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公开(公告)号：EP3382040A3
公开(公告)日：2018-10-31
申请号：EP18159299.9
申请日：2014-12-01
IPC分类号： C40B30/04 , C40B40/00 , C12Q1/68 , C12Q1/689 , C12Q1/6883
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/158
摘要： The application is related to novel signature sequences for diagnosis of Mycobacterium tuberculosis in clinical samples with 100% specificity and a very high degree of sensitivity.
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公开(公告)号：EP3382040A2
公开(公告)日：2018-10-03
申请号：EP18159299.9
申请日：2014-12-01
IPC分类号： C12Q1/689 , C12Q1/6883
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/158
摘要： The application is related to novel signature sequences for diagnosis of Mycobacterium tuberculosis in clinical samples with 100% specificity and a very high degree of sensitivity.
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公开(公告)号：EP3094977B1
公开(公告)日：2018-08-22
申请号：EP15703230.1
申请日：2015-01-14
发明人： LEMKE, Edward , SCHULTZ, Carsten , PLASS, Tillmann , NIKIC, Ivana , HOFFMANN, Jan-Erik , VALLE ARAMBURU, Iker
IPC分类号： G01N33/58 , C07C271/22 , C07C271/34
CPC分类号： C07C271/22 , C07C271/34 , G01N33/533 , G01N33/582
摘要： The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile.
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公开(公告)号：EP3314013A1
公开(公告)日：2018-05-02
申请号：EP16732613.1
申请日：2016-06-27
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/502738 , B01L3/502761 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/141 , B01L2300/021 , B01L2400/0424 , B01L2400/0436 , B01L2400/0439 , B01L2400/0487 , B01L2400/06 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629
摘要： The present invention relates to the field of microfluidics and in particular to methods for co-localizing a particle comprising DNA and/or RNA with a known barcode oligonucleotide. Thereby, the transcriptome or DNA of a cell can be barcoded and correlated to a cell phenotype or examined for the effect of a drug on the cell. The invention also provides microfluidic devices and systems having properties which make them particularly suitable for use in the methods of the invention.
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公开(公告)号：EP3309260A1
公开(公告)日：2018-04-18
申请号：EP16194038.2
申请日：2016-10-14
摘要： The invention relates to archaeal pyrrolysyl tRNA synthetases lacking a nuclear localization signal and/or comprising a nuclear export signal. The invention also relates to polynucleotides encoding said pyrrolysyl tRNA synthetases, eukaryotic cells comprising said polynucleotide and tRNA acylated by the pyrrolysyl tRNA synthetase or a polynucleotide encoding such tRNA, methods utilizing said cells for preparing polypeptides comprising unnatural amino acid residues, and kits useful in said methods.
摘要翻译： 本发明涉及缺乏核定位信号和/或包含核输出信号的古细菌吡咯赖氨酰tRNA合成酶。 本发明还涉及编码所述吡咯赖氨酰tRNA合成酶的多核苷酸，包含所述多核苷酸和由吡咯赖氨酰tRNA合成酶酰化的tRNA或编码此类tRNA的多核苷酸的真核细胞，利用所述细胞制备包含非天然氨基酸残基的多肽的方法，以及可用于所述 方法。
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46.发明授权UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF 有权包含环庚三烯或反环庚烯基类似物的非天然氨基酸及其用途
公开(公告)号：EP2670767B1
公开(公告)日：2017-12-20
申请号：EP12702538.5
申请日：2012-02-03
CPC分类号： C07C271/22 , C07B2200/09 , C07C271/34 , C07C2601/18 , C07C2602/24 , C07C2602/42 , C07K1/13 , C07K2/00 , C12P21/00 , C12P21/02
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47.发明公开LICHTMIKROSKOP MIT EINEM PROBENTISCH FÜR DIE KRYO-MIKROSKOPIE 审中-公开LICHTMIKROSKOP MIT EINEM PROBENTISCHFÜRDIE KRYO-MIKROSKOPIE
公开(公告)号：EP3175279A1
公开(公告)日：2017-06-07
申请号：EP15738083.3
申请日：2015-07-15
摘要： In a light microscope (1) for cryomicroscopy comprising at least one objective (2) and a sample stage (3) having a cutout (7) for a coolable holder (8) for a sample carrier mount, wherein the cutout (7) is covered by a cover (6), the sample stage (3) is displaceable in two horizontal directions (4). The cover (6) lies on the sample stage (3) in a floating fashion and the objective (2) penetrates through a cutout (12) corresponding to the objective (2) in the cover (6). The method for cooling a holder (8) for a sample carrier mount in a light microscope (1) for cryomicroscopy by causing liquid nitrogen to flow through a cooling line (15) open at at least one end in the holder (8) is distinguished by the fact that the quantity of liquid nitrogen is dimensioned such that the entire nitrogen is present in gaseous form at the at least one open end (16) of the cooling line (15).
摘要翻译： 在包括至少一个物镜（2）和样品台（3）的用于低温显微镜的光学显微镜（1）中，样品台（3）具有用于样品架支架的可冷却保持器（8）的切口（7），其中切口（7） 由盖（6）覆盖，样品台（3）可沿两个水平方向（4）移位。 盖（6）以浮动的方式位于样品台（3）上，物镜（2）穿过对应于盖（6）中的物镜（2）的切口（12）。 区别用于通过使液氮流过在保持器（8）中的至少一端开口的冷却管线（15）来冷却用于低温显微镜的光学显微镜（1）中的样品载体安装座的保持器（8）的方法 通过这样的事实确定液氮的尺寸，使得整个氮在气体形式下在冷却管线（15）的至少一个开口端（16）处存在。
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48.发明公开PYRIDOPYRAZINE COMPOUNDS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA 审中-公开PYRIDOPYRAZINVERBINDUNGEN和它们在治疗，减轻或预防感冒
公开(公告)号：EP3166943A1
公开(公告)日：2017-05-17
申请号：EP15745406.7
申请日：2015-07-06
发明人： SCHULZ-GASCH, Tanja , WEIKERT, Robert , NEIDHART, Werner , BUSCHMANN, Helmut , SZOLAR, Oliver , WOLKERSTORFER, Andrea , HANDLER, Norbert , ROCH, Franz-Ferdinand , CUSACK, Stephen
IPC分类号： C07D471/04 , A61K31/4985 , A61P31/12
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameliorating or preventing influenza. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（V）中，任选地在药学上可接受的盐，溶剂合物，多晶型物，共药物，共结晶体，前药，互变异构体，外消旋体，对映异构体，或非对映体或混合物的形式存在的化合物，这是有用 在治疗，缓解或预防流感。 进一步，特定的组合疗法是游离缺失盘。
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公开(公告)号：EP3077411A1
公开(公告)日：2016-10-12
申请号：EP14806623.6
申请日：2014-12-03
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , European Molecular Biology Laboratory , Centre National de la Recherche Scientifique (CNRS) , Université d'Aix Marseille
发明人： SIEWEKE, Michael , POGENBERG, Vivian , WILMANNS, Matthias , CONSANI TEXTOR, Larissa , VANHILLE, Laurent
CPC分类号： C07K14/82 , A61K2035/124 , C07K16/32 , C07K2319/00 , C07K2319/73 , C07K2319/80 , G01N33/502
摘要： The present invention relates to MafB mutants and uses thereof for research, screening and therapeutic purposes. In particular, the present invention relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the glutaminic acid residue at position 269 has been deleted or substituted with a basic amino acid. The present invention also relates to a MafB mutant polypeptide comprising the sequence as set forth in SEQ ID NO: 1 or 2 or a function conservative variant thereof wherein the valine residue at position 277 has been deleted or substituted with a polar amino acid.
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50.发明公开
公开(公告)号：EP2954050A2
公开(公告)日：2015-12-16
申请号：EP14708951.0
申请日：2014-02-10
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2710/14121 , C12N2710/14151 , C12N2795/10021 , C12N2795/10041
摘要： The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade Ia viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade Ia genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade Ia genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.
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