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公开(公告)号：EP1538157A2
公开(公告)日：2005-06-08
申请号：EP04027175.1
申请日：1997-02-14
发明人： Fowlkes, Dana M. , Sparks, Andrew B. , Kay, Brian K. , Thorn, Judith M. , Quilliam, Lawrence M. , Der, Channing J. , Rider, James E.
IPC分类号： C07K5/04 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/705 , G01N33/53 , G01N33/567
CPC分类号： C07K7/06 , A61K38/00 , A61K47/62 , C07K7/08 , C07K14/001 , C07K14/435 , C07K2319/00 , C40B30/04 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/573 , G01N33/68 , G01N33/6845
摘要： Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been isolated from phage-displayed random peptide libraries which had been screened for isolates that bind to bacterial fusion proteins comprising SH3 and glutathione S-transferase (GST). Preferred peptides are disclosed which comprise a core 7-mer sequence (preferably, a consensus motif) and two or more, preferably at least six, additional amino acid residues flanking the core sequence, for a total length of 9, preferably at least 13, amino acid residues and no more than about 45 amino acid residues. Such peptides manifest preferential binding affinities for certain SH3 domains. The preferred peptides exhibit specific binding affinities for the Src-family of proteins. In vitro and in vivo results are presented which demonstrate the biochemical activity of such peptides.
摘要翻译： 对本发明公开了对蛋白质的Src同源区3（SH3）结构域具有普遍和特异性结合亲和力的肽。 具体而言，SH3结合肽已从噬菌体展示的随机肽文库中分离出来，筛选出的分离株与包含SH3和谷胱甘肽S-转移酶（GST）的细菌融合蛋白结合。 公开了优选的肽，其包含核心序列（优选地，共有基序）和两个或更多个，优选至少6个侧接核心序列的额外氨基酸残基，总长度为9个，优选至少13个， 氨基酸残基和不超过约45个氨基酸残基。 这样的肽表现出对某些SH3结构域的优先结合亲和力。 优选的肽对Src家族蛋白质表现出特异性结合亲和力。 呈现体外和体内结果，其证明了这些肽的生物化学活性。
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42.发明公开METHODS FOR USE OF NOVEL LYOPROTECTANTS AND INSTANT KIT FORMULATIONS FOR RADIOPHARMACEUTICALS USING THE SAME 失效利用新的保护产品的冷冻干燥和即时KIT其制剂用于放射性药物的方法
公开(公告)号：EP0793510A1
公开(公告)日：1997-09-10
申请号：EP95939110.0
申请日：1995-11-06
申请人： CYTOGEN CORPORATION
CPC分类号： A61K51/1051 , A61K39/39591 , A61K51/1072 , A61K51/1241
摘要： This invention relates to lyoprotection agents for protecting macromolecules during lyophilization or freeze-drying. In particular, methods for use of these lyoprotectants in conjugate formulations are disclosed. Additionally, this invention describes lyophilized instant kit formulations for the radiolabeling of pharmaceuticals and/or macromolecules.
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公开(公告)号：EP0789783A1
公开(公告)日：1997-08-20
申请号：EP95935014.0
申请日：1995-09-20
申请人： CYTOGEN CORPORATION
发明人： ALVAREZ, Vernon L.
IPC分类号： G01N33 , A61K38 , A61K49 , A61K51 , A61P35 , C07K1 , C07K7 , C07K14 , C12N15 , C12Q1 , C40B30 , C40B40
CPC分类号： C40B30/04 , A61K38/00 , C07K1/047 , C07K14/001 , C07K14/4727 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6845 , G01N33/6854
摘要： Abtides are provided. Abtides are peptides identified by a two-step process of screening random peptide libraries. In the first step, the target ligand is an antibody or receptor (or derivative thereof). The peptides identified in the first screening step are used as target ligands in the second screening step. The peptides identified in the second screening step are abtides. Abtides possess binding specificities that are similar to the binding specificities of the antibodies or receptors that are used in the first screening step. Abtides may be used in place of antibodies in many assays or therapeutic applications. Abtides binding to polymorphic epithelial mucin (PEM) are provided. Also provided are methods of obtaining abtides as well as diagnostic and therapeutic compounds containing abtides.
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公开(公告)号：EP0635001A1
公开(公告)日：1995-01-25
申请号：EP93911594.0
申请日：1993-04-08
申请人： CYTOGEN CORPORATION
CPC分类号： C07D207/452 , A61K47/50 , A61K51/082 , A61K51/088 , A61K51/1093 , A61K2121/00 , A61K2123/00 , C07C335/22 , C07C337/06 , C07D213/71
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公开(公告)号：EP0348261B1
公开(公告)日：1993-12-15
申请号：EP89401557.7
申请日：1989-06-06
申请人： CYTOGEN CORPORATION
IPC分类号： C07C243/00 , C07C215/00 , C07C217/00 , C07B59/00 , A61K49/02 , A61K43/00 , C07K15/00
CPC分类号： A61K51/1051 , A61K51/1063 , A61K2121/00
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公开(公告)号：EP0527954A4
公开(公告)日：1993-09-01
申请号：EP91911988
申请日：1991-05-07
申请人： CYTOGEN CORPORATION
IPC分类号： A61K47/48 , A61K51/08 , C07K1/00 , C07K14/825 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12Q1/02 , G01N33/50 , G01N33/68 , C07H21/00 , A61K35/14 , A61K37/00
CPC分类号： C07K1/00 , A61K47/62 , A61K51/082 , A61K51/088 , A61K2123/00 , C07K14/825 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/461 , C07K19/00 , C07K2319/00 , C07K2319/33 , C12Q1/02 , G01N33/5052 , G01N33/6854
摘要： A system or method for identifying and/or designing novel peptides and polypeptides comprising an amino acid sequence which mimics the molecular recognition site of either (a) a macromolecule such as an immunoglobulin, an enzyme, a receptor protein, a lectin or other binding protein or (b) a small molecule or a small region of a large molecule which functions as a ligand and is recognized and binds specifically to a macromolecule is disclosed. Novel peptides and polypeptides as well as conjugates of the peptides and polypeptides are also disclosed. Applications for use of the peptides, polypeptides and conjugates in a wide range of fields such as biomedicine; biological control and pest regulation; agriculture; cosmetics; environmental control and waste management; chemistry; catalysis; nutrition and food industries; military uses; climate control, etc. are disclosed.
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公开(公告)号：EP0175617B1
公开(公告)日：1991-10-30
申请号：EP85401776.1
申请日：1985-09-13
申请人： CYTOGEN CORPORATION
发明人： Goers, John Walter , Lee, Chyi , Siegel, Richard Charles , McKearn, Thomas Joseph , King, Hurley Dalton , Coughlin, Daniel James , Rodwell, John Dennis , Alvarez, Vernon Leon
IPC分类号： A61K39/395
CPC分类号： A61K51/1093 , A61K41/0042 , A61K41/0057 , A61K41/0071 , A61K51/10 , A61K2121/00
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48.发明授权Carbohydrate perturbations of viruses or viral antigens and utilization for diagnostic, prophylactic and/or therapeutic applications 失效乙型肝炎病毒感染或病毒抗原以及诊断，预防和/或治疗应用的应用
公开(公告)号：EP0229546B1
公开(公告)日：1991-09-11
申请号：EP86402610.9
申请日：1986-11-25
IPC分类号： G01N33/569 , A61K39/42
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/08 , C07K16/12 , C07K16/18 , C12N2710/16722 , Y02A50/386
摘要： Methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physicial structure of a carbohydrate residue that is naturally present : (2) that removes, wholly or in part, a carbohydrate residue ; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosacchardie "perturbation" are also described.
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49.发明公开Method for preparation of protein-chelator-metal ion compositions suitable for injection 失效Verfahren zur Herstellung von Protein-Chelator-Metallion-Zubereitungen，geeignet zur Injektion。
公开(公告)号：EP0264333A2
公开(公告)日：1988-04-20
申请号：EP87402300.5
申请日：1987-10-15
申请人： CYTOGEN CORPORATION
IPC分类号： A61K49/00 , A61K33/00 , A61K47/00 , A61K37/14 , A61K39/395
CPC分类号： A61K49/16 , A61K47/6887 , A61K49/085 , A61K51/1093 , A61K2121/00 , A61K2123/00
摘要： This invention relates to an improved method for preparing protein-chelator-metal ion complex compositions suited for parenteral administration to human patients. Also described are the in vivo therapeutic and diagnostic applications for which the compositions prepared according to this method are advantageously used.
摘要翻译： 本发明涉及一种适用于肠胃外给予人类患者的蛋白质 - 螯合剂 - 金属离子络合物组合物的改进方法。 还描述了有利地使用根据该方法制备的组合物的体内治疗和诊断应用。
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公开(公告)号：EP0173629A1
公开(公告)日：1986-03-05
申请号：EP85401695.3
申请日：1985-08-29
申请人： CYTOGEN CORPORATION
发明人： Lee, Chyi , Rodwell, John Dennis , Goers, John Walter Frank , Siegel, Richard Charles , Alvarez, Vernon Leon , McKearn, Thomas Joseph
IPC分类号： G01N33/534 , G01N33/577 , A61K49/02 , A61K43/00 , A61K39/395
CPC分类号： A61K49/16 , A61K49/085 , A61K51/1093 , A61K2121/00 , A61K2123/00 , G01N33/532 , G01N33/534 , G01N33/577
摘要： This invention relates to antibody-metal ion complexes having a metal ion coordinately bound to a compatible chelator covalently bound to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody-metal ion complexes. Therapeutic and in vitro and in vivo diagnostic methods utilizing such antibody-metal ion complexes are described.
摘要翻译： 本发明涉及具有与与抗体或抗体片段共价结合的相容性螯合剂配位结合的金属离子的抗体 - 金属离子络合物。 还描述了制备抗体 - 金属离子络合物的中间体的方法。 描述了利用这种抗体 - 金属离子络合物的治疗和体外和体内诊断方法。
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