    CONTRACEPTION SYSTEM AND METHOD
    46.
    发明授权
    CONTRACEPTION SYSTEM AND METHOD 失效
    方法和系统用于避孕

    公开(公告)号：EP0397823B1

    公开(公告)日：1999-01-07

    申请号：EP89912312.9

    申请日：1989-10-19

    申请人： BIO-TECHNOLOGY GENERAL CORPORATION

    发明人： Pasquale, Samuel A.

    IPC分类号： A61K31/565

    CPC分类号： A61K31/565 ,  A61K2300/00

    摘要： A method of contraception is disclosed which comprises a two-stage protocol. In the first stage, an estrogenic compound in a first composition is administered daily as the sole contraceptively active substance to a human female from about Day 2 to about Day 7 of her menstrual cycle, where Day 1 is the first day of menses. The second stage of the protocol occurs immediately thereafter during which at least one follow-up composition containing a progestin is administered daily to the same human female. The follow-up composition can contain a progestin as the sole contraceptively active ingredient, or can contain a combination of an estrogenic compound with a progestin in different weight ratios. A drug delivery system containing daily dosage units is also described.

    METHOD OF REMOVING N-TERMINAL AMINO ACID RESIDUES FROM EUCARYOTIC POLYPETIDE ANALOGS AND POLYPEPTIDES PRODUCED THEREBY
    48.
    发明授权
    METHOD OF REMOVING N-TERMINAL AMINO ACID RESIDUES FROM EUCARYOTIC POLYPETIDE ANALOGS AND POLYPEPTIDES PRODUCED THEREBY 失效
    从有机多糖类模拟物中除去N-末端氨基酸残基的方法及其生产的多肽

    公开(公告)号：EP0191827B1

    公开(公告)日：1992-10-21

    申请号：EP85904198.0

    申请日：1985-08-09

    申请人： BIO-TECHNOLOGY GENERAL CORPORATION

    发明人： BLUMBERG, Shmaryahu ,  BEN MEIR, Daniela

    IPC分类号： C12P21/00

    CPC分类号： C12P21/06 ,  C07K14/555 ,  C07K14/61 ,  C12N9/48

    摘要： A method of sequentially removing one or more N-terminal amino acid residues from an analog of a eucaryotic polypeptide synthesized in a foreign host, comprises contacting the eucaryotic polypeptide analog with aminopeptidase under suitable conditions permitting sequential removal of N-terminal amino acid residues, where the polypeptide analog contains amino acid residue or sequence of residues which blocks the action of an aminopeptidase located at a position other than the N-terminal end of the polypeptide analog. A specific embodiment of the invention concerns removing both an N-terminal methionine residue and its adjacent Leucine residue from a growth hormone analog produced in bacteria by contacting the growth hormone analog with Aeromonas aminopeptidase under suitable conditions permitting removal of the N-terminal methionine and Leucine residues. The invention also concerns eucaryotic polypeptide analogs produced in accordance with the methods of the invention.

    Method for producing human growth hormone
    49.
    发明公开
    Method for producing human growth hormone 失效
    生产人体生长激素的方法

    公开(公告)号：EP0489711A3

    公开(公告)日：1992-10-07

    申请号：EP92101249.8

    申请日：1985-08-09

    申请人： BIO-TECHNOLOGY GENERAL CORPORATION

    发明人： Blumberg, Shmaryahu ,  Ben Meir, Daniela

    IPC分类号： C12N15/18 ,  C12P21/06 ,  C12N15/20 ,  C12N15/23

    CPC分类号： C12P21/06 ,  C07K14/555 ,  C07K14/61 ,  C12N9/48

    摘要： The invention relates to a method of producing a human growth hormone having the amino acid sequence of naturally occurring human growth hormone which comprises
    a) producing in a microbial host a first polypeptide which is characterized by the presence of one or more additional amino acids at the N-terminus of the amino acid sequence of naturally occurring human growth hormone; b) contacting the first polypeptide so produced with an enzyme, preferably an aminopeptidase, so as to produce a second polypeptide having the amino acid sequence of naturally occurring human growth hormone; and c) recovering the second polypeptide so produced. A preferred microbial host is a bacterium, especially E. coli .