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公开(公告)号：EP0440333A3
公开(公告)日：1992-06-17
申请号：EP91300083.2
申请日：1991-01-07
发明人： Cincotta, Anthony , Meier, Albert
CPC分类号： A61K31/496 , A61K31/00 , A61K31/13 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/2257 , A61K45/06 , G01N33/74 , Y10S514/866 , A61K2300/00
摘要： A process for the long term modification and regulation of lipid metabolism -- generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes) -- by administratlon (i.e., by feed or injection into the bloodstream) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases in body fat deposits result by treatment of an obese species on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can also be controlled in humans on a long term basis by treatment corresponding to that of the treatment for obesity. The short term daily injections reset hormonal timing in the neural centers of the brain to produce long term effects.
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42.发明公开INHIBITION OF EUCARYOTIC PATHOGENS AND NEOPLASMS AND STIMULATION OF FIBROBLASTS AND LYMPHOCYTES WITH LYTIC PEPTIDES 失效抑制病原体和神经细胞和刺激纤维细胞和淋巴细胞与淋巴细胞
公开(公告)号：EP0383770A4
公开(公告)日：1991-08-14
申请号：EP88906595
申请日：1988-07-06
发明人： JAYNES, JESSE, M. , ENRIGHT, FREDERICK, M. , WHITE, KENNETH, L. , JEFFERS, GALE LOUISIANA STATE UNIVERSITY
IPC分类号： C12N5/00 , A61K31/00 , A61K38/00 , A61K38/46 , A61P31/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07K14/00 , C07K14/435 , C12N1/06 , C12N15/85
CPC分类号： C12N1/06 , A01K2217/05 , A61K38/00 , C07K14/43563
摘要： Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin or sarcotoxin, or a synergistic combination of cecropins or sarcotoxin with lysozyme, in an amount effective to lyse or inhibit the cells. Target cells include eucaryotic microorganisms such as protozoa, e.g. T. cruzi and P. falciparum, mammalian lymphomas and leukemias, and cells infected with intracellular pathogens such as viruses, bacteria and protozoa. Also disclosed is a method for stimulating proliferation of lymphocytes and fibroblasts by contacting such cells with an effective amount of cecropin or sarcotoxin. The methods may be in vitro or in vivo.
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43.发明公开THERAPEUTIC ANTIMICROBIAL POLYPEPTIDES, THEIR USE AND METHODS FOR PREPARATION 失效医药抗微生物多肽，它们用于制备和使用过程。
公开(公告)号：EP0365598A1
公开(公告)日：1990-05-02
申请号：EP88906511.0
申请日：1988-07-06
CPC分类号： C12N1/06 , A01K2217/05 , A61K38/00 , C07K14/43563 , Y02A50/414
摘要： A novel class of antimicrobial agents for animal species including cecropins, attacins, lysozymes, phage derived polypeptides, such as those transcribed from gene 13 of phage 22, an S protein from lambda phage, and an E protein from phage PhiXl74, as well as, synthetically derived polypeptides of similar nature. The antimicrobial agents can be used to treat microbial infections and as components of medicinal compositions. The genes encoding for such antimicrobial agents can be used to transform animal cells, especially embryonic cells. The transformed animals including such antimicrobial cells are also included.
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44.发明公开
公开(公告)号：EP4226376A1
公开(公告)日：2023-08-16
申请号：EP21878725.7
申请日：2021-10-06
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公开(公告)号：EP4199774A1
公开(公告)日：2023-06-28
申请号：EP21859308.5
申请日：2021-08-19
申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , Tigeraire, Inc.
IPC分类号： A42B3/28
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公开(公告)号：EP4192494A1
公开(公告)日：2023-06-14
申请号：EP21853955.9
申请日：2021-08-06
申请人： La Jolla Institute for Immunology , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： BENEDICT, Christopher , KAMIL, Jeremy P. , SIDDIQUEY, Mohammed Nure Alam , SAPHIRE, Erica Ollmann , NORRIS, Michael
IPC分类号： A61K38/16 , C07K14/045 , G01N33/569
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公开(公告)号：EP4178569A1
公开(公告)日：2023-05-17
申请号：EP21837684.6
申请日：2021-07-12
申请人： Eleusis Therapeutics US, Inc. , Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： BRIDGES, Ryan, Steven , CLIFTON, J., Cannon , CLIFTON, John, Bryan , FAMILY, Neiloufar , MAILLET, Emeline, L. , RAZ, Shlomi , NICHOLS, David, E. , NICHOLS, Charles, D.
IPC分类号： A61K31/352 , A61K31/4045 , A61K31/675
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公开(公告)号：EP4072578A1
公开(公告)日：2022-10-19
申请号：EP20897800.7
申请日：2020-12-09
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公开(公告)号：EP4007772A1
公开(公告)日：2022-06-08
申请号：EP20848437.8
申请日：2020-07-28
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